中国组织工程研究

中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (25): 4031-4036.doi: 10.3969/j.issn.2095-4344.1795

• 干细胞综述 stem cell review • 上一篇    下一篇

干细胞组织工程技术辅助下颌牵张成骨的研究与进展

韩志琪，蒋伟东，周  诺
  

  1. 广西医科大学附属口腔医院口腔颌面外科，广西壮族自治区南宁市  530021
  • 修回日期:2019-03-19 出版日期:2019-09-08 发布日期:2019-09-08
  • 通讯作者: 周诺，教授，博士生导师，广西医科大学附属口腔医院口腔颌面外科，广西壮族自治区南宁市 530021
  • 作者简介:韩志琪，男，1993年生，河南省汤阴县人，汉族，广西医科大学附属口腔医学院在读硕士，主要从事颌骨牵张成骨机制的研究。
  • 基金资助:

    国家自然科学基金项目(81670970)，项目负责人：周诺

Research progress in stem cell-based tissue engineering technology assisting mandibular distraction osteogenesis

Han Zhiqi, Jiang Weidong, Zhou Nuo
  

  1. Department of Oral and Maxillofacial Surgery, Stomatology Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
  • Revised:2019-03-19 Online:2019-09-08 Published:2019-09-08
  • Contact: Zhou Nuo, Professor, Doctoral supervisor, Department of Oral and Maxillofacial Surgery, Stomatology Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
  • About author:Han Zhiqi, Master candidate, Department of Oral and Maxillofacial Surgery, Stomatology Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81670970 (to ZN)

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摘要：

文章快速阅读：

文题释义：
下颌牵张成骨：是一种内源性骨组织工程技术，切开下颌骨后在截骨线两端安放牵张器，经过一定时间的间歇期，缓慢牵张截骨间隙，从而激发机体自身组织的再生，达到延长骨骼的目的。
组织工程技术：基于细胞生物学、材料学及生物工程学的原理在体外构建具有生物活性的组织类似物以代替、修复、改善或再生人体受损或病变的各种组织器官。大量实验数据证实了干细胞组织工程技术辅助下颌牵张成骨是辅助牵张区快速、高效成骨、成血管的手段。

 

摘要
背景：下颌牵张成骨在临床取得重大反响以来，大量学者致力于增强成骨、缩短疗程的研究，其中干细胞移植作为当前的热点备受关注。
目的：总结目前使用干细胞组织工程技术辅助下颌牵张成骨的进展与不足。
方法：遵循PRISMA指南，由第一作者以“牵张成骨，下颌骨，下颌，干细胞”为中文检索词，以“distraction osteogenesis，mandibular，mandible，stem cells”为英文检索词，对PubMed、WOS、CNKI、万方等数据库分别进行检索，对文献中的动物模型、干细胞种类及移植方式等进行统计并制表做简要介绍。
结果与结论：从目标文献中严格按照标准筛选出51篇文献进行分析、总结。文献中干细胞移植的时机、方式及种类等有着很大的差异。大量动物实验结果证实干细胞组织工程技术可以增强下颌牵张成骨中骨与血管的再生。探讨干细胞组织工程技术辅助下颌牵张成骨中干细胞的选择与应用，不仅能为将来的治疗提供思路，还能为接下来的临床试验打下基础。


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程
ORCID: 0000-0003-1442-5969(韩志琪)

关键词: 下颌牵张成骨, 组织工程, 干细胞, 骨再生, 血管再生, 干细胞移植, 国家自然科学基金

Abstract:

BACKGROUND: Since mandibular distraction osteogenesis has achieved significant repercussions in clinical practice, many scholars have been working on studies that enhancing osteogenesis and shortening the course of treatment. Among them, stem cell transplantation has attracted much attention as a hotspot.
OBJECTIVE: To summarize the current progress and deficiency of stem cell-based tissue engineering technology assisting mandibular distraction osteogenesis.
METHODS: Following the PRISMA guidelines, a computer-based search of PubMed, WOS, CNKI and WanFang databases was performed by the first author for relevant articles with the keywords of “distraction osteogenesis,mandibular, mandible, stem cells” in English and Chinese, respectively. Animal models, types of stem cells and routes of transplantation in the selected literature were extracted and counted up. The results were tabulated and introduced briefly. 
RESULTS AND CONCLUSION: Fifty-one articles were strictly selected as per the eligibility criteria, analyzed and summarized. In the selected literature, the timing, methods and types of stem cell transplantation vary greatly. The majority of animal experimental studies have confirmed that stem cell-based tissue engineering technology can enhance bone and blood vessel regeneration in mandibular distraction osteogenesis. Explorations on the selection and application of stem cells in mandibular distraction osteogenesis assisted by stem cell-based tissue engineering technology cannot only provide ideas for future treatment, but also lay the foundation for clinical trials.

Key words: mandibular distraction osteogenesis, tissue engineering, stem cells, bone regeneration, angiogenesis, stem cell transplantation, National Natural Science Foundation of China

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