中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (46): 8721-8726.doi: 10.3969/j.issn.2095-4344.2012.46.034

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

脑损伤合并骨折可加速骨折愈合及异位骨化

刘冠华，张 柳，梁春雨   

  1. 河北联合大学附属医院骨科，河北省唐山市 063000
  • 收稿日期:2012-03-12 修回日期:2012-03-26 出版日期:2012-11-11 发布日期:2013-03-16
  • 通讯作者: 张柳，教授，博士生导师，河北联合大学附属医院骨科，河北省唐山市 063000 zhliu130@sohu.com
  • 作者简介:刘冠华★，男，1984年生，河北省唐山市人，汉族，河北联合大学在读硕士，主要从事骨折愈合方面的研究。 lllggghhh4@163.com

Brain injury with fracture can accelerate fracture healing and heterotopic ossification

Liu Guan-hua, Zhang Liu, Liang Chun-yu   

  1. Department of Orthopedics, Affiliated Hospital of Hebei Union University, Tangshan 063000, Hebei Province, China
  • Received:2012-03-12 Revised:2012-03-26 Online:2012-11-11 Published:2013-03-16
  • Contact: Zhang Liu, Professor, Doctoral supervisor, Department of Orthopedics, Affiliated Hospital of Hebei Union University, Tangshan 063000, Hebei Province, China zhliu130@sohu.com
  • About author:Liu Guan-hua★, Studying for master ‘s degree, Department of Orthopedics, Affiliated Hospital of Hebei Union University, Tangshan 063000, Hebei Province, China lllggghhh4@163.com

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744

被引次数

12

摘要：

背景：临床实践及实验研究中发现，脑损伤合并骨折时，骨折愈合明显加快，并出现肥大骨痂和异位骨化的现象。
目的：阐述近年脑损伤对骨折愈合影响的研究进展和探索方向。
方法：应用计算机检索1990年1月至2011年11 月PubMed 数据库、Springer Link 数据库及CNKI、Elsevier-Sdol 数据库有关脑损伤对骨折愈合影响、脑损伤与异位骨化关系方面的文献，英文检索词为“traumatic brain injury，fracture healing，heterotopic ossification”，中文检索词为“外伤性脑损伤，骨折愈合，异位骨化”。排除与课题研究内容无关及重复类文章，共保留32篇文献进一步分析。
结果与结论：脑损伤时由于血脑屏障遭受破坏，使其通透性增高，某些具有成骨作用的因子通过开放的血脑屏障进入到体循环中，从而使血清中此类因子表达水平显著升高，同时成骨性因子作用于骨折端，促进骨痂形成，加速骨折的愈合。由于成骨因子和成骨环境长期存在，则提高了异位骨化的发生率。

关键词: 骨折愈合, 脑损伤, 骨痂, 异位骨化, 血脑屏障

Abstract:

BACKGROUND: Clinical practices and experimental researches have found that brain injury with fracture can accelerate fracture healing. Besides, the hypertrophic callus and heterotopic ossification can be found.
OBJECTIVE: To describe the research progresses and exploration direction of the effect of brain trauma on fracture healing.
METHODS: PubMed, Springer Link, CNKI, Elsevier-Sdol databases were searched by computer for papers concerning the effect of brain injury on fracture healing as well as the relationship between brain injury and heterotopic ossification from 1990-01/2011-11. The key words for search were “traumatic brain injury, fracture healing, heterotopic ossification" in English and Chinese. Literatures of irrelevant and repetitive content were excluded, and 32 literatures were included for further study.
RESULTS AND CONCLUSION: The blood-brain barrier damage leads to the increase of permeability when brain injuries. Certain factors which have osteogenic action can enter the systemic circulation through an open blood-brain barrier, and therefore, the expression levels of these factors in serum are significantly increased; meanwhile, the role of osteogenic factors in the fracture can promote callus formation and accelerate fracture healing. These findings suggest that the incidence of heterotopic ossification can be increased due to the coexistence of osteogenic factors and environment for a long time.

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