中国组织工程研究

中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (5): 652-656.doi: 10.3969/j.issn.2095-4344.2016.05.008

• 心脏及血管损伤动物模型 Animal models of heart and vascular damage • 上一篇    下一篇

盐负荷对自发性高血压模型大鼠胸主动脉应力松弛特性的影响

常笑语1，吕雪漫2，黄淑华3，郑晓秋2，袁 毅2   

  1. 1吉林大学白求恩医学部临床医学院医疗系，吉林省长春市 130026；2吉林大学中日联谊医院眼科，吉林省长春市 130033；3吉林省人民医院眼科，吉林省长春市 130026
  • 收稿日期:2015-11-08 出版日期:2016-01-29 发布日期:2016-01-29
  • 通讯作者: 袁毅，博士，主任医师，吉林大学中日联谊医院眼科，吉林省长春市 130033
  • 作者简介:常笑语，男，1992年生，吉林省长春市人，汉族。
  • 基金资助:
    吉林省科技发展计划资助项目(20110492)

Effect of salt loading on thoracic aortic stress relaxation properties of rat models of spontaneous hypertension

Chang Xiao-yu1, Lv Xue-man2, Huang Shu-hua3, Zheng Xiao-qiu2, Yuan Yi2   

  1. 1Medical Department, Clinical Medical College, Norman Bethune Health Science Center of Jilin University, Changchun 130026, Jilin Province, China; 2Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China; 3Department of Ophthalmology, Jilin Province People’s Hospital, Changchun 130026, Jilin Province, China
  • Received:2015-11-08 Online:2016-01-29 Published:2016-01-29
  • Contact: Yuan Yi, M.D., Chief physician, Department of Ophthalmology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China
  • About author:Chang Xiao-yu, Medical Department, Clinical Medical College, Norman Bethune Health Science Center of Jilin University, Changchun 130026, Jilin Province, China
  • Supported by:

    Science and Technology Development Program of Jilin Province of China, No. 20110492

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摘要：

文章快速阅读：

文题释义：
应力松弛的特点：在维持恒定变形的材料中，应力会随时间的增长而减小，这种现象为应力松弛，它可理解为一种广义的蠕变。测定应力松弛曲线是测定松弛模量的实验基础。高温下的紧固零件，其内部的弹性预紧应力随时间衰减，会造成密封泄漏或松脱事故。松弛过程也会引起超静定结构(见结构力学)中内力随时间重新分布。

自发性高血压模型大鼠：此模型大鼠除有高血压自发率为100%特点外，还有高血压性心血管病变。各种遗传性高血压大鼠中以自发性高血压模型大鼠应用最多，自发性高血压模型大鼠的血压升高是由多基因遗传决定的，与人类高血压病十分类似，是研究高血压病发病机制和筛选降压药物较为理想的动物模型。

 

背景：近年来正常人尸体和动物动脉血管的力学特性和黏弹性研究取得了一定的成果。
目的：定量分析正常饲养自发性高血压大鼠和盐负荷自发性高血压大鼠胸主动脉拉伸力学特性。
方法：取 20 只自发性高血压大鼠，随机分为实验组和对照组各10只，对实验组大鼠持续盐负荷干预16周，对照组大鼠引用普通自来水，正常饮食。实验第16 周，取两组大鼠胸主动脉各10个试样进行应力松弛实验。

结果与结论：实验组大鼠胸主动脉试样7 200 s应力下降量、7 200 s归一化应力松弛函数下降值均低于对照组(P < 0.05)。结果证实，自发性高血压大鼠和盐负荷自发性高血压大鼠胸主动脉应力松弛特性均发生了改变，其中盐负荷自发性高血压大鼠变化较显著。 

ORCID: 0000-0001-7110-2715(袁毅)

关键词: 动物实验, 心肺损伤与修复动物模型, 自发性高血压, 高血压, 大鼠, 盐负荷, 胸主动脉, 应力松弛, 黏弹性, 力学特性归一化分析, 应力松弛函数方程

Abstract:

BACKGROUND: In recent years, great progress has been achieved in the mechanical and viscoelastic properties of arterial blood vessels of normal human corpses and animals.
OBJECTIVE: To quantitatively analyze the tensile mechanical properties of thoracic aorta in normally fed spontaneously hypertensive rats and salt-loaded spontaneously hypertensive rats.
METHODS: Twenty spontaneously hypertensive rats were obtained and randomly divided into experimental and control groups (n=10/group). Rats in the experimental group were subjected to continuous salt loading intervention for 16 weeks. Rats in the control group were fed with normal diet and ordinary tap water. At the 16th week, 10 specimens of thoracic aorta of rats from these two groups were harvested to conduct stress relaxation experiments. 
RESULTS AND CONCLUSION: The decrease in stress at 7 200 seconds and the decrease in normalized stress relaxation function value at 7 200 seconds of thoracic aortic specimens of rats in experimental group were both lower than those in the control group (P < 0.05). These results confirm that the stress relaxation properties of thoracic aorta of normally fed and salt-loaded spontaneously hypertensive rats change, wherein the changes in salt-loaded spontaneously hypertensive rats are more obvious.