中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (29): 5345-5349.doi: 10.3969/j.issn.2095-4344.2012.30.024

• 组织工程骨及软骨材料 tissue-engineered bone and cartilage materials • 上一篇    下一篇

聚氨基酸/羟基磷灰石椎间融合器植入山羊颈椎

彭 磊，权正学，谭 超，欧云生，唐 可   

  1. 重庆医科大学附属第一医院骨科，重庆市 400016
  • 收稿日期:2012-03-20 修回日期:2012-04-18 出版日期:2012-07-15 发布日期:2012-07-15
  • 通讯作者: 权正学，主任医师，教授，重庆医科大学附属第一医院骨科，重庆市 400016 quanzx18@ 126.com
  • 作者简介:彭磊★，男，1984年生，河南省信阳市人，汉族，重庆医科大学在读硕士，主要从事脊柱外科研究。 penglei828@ 126.com

Intervertebral fusion cage made by poly-amino acid/hydroxyapatite composites in a goat cervical spine model

Peng Lei, Quan Zheng-xue, Tan Chao, Ou Yun-sheng, Tang Ke   

  1. Department of Orthopedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • Received:2012-03-20 Revised:2012-04-18 Online:2012-07-15 Published:2012-07-15
  • Contact: Quan Zheng-xue, Chief physician, Professor, Department of Orthopedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China quanzx18@126.com
  • About author:Peng Lei★, Studying for master’s degree, Department of Orthopedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China penglei828@ 126.com

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摘要：

背景：聚氨基酸/纳米羟基磷灰石复合材料已被研究证实具有良好的生物安全性。
目的：观察聚氨基酸/羟基磷灰石椎间融合器对山羊颈椎的融合效果。
方法：取成年雄性山羊，切除C3、4椎间盘，清除软骨终板，随机分成实验组与对照组，分别植入聚氨基酸/羟基磷灰石颈椎间融合器与自体髂骨。术后2，4，8，12周行X射线检查；术后4，12周行CT扫描和组织学检查。
结果与结论：术后2周，实验组平均椎间高度高于对照组(P < 0.05)，术后4~12周，两组平均椎间高度差异无显著性意义。术后4周，实验组融合度评分差于对照组(P < 0.05)，术后12周两组融合度评分差异无显著性意义。术后4，12周，两组均可观察到从成骨细胞集聚、胶原增生到新骨形成的过程。表明聚氨基酸/羟基磷灰石椎间融合器具有良好的初始稳定性和融合效果，是一种理想的椎间融合装置。

关键词: 聚氨基酸/羟基磷灰石, 山羊颈椎, 椎间融合器, 融合, 生物材料

Abstract:

BACKGROUND: Poly-amino acid/nano-hydroxyapatite composite material has been proved to have a good bio-security.
OBJECTIVE: To evaluate the fusion effect of poly-amino acid/nano-hydroxyapatite interbody cage in a goat cervical spine model.
METHODS: Sixteen adult male goats underwent C3-4 discectomy and intervertebral fusion with poly-amino acid/nano-hydroxyapatite interbody cage (experimental group, n=8) or autogenous iliac (control group, n=8). X-ray was taken at 2, 4, 8 and 12 weeks after surgery to measure the intervertebral height. CT scanning and histology examination were performed at 4 and 12 weeks after surgery.
RESULTS AND CONCLUSION: Referring to radiography and histomorphology findings, the goats with poly-amino acid/nano-hydroxyapatite cage or autograft all showed fine fusion at 12 weeks, without significant difference. The intervertebral fusion cage of poly-amino acid/nano-hydroxyapatite has good initial stability and fusion which may be an ideal interbody fusion appliance.

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