中国组织工程研究

中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (27): 3957-3962.doi: 10.3969/j.issn.2095-4344.2016.27.001

• 骨及关节损伤动物模型 Animal models of bone and joint injuries •    下一篇

基于三维有限元建模方法分析维医沙疗对兔股骨力学性能的影响

李艳娜1，居来提•买提肉孜1，尼加提•外力1，黄少君1，迪丽娜•马合木提1，木合塔尔•克力木1，张  锐2   

  1. 1新疆大学机械工程学院，新疆维吾尔自治区乌鲁木齐市  830047
    2新疆医科大学第六附属医院影像中心CT室，新疆维吾尔自治区乌鲁木齐市  830054
  • 修回日期:2016-04-20 出版日期:2016-06-30 发布日期:2016-06-30
  • 通讯作者: 居来提?买提肉孜，硕士，副教授，新疆大学机械工程学院，新疆维吾尔自治区乌鲁木齐市 830047
  • 作者简介:李艳娜，女，1992年生，新疆维吾尔自治区精河县人，新疆大学在读硕士，主要从事沙疗研究。
  • 基金资助:

    国家自然科学基金资助项目(81160542)

Influence of sand therapy in Uyghur medicine on mechanical properties of rabbits’ femur based on three-dimensional finite element modeling

Li Yan-na1, Julaiti•Maitirouzi1, Nijiati•Waili1, Huang Shao-jun1, Dilina•Mahemuti1, Muhetaer•Kelimu1, Zhang Rui2   

  1. 1College of Mechanical Engineering, Xinjiang University, Urumqi 830047, Xinjiang Uygur Autonomous Region, China
    2CT Room, Image Center, the Sixth Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • Revised:2016-04-20 Online:2016-06-30 Published:2016-06-30
  • Contact: Julaiti?Maitirouzi, Master, Associate professor, College of Mechanical Engineering, Xinjiang University, Urumqi 830047, Xinjiang Uygur Autonomous Region, China
  • About author:Li Yan-na, Studying for master’s degree, College of Mechanical Engineering, Xinjiang University, Urumqi 830047, Xinjiang Uygur Autonomous Region, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81160542

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摘要：

文章快速阅读：

 

文题释义：
有限元法：是一种高效能、常用的数值计算方法。科学计算领域常常需要求解各类微分方程，而许多微分方程的解析解一般很难得到，使用有限元法将微分方程离散化后，可以编制程序，使用计算机辅助求解。
维医沙疗：新疆维吾尔医学埋沙治疗简称维医沙疗。是一种自然疗法，利用吐鲁番地区特定气候，强烈日光照射下，依靠沙体在灼热细沙的传热，将人体患病部位埋入热沙中，通过生物传热、改善血液循环、促进代谢，对风湿病有特殊的疗效。

 

摘要
背景：以现代设计方法与数值仿真为基础的研究方法来探究维医埋沙疗法的作用机制成为了可能。
目的：探究一种基于CT值的非均匀各向同性的骨生物有限元建模方法，并观察维医沙疗对兔股骨力学性能的影响。
方法：利用木瓜蛋白酶建立8只新西兰成年大白兔右后股骨的骨性关节炎模型，并将其分为沙疗组和对照组。沙疗组进行维医埋沙治疗后，利用CT扫描所有兔股骨模型，将断层影像数据导入MIMICS软件，生成股骨3D模型，对其进行体网格划分，并赋予材料属性，然后在Ansys中进行三点弯曲模拟并求解；同时，对所有兔股骨模型进行体外三点弯曲试验，得到相应的挠度与最大应力值。最后，将基于三维有限元建模方法所得的结果与实验所得的结果进行对比分析。
结果与结论：①利用兔股骨三维有限元模型进行三点弯曲模拟分析所得到的挠度、最大应力跟试验中所得到的数据都有较好的相关性。②结果说明有限元建模方法比较符合骨的结构与材料属性，可用于进行骨骼受力和变形分析。

 

关键词: 实验动物, 骨软骨损伤与修复动物模型, 有限元分析, 股骨, CT值, MIMICS, 沙疗, 国家自然科学基金

Abstract:

BACKGROUND: On the basis of modern design method and numerical simulation, studies can explore the action mechanisms of sand therapy in Uyghur medicine.
OBJECTIVE: To explore a kind of non-homogeneous and isotropic biological bone finite element modeling method based on CT value, and to study the influence of sand therapy in Uyghur medicine on the mechanical properties of rabbits’ femur.
METHODS: Eight adult New Zealand white rabbits were used to establish osteoarthritis models of right posterior femur with papain. These rabbits were divided into sand therapy group and control group. In the sand therapy group, after treatment with sand therapy in Uyghur medicine, rabbit femoral models were scanned with CT. The fault image data were imported into MIMICS software. 3D model of femur was generated. The meshing was done. The material properties were given. Three-point bending in the Ansys was simulated and solved. Simultaneously, the isolated three point bending tests were performed in all rabbit models. The corresponding deflection and the maximum stress values were obtained. Finally, the results obtained from the three-dimensional finite element modeling method were compared with the results obtained from the experiments.
RESULTS AND CONCLUSION: (1) The deflection and the maximum stress obtained by the three-point bending simulation analysis with the three-dimensional finite element model of the rabbits’ femur were well correlated with the data obtained from the experiments. (2) These results indicate that the finite element modeling method is consistent with the structural and material properties of bone, which can be used to analyze the stress and deformation of bones.

 

 中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

Key words: Finite Element Analysis, Femur, Osteoarthritis, Tissue Engineering

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