中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (34): 6397-6402.doi: 10.3969/j.issn.2095-4344.2012.34.026

• 组织构建综述 tissue construction review • 上一篇    下一篇

骨基质载体材料的生物学特点及其临床应用

张立峰1，李琪佳2   

  1. 1唐山市第二医院急诊科，河北省唐山市 063000；
    2 河北联合大学实验中心，河北省唐山市 063000
  • 收稿日期:2012-03-02 修回日期:2012-04-22 出版日期:2012-08-19 发布日期:2012-08-19
  • 通讯作者: 李琪佳，教授，硕士生导师，河北联合大学实验中心，河北省唐山市 063000 qjl1222@ hotmail.com
  • 作者简介:张立峰★，男，1971年生，河北省唐山市人，2010年河北联合大学毕业，硕士，副主任医师，主要从事骨创伤修复骨组织工程研究。 ts-zlf@163.com

Biological characteristics and clinical application of bone matrix as a carrier material

Zhang Li-feng1, Li Qi-jia2   

  1. 1Department of Emergency, Tangshan Second Hospital, Tangshan 063000, Hebei Province, China;
    2Laboratory Center, Hebei United University, Tangshan 063000, Hebei Province, China
  • Received:2012-03-02 Revised:2012-04-22 Online:2012-08-19 Published:2012-08-19
  • Contact: Li Qi-jia, Professor, Master’s supervisor, Laboratory Center, Hebei United University, Tangshan 063000, Hebei Province, China qjl1222@hotmail.com
  • About author:Zhang Li-feng★, Master, Associate chief physician, Department of Emergency, Tangshan Second Hospital, Tangshan 063000, Hebei Province, China ts-zlf@163.com

PDF

419

被引次数

6

摘要：

背景：骨组织工程支架材料中的骨基质载体材料为骨缺损修复治疗提供了更为有效的方法。
目的：重点介绍天然衍生骨载体材料-冻干脱钙骨基质、脱蛋白骨基质、脱细胞骨基质在骨组织工程中的应用。
方法：以“骨组织工程、冻干脱钙骨基质、脱蛋白骨基质、脱细胞骨基质、骨缺损；bone tissue engineering,scaffold materials,demineralized bone matrix, deprotein bone matrix,acellular bone matrix，bone defect”为检索词，由第一作者检索1994/2010 PubMed、CNKI及万方数据库等与骨组织工程领域有关的权威性文献。
结果与结论：冻干脱钙骨基质、脱蛋白骨基质及脱细胞骨基质均具有良好的生物相容性、极低的抗原性、无细胞毒性，作为骨组织工程载体材料，保留了骨的天然属性，具有多孔隙结构，可降解性及良好骨传导作用，为骨缺损的治疗开辟了一条新途径。

关键词: 骨组织工程, 支架材料, 骨基质, 骨缺损修复, 载体材料, 文献检索

Abstract:

BACKGROUND: Scaffold materials are the core of bone tissue engineering, and bone matrix as a carrier material is one kind of the scaffold materials that provides more effective therapeusis for bone defects.
OBJECTIVE: To especially introduce the application of freeze-dried demineralized bone matrix，deprotein bone matrix and acellular bone matrix in bone tissue engineering.
METHODS: The first author retrieved literatures from PubMed, CNKI, Wanfang databases with the key words of “bone tissue engineering, scaffold materials, demineralized bone matrix, deprotein bone matrix, acellular bone matrix, bone defect” in English and Chinese, respectively. The authority literatures summarized in bone tissue engineering field and published from 1994 to 2010 were included.
RESULTS AND CONCLUSION: The results indicate that freeze-dried demineralized bone matrix, deprotein bone matrix and acellular bone matrix display good biocompatibility, low antigenicity, and have no cytotoxicity. As carrier materials for bone tissue engineering, they have natural attributes of bones, such as porosities and bone conduction, which develops a new approach in bone defects repair.

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