中国组织工程研究

中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (10): 1580-1585.doi: 10.3969/j.issn.2095-4344.0719

• 生物材料综述 biomaterial review • 上一篇    下一篇

构建含有均一、稳定分散碳纳米管心肌组织工程支架的最新进展

陈  典，胡青林，周美玲，洪 鲜，孙小夕，席姣娅
  

  1. 华中科技大学同济医学院基础医学院生理学系，脑研究所，药物靶点研究与药效学评价湖北省重点实验室，湖北省武汉市  430030
  • 收稿日期:2017-11-06 出版日期:2018-04-08 发布日期:2018-04-08
  • 通讯作者: 席姣娅，副教授，华中科技大学同济医学院基础医学院生理学系，湖北省武汉市 430030
  • 作者简介:陈典，男，1995年生，湖北省武穴市人，汉族，华中科技大学同济医学院本科在读，主要从事组织工程、干细胞研究。
  • 基金资助:
    国家自然科学基金(31100828)；华中科技大学自主创新基金(2013TS145，2017KFYXJJ058)；华中科技大学创新创业训练项目(2016A165)；国家级大学生创新创业训练项目(HUST:201710487086)

Advances in the construction of a scaffold for cardiac tissue engineering containing homogeneous and stable carbon nanotubes

Chen Dian, Hu Qing-lin, Zhou Mei-ling, Hong Xian, Sun Xiao-xi, Xi Jiao-ya
  

  1. Hubei Provincial Key Laboratory of Drug Target Research and Pharmacodynamics Evaluation, Institute of Brain Research, Department of Physiology, Basic Medicine School of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
  • Received:2017-11-06 Online:2018-04-08 Published:2018-04-08
  • Contact: Xi Jiao-ya, Associate professor, Hubei Provincial Key Laboratory of Drug Target Research and Pharmacodynamics Evaluation, Institute of Brain Research, Department of Physiology, Basic Medicine School of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
  • About author:Chen Dian, Hubei Provincial Key Laboratory of Drug Target Research and Pharmacodynamics Evaluation, Institute of Brain Research, Department of Physiology, Basic Medicine School of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
  • Supported by:
     the National Natural Science Foundation of China, No. 31100828; Independent Innovation Project of Huazhong University of Science and Technology, No. 2013TS145, 2017KFYXJJ058; the Innovation and Entrepreneurship Training Program of Huazhong University of Science and Technology, No. 2016A165; the National Innovation and Entrepreneurship Training Program for Undergraduates, No. HUST:201710487086

PDF

143

摘要：

文章快速阅读：

 

文题释义：
碳纳米管：是石墨片层卷曲形成的无缝圆柱管，质量轻，六边形结构连接完美，径向尺寸为纳米量级，轴向尺寸为微米量级，为管子两端基本上都封口的具有特殊结构的一维量子材料，其纵横比可超过1 000。
碳纳米管的分类：分为单壁碳纳米管和多壁碳纳米管，单壁碳纳米管是由单片层的石墨烯卷曲形成的一个无缝圆柱状结构，直径大小范围为0.4-3 nm；多壁碳纳米管是由一系列同心嵌套的石墨烯片层组成，相毗邻的石墨烯片层之间存在有范德华力，径向尺寸可达10-20 nm，轴向尺寸则可达10-50 μm。
 
摘要
背景：如何有效地将碳纳米管均匀分散于支架之中，是构建理想碳纳米管化支架的关键环节之一，也是目前研究的热点之一。
目的：综述构建含均一稳定分布碳纳米管的心肌组织工程支架的方法学进展。
方法：由第一作者检索Web of Science Core Collection数据库、PubMed数据库2004年10月至2017年1月的相关文献，英文关键词为“carbon nanotubes, dispersion，cardiac tissue engineering”，检索文献类型为研究原著，通过标题、摘要内容及正文内容筛选文献进行综述。
结果与结论：高比表面积、高深宽比和表面高低不平会导致碳纳米管聚集成束，因此能否将碳纳米管在聚合物支架中均匀稳定地分散开来，是构建理想的碳纳米管/聚合物复合支架的关键之一。在心肌组织工程中，对碳纳米管表面进行化学操作(共价修饰)或物理操作(非共价修饰)，可显著改善其分布的均一性和稳定性，有助于制备含均一稳定分散碳纳米管的心肌组织工程支架，明显改善工程心肌的机械性能和电传导性能。

关键词: 生物支架, 单壁碳纳米管, 多壁碳纳米管, 分散, 共价修饰, 非共价修饰, 生物材料

Abstract:

BACKGROUND: How to efficiently and uniformly disperse carbon nanotubes (CNTs) into a tissue-engineered scaffold is crucial to construct an ideal CNTs-Polymer composite scaffold and it is also a hotspot of research in the tissue engineering.
OBJECTIVE: To review the advances in the methodology progress of constructing a scaffold for cardiac tissue engineering, which contains uniformly and stably dispersed CNTs.
METHODS: The Web of Science Core Collection and PubMed were searched by the first author for related papers about CNTs dispersion in the cardiac tissue engineering published from October 2004 to January 2017. The key words were “carbon nanotubes, dispersion, cardiac tissue engineering” in English. Original research papers were searched, which were screened through titles, abstracts and contents, and then reviewed.
RESULTS AND CONCLUSION: CNTs are easy to aggregate because of high surface area, high aspect ratio and rough surface. Thus, it is one of the key points to construct an ideal CNTs-Polymer composite scaffold that whether CNTs could be uniformly and stably dispersed in polymer scaffolds. In the cardiac tissue engineering, covalent or non-covalent surface modification of CNTs significantly enhances the uniformity and stability of CNTs in the polymer scaffolds, which is conducive to construct the uniformly and stably CNTs-dispersed scaffold for cardiac tissue engineering, leading to notable improvement in mechanical and electrical properties of engineered cardiac tissues.

Key words: Nanotubes, Carbon, Nanostructures, Tissue Engineering

中图分类号: