中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (32): 6063-6070.doi: 10.3969/j.issn.2095-4344.2012.32.033

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

干细胞移植治疗肝硬化

王 娟1，邵丽春1，郭 庆1，孔 欣1，陈 哲2，周 波2，杨晓凤3   

  1. 解放军第463医院，1消化内科， 3血液内科，辽宁省沈阳市110042；2深圳市北科细胞工程研究所，广东省深圳市 518057
  • 收稿日期:2012-02-03 修回日期:2012-07-19 出版日期:2012-08-05 发布日期:2012-08-05
  • 通讯作者: 杨晓凤，主任医师，硕士生导师，解放军第463医院血液内科，辽宁省沈阳市 110042 Yxf463@yahoo.com.cn
  • 作者简介:王娟，女，1957年生，黑龙江省兰西县人，汉族，1982年哈尔滨医科大学毕业，主任医师，主要从事慢性肝病细胞生物治疗的基础及临床研究工作。 w_chch@hotmail.com

Stem cell transplantation for treatment of liver cirrhosis

Wang Juan1, Shao Li-chun1, Guo Qing1, Kong Xin1, Chen Zhe2, Zhou Bo2, Yang Xiao-feng3   

  1. 1Department of Gastroenterology, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China;
    2Shenzhen Beike Cell Engineering Research Institute, Shenzhen 518057, Guangdong Province, China；
    3Department of Hematology, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China
  • Received:2012-02-03 Revised:2012-07-19 Online:2012-08-05 Published:2012-08-05
  • Contact: Yang Xiao-feng, Chief physician, Master’s supervisor, Department of Hematology, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China Yxf463@yahoo.com.cn
  • About author:Wang Juan, Chief physician, Department of Gastroenterology, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China w_chch@hotmail.com

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被引次数

1

摘要：

背景：干细胞是具有自我更新和分化能力的细胞，可分化为肝系细胞。研究表明，干细胞移植治疗肝硬化患者有显示良好疗效的一些报告。
目的：对脐血干细胞移植、骨髓干细胞移植、外周血干细胞移植治疗肝硬化的研究予以分析，为肝硬化治疗提供新的手段。
方法：CNKI数据库中2002/2011检索有关干细胞移植与肝硬化的治疗文献，检索词为“肝硬化(liver/hepatic cirrhosis)；失代偿性肝硬化(decompensated cirrhosis)；外周静脉(peripheral vein)；干细胞(stem cell)；移植(transplantation)；脐血干细胞(umbilical cord blood stem cell, UCBSC)；骨髓干细胞(bone marrow stem cell, BMSCS)；自体骨髓干细胞(autologous bone marrow stem cell)；外周血干细胞(peripheral blood stem cell)”，共检索文献130篇。
结果与结论：干细胞作为一类具有自我更新扩增和多向分化潜能的细胞，在一定的条件下可分化为多种功能细胞。目前临床上治疗肝硬化所使用的干细胞主要有3种：脐血干细胞、骨髓干细胞、外周血干细胞。干细胞移植治疗肝硬化的临床应用虽刚刚起步，但有取得良好疗效的多篇报告。多数患者接受治疗后临床症状好转，肝功能改善，并且此方法操作简单易行，价格低廉，避免了免疫排斥又不涉及伦理道德等问题，具有可创性前景。

关键词: 肝硬化, 失代偿性肝硬化, 外周静脉, 干细胞, 移植, 脐血干细胞, 骨髓干细胞, 自体骨髓干细胞, 外周血干细胞, 文献计量

Abstract:

BACKGROUND: Stem cell has self-renewal and differentiation capacity, and can differentiate into hepatic lineage cells. Studies have shown that stem cell transplantation have achieved good effect for the treatment of liver cirrhosis.
OBJECTIVE: To provide a new treatment for patients with liver cirrhosis according to umbilical cord blood stem cell transplantation, bone marrow stem cell transplantation, peripheral bloodstem cell transplantation for treatment of liver cirrhosis.
METHODS: A retrieval was performed for the literature of the stem cell transplantation for the treatment of liver cirrhosis, using key words liver/hepatic cirrhosis; decompensated cirrhosis, peripheral vein; stem cell; transplantation; umbilical cord blood stem cell; bone marrow stem cell; autologous bone marrow stem cell and peripheral blood stem cell between 2002-01 and 2011-12 in China National Knowledge Infrastructure (CNKI) database.
RESULTS AND CONCLUSION: Stem cells with self-renewing amplification and multi-differentiation potential can differentiate into a variety of functional cells under certain conditions. There were three kinds of stem cells in the treatment liver cirrhosis clinically at present, including umbilical cord blood stem cells, bone marrow stem cells, and peripheral blood stem cells. Although the clinical application of stem cell transplantation in the treatment of liver cirrhosis has just started, it has acquired good efficacy. The majority of patients receiving treatment showed improvement in clinical symptoms and liver function. The method is of simple, inexpensive, and can avoid immune rejection as well as without involving the ethical and other issues.

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