中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (46): 8716-8720.doi: 10.3969/j.issn.2095-4344.2012.46.033

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

组织工程化软骨构建的研究进展

刘尚仑，董 睿，马 勇   

  1. 南京中医药大学，江苏省南京市 210029
  • 收稿日期:2012-02-24 修回日期:2012-03-25 出版日期:2012-11-11 发布日期:2012-11-11
  • 通讯作者: 马勇，博士，教授，博士研究生导师，研究方向为中西医结合治疗骨关节病的研究。 zhongyi-my@263.net,
  • 作者简介:刘尚仑★，男，1987年生，江苏省新沂市人，汉族，南京中医药大学在读硕士，主要从事骨关节方面的研究。 liushanglun1986@126.com

Research advances in construction of tissue-engineered cartilage

Liu Shang-lun, Dong Rui, Ma Yong   

  1. Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
  • Received:2012-02-24 Revised:2012-03-25 Online:2012-11-11 Published:2012-11-11
  • Contact: Ma Yong, Doctor, Professor, Doctoral supervisor, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China zhongyi-my@263.n
  • About author:Liu Shang-lun★, Studying for master’s degree, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China liushanglun1986@126.com

PDF

392

被引次数

6

摘要：

背景：组织工程学方法为关节软骨缺损的修复提供了新的治疗模式，具有广阔的应用前景。
目的：探究组织工程化软骨的构建方法、研究方向和应用前景。
方法：检索中国期刊全文数据库(CNKI:1991至2011年)和Web of Science(1991至2011年)数据库，检索词分别为“组织工程，软骨损伤，种子细胞，支架”和“Tissue Engineering，Cartilage Defects，Seed Cell，Scaffolds”，语言分别设为中文和英文。阅读文题和摘要进行筛选，选择具有原创性，论点论据可靠且分析全面，密切相关的文章，排除重复性研究以及质量较差文章。按纳入排除标准筛选后，共纳入30篇文章。
结果与结论：组织工程化软骨多以各种种子细胞与不同的支架材料进行复合，且在软骨缺损修复中体现了较好的应用价值，但应用于临床还有许多具体问题需要解决。

关键词: 组织工程, 软骨, 构建骨髓间充质干细胞, 支架

Abstract:

BACKGROUND: Tissue engineering method provides a new treatment for repair of articular cartilage defects, which has broad application prospects.
OBJECTIVE: To explore the methods, researches and application prospects of the tissue-engineered cartilage construction.
METHODS: A computer-based online search of China Journal Full-text Database and Web of Science was performed for articles and reviews in Chinese and English from 1991 to 2011. The key words were “tissue engineering, cartilage defects, seed cell, scaffolds” in Chinese and English. By Screening reading titles and abstracts, relevant literatures were included. Repetitive articles with poor quality were excluded. Finally, 30 articles were included.
RESULTS AND CONCLUSION: Tissue-engineered cartilage with a variety of seed cells loaded composite scaffolds has made a great progress and shown a good role in repair of cartilage defects, but there are some specific problems to be solved in clinic.

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