中国组织工程研究

中国组织工程研究 ›› 2015, Vol. 19 ›› Issue (52): 8418-8422.doi: 10.3969/j.issn.2095-4344.2015.52.010

• 组织工程口腔材料 tissue-engineered oral materials • 上一篇    下一篇

聚醚醚酮/牙源性双相生物陶瓷复合材料的制备及力学性能

冷卫东1，刘彩云1，黄 翠2，艾 俊1，石从郁1，余和东1   

  1. 1湖北医药学院附属医院(十堰市太和医院)口腔医学中心，湖北省十堰市 442000；2武汉大学口腔医院口腔修复科，湖北省武汉市 430079
  • 收稿日期:2015-10-30 出版日期:2015-12-17 发布日期:2015-12-17
  • 通讯作者: 余和东，硕士，医师，湖北医药学院附属太和医院口腔医学中心，湖北省十堰市 442000
  • 作者简介:冷卫东，男，1968年生，湖北省丹江口市人，汉族，2004年四川大学华西口腔医学院毕业，博士，主任医师，教授，硕士生导师，主要从事口腔颌面部肿瘤的发生机制、术后软硬组织缺损修复研究和生物陶瓷研究。
  • 基金资助:

    国家自然科学基金应急管理项目(51541202)：3-D打印双管道骨修复生物复合材料的构建及相关机理研究；湖北省卫生和计划生育委员会一般项目(2015MB289)：聚醚醚酮/牙源性双相生物陶瓷复合材料的应用基础研究

Preparation and mechanical properties of polyetheretherketone/odontogenic biphasic bioceramic composites

Leng Wei-dong1, Liu Cai-yun1, Huang Cui2, Ai Jun1, Shi Cong-yu1,Yu He-dong1   

  1. 1Oral Medical Center, Hospital Affiliated to Hubei University of Medicine (Taihe Hospital of Shiyan City), Shiyan 442000, Hubei Province, China; 2Department of Prosthodontics, Hospital of Stomatology, Wuhan University, Wuhan 430079, Hubei Province, China
  • Received:2015-10-30 Online:2015-12-17 Published:2015-12-17
  • Contact: Yu He-dong, Master, Physician, Department of Prosthodontics, Hospital of Stomatology, Wuhan University, Wuhan 430079, Hubei Province, China
  • About author:Leng Wei-dong, M.D., Chief physician, Professor, Master’s supervisor, Oral Medical Center, Hospital Affiliated to Hubei University of Medicine (Taihe Hospital of Shiyan City) , Shiyan 442000, Hubei Province, China
  • Supported by:

     the National Natural Science Foundation of China, No. 51541202; General Program of Health and Family Planning Commission of Hubei Province of China, No. 2015MB289

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被引次数

1

摘要：

背景：牙齿的物理性质和化学组成与人体骨组织极为相似，且无机成分所占比例较大，因此可以考虑将牙齿作为一个潜在的自体或同种异体骨缺损修复材料。
目的：制备聚醚醚酮/牙源性双相生物陶瓷复合材料，并测试其机械性能。
方法：收集临床上废弃的人离体牙，经初步煅烧去除有机成分，将其浸泡于磷酸氢二铵溶液24 h后再次煅烧，制备成以羟基磷灰石和β-磷酸三钙为主要成分的双相陶瓷，粉碎后过200目筛，采用有机泡沫浸渍法制备出聚醚醚酮/牙源性双相生物陶瓷，行物相分析、扫描电镜、元素分析、孔隙率、抗压强度、黏结强度检测。
结果与结论：聚醚醚酮/牙源性双相生物陶瓷为多孔网状结构，且孔间相互连通，孔径100-800 µm，孔隙率为73.65%，抗压强度为(165.260±11.703) N，黏结强度为(14.63±6.21) MPa，陶瓷中P元素含量占19.8%、Ca元素含量占40.5%，主要物相为β-磷酸三钙、羟基磷灰石。结果说明制备的聚醚醚酮/牙源性双相生物陶瓷具有良好的力学性能。
 

关键词: 生物材料, 口腔生物材料, 聚醚醚酮/牙源性双相生物陶瓷复合材料, 制备, 骨组织力学性能, 羟基磷灰石, β-磷酸三钙, 国家自然科学基金

Abstract:

BACKGROUND: The physical properties and chemical composition of teeth are very similar with human bone tissue, and there are a larger proportion of inorganic components. Therefore, tooth can be considered as a potential repair material for autologous or allogeneic bone defects.
OBJECTIVE: To prepare polyetheretherketone/odontogenic biphasic bioceramic composite, and to test its mechanical properties.
METHODS: The human in vitro teeth of clinical waste were collected. The organic components were removed after a preliminary calcination. Another calcination was conducted after soaking in diammonium phosphate solution for 24 hours to prepare the biphasic ceramics with the main components of hydroxyapatite and β-tricalcium phosphate. The biphasic ceramics were ground and sieved using 200-mesh sieve followed by impregnation in organic foam to prepare polyetheretherketone/odontogenic biphasic bioceramics. Phase analysis, scanning electron microscopy, elemental analysis, porosity, compressive strength and bond strength test were conducted.
RESULTS AND CONCLUSION: Polyetheretherketone/odontogenic biphasic bioceramics presented porous network structure and interconnected holes, with the aperture of 100-800 μm, porosity of 73.65%, compressive strength of (165.260±11.703) N, bond strength of (14.63±6.21) MPa. P element content accounted for 19.8%, and Ca element content accounted for 40.5%. The main phases were β- tricalcium phosphate and hydroxyapatite. These results demonstrate that polyetheretherketone/odontogenic biphasic bioceramics have good mechanical properties. 
 

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