中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (41): 7737-7741.doi: 10.3969/j.issn.2095-4344.2012.41.028

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

骨髓间充质干细胞在脑胶质瘤治疗中的应用前景

范存刚，张庆俊   

  1. 北京大学人民医院神经外科，北京市 100044
  • 收稿日期:2011-11-18 修回日期:2011-12-16 出版日期:2012-10-07 发布日期:2012-10-07
  • 通讯作者: 张庆俊，主任医师，教授，博士生导师，北京大学人民医院神经外科，北京市 100044 zhangqjhb@yahoo.com.cn
  • 作者简介:范存刚☆， 男，1978年生，天津市人，汉族，北京大学医学部在读博士，主治医师，主要从事干细胞移植治疗中枢神经系统疾病研究。 fancungang@yahoo.com.cn

Application prospect of bone marrow mesenchymal stem cells in the treatment of glioma

Fan Cun-gang, Zhang Qing-jun   

  1. Department of Neurosurgery, People’s Hospital of Peking University, Beijing 100044, China
  • Received:2011-11-18 Revised:2011-12-16 Online:2012-10-07 Published:2012-10-07
  • Contact: Zhang Qing-jun, Chief physician, Professor, Doctoral supervisor, Department of Neurosurgery, People’s Hospital of Peking University, Beijing 100044, China zhangqjhb@yahoo.com.cn
  • About author:Fan Cun-gang☆, Studying for doctorate, Attending physician, Department of Neurosurgery, People’s Hospital of Peking University, Beijing 100044, China fancungang@yahoo.com.cn

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摘要：

背景：骨髓间充质干细胞具有向胶质瘤趋向性迁移的能力和抗胶质瘤作用。
目的：在复习相关文献的基础上，探讨骨髓间充质干细胞在脑胶质瘤治疗中的应用前景。
方法：由第一作者对CNKI和PubMed数据库进行检索，英文关键词为“mesenchymal stem cells，bone marrow，glioma”，中文检索词为“间充质干细胞，骨髓，胶质瘤”。共检索到51篇相关文献，根据入选标准最终剩余29篇文章进行归纳总结。
结果与结论：骨髓间充质干细胞具有较强的向胶质瘤趋向性迁移的能力，还可抑制胶质瘤细胞增殖、诱导胶质瘤分化；携带特定自杀基因、免疫基因、肿瘤坏死因子和溶瘤病毒的骨髓间充质干细胞可发挥更强大的抗肿瘤作用。骨髓间充质干细胞可作为脑胶质瘤基因治疗的理想载体。

关键词: 骨髓, 间充质干细胞, 脑胶质瘤, 基因治疗, 趋化, 干细胞

Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) display extensive tropism for glioma and exert anti-tumor effect on glioma.
OBJECTIVE: To investigate the therapeutic prospects of BMSCs in the treatment of glioma on the basis of reviewing related articles.
METHODS: The first author retrieved CNKI database and PubMed database for concerning articles. The key words were “mesenchymal stem cells, bone marrow, glioma” in Chinese and English. A total of 51 articles were retrieved primarily by computer, and 29 articles were finally included for review according to inclusion criteria.
RESULTS AND CONCLUSION: BMSCs have a strong migratory capacity towards glioma. In addition, BMSCs can inhibit the proliferation of glioma and induce the glioma cells differentiation. Moreover, the BMSCs carrying suicide genes, immune genes, tumor necrosis factor and oncolytic virus can exert stronger antitumor effect on glioma. BMSCs may serve as a promising vector for gene-targeted glioma therapy.

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