中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (16): 3009-3012.doi: 10.3969/j.issn.1673-8225.2012.16.035

• 生物材料综述 biomaterial review • 上一篇    下一篇

γ-聚谷氨酸及其衍生物在生物医学领域中的应用*★◆

疏秀林1，施庆珊1，黄小茉2，郑国爱2，欧阳友生1，陈仪本1   

  1. 1广东省微生物研究所，广东省菌种保藏与应用重点实验室，广东省微生物应用新技术公共实验室，广东省华南应用微生物重点实验室—省部共建国家重点实验室培育基地，广东省广州市  510070；2广东迪美生物技术有限公司，广东省广州市  510663
  • 收稿日期:2011-09-30 修回日期:2011-10-11 出版日期:2012-04-15 发布日期:2012-04-15
  • 通讯作者: 施庆珊，研究员，广东省微生物研究所，广东省菌种保藏与应用重点实验室，广东省微生物应用新技术公共实验室，广东省华南应用微生物重点实验室—省部共建国家重点实验室培育基地，广东省广州市 510070 jigan@gdim.cn
  • 作者简介:疏秀林★，女，1980年生，安徽省安庆市人，汉族，2005年西北农林科技大学植物保护专业毕业，硕士，助理研究员，主要从事应用微生物学方面的研发工作。xiulin5403@ 126.com
  • 基金资助:

    广东省科技计划项目(2009A010700005)。

Application of gamma-poly glutamic acid and its derivatives in biomedical field

Shu Xiu-lin1, Shi Qing-shan1, Huang Xiao-mo2, Zheng Guo-ai2, Ouyang You-sheng1, Chen Yi-ben1   

  1. 1Guangdong Institute of Microbiology, Key Laboratory of Microbial Culture Collection and Application of Guangdong Province, Public Laboratory of Microbial Application of New Technology of Guangdong Province, State Key Laboratory of Applied Microbiology in South China of Guangdong Province (Ministry-Guangdong Province Jointly Breeding Base), Guangzhou  510070, Guangdong Province, China;    2Guangdong Demay Biological Technology Co., Ltd., Guangzhou  510663, Guangdong Province, China
  • Received:2011-09-30 Revised:2011-10-11 Online:2012-04-15 Published:2012-04-15
  • Contact: Shi Qing-shan, Researcher, Guangdong Institute of Microbiology, Key Laboratory of Microbial Culture Collection and Application of Guangdong Province, Public Laboratory of Microbial Application of New Technology of Guangdong Province, State Key Laboratory of Applied Microbiology in South China of Guangdong Province (Ministry-Guangdong Province Jointly Breeding Base), Guangzhou 510070, Guangdong Province, China jigan@gdim.cn
  • About author:Shu Xiu-lin★, Master, Assistant researcher, Guangdong Institute of Microbiology, Key Laboratory of Microbial Culture Collection and Application of Guangdong Province, Public Laboratory of Microbial Application of New Technology of Guangdong Province, State Key Laboratory of Applied Microbiology in South China of Guangdong Province (Ministry-Guangdong Province Jointly Breeding Base), Guangzhou 510070, Guangdong Province, China xiulin5403@126.com
  • Supported by:

    Science and Technology Program of Guangdong Province, No. 2009A010700005*

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摘要：

背景：γ-聚谷氨酸是一种经由微生物杆菌发酵合成的高分子材料，具有水溶性、吸水、保湿、生物可分解性，无毒、安全等特性，可以与其他材料聚合形成新型复合材料，在生物医学上具有很大的应用前景。
目的：综述γ-聚谷氨酸作为药物载体、医学美容、创伤辅料以及骨质修复材料等方面的研究进展。
方法：应用计算机检索1998-01/2011-05 CNKI、中国标准全文数据库和Science Direct 数据库，在标题和摘要中以“γ-聚谷氨酸，生物材料，药物载体，生物敷料，化妆品”或“γ-Polyglutamic acid; drug carrier; wound dressing; hemostatant; artifical skin; Cosmetics; biological adhesive; surgical suture; bone tissue engineering”为检索词进行检索。初检得到206篇文献，最终选择26篇文章进行综述。
结果与结论：γ-聚谷氨酸及其衍生物作为药物载体，可以改善药物的水溶性、降低毒性、控制药物释放以及提高药物靶向性；在医学美容方面，γ-聚谷氨酸为极理想的长效型安全超级保湿剂；在创伤敷料方面，γ-聚谷氨酸有助于降低血小板在敷料表面的黏附，具有止血促凝作用，能够诱导多种细胞增殖分化，增强生物敷料的稳定性和吸收渗液能力；作为骨组织工程支架，γ-聚谷氨酸有利于骨细胞生长，具有良好的亲水性能和降解性能，是一种理想的软骨组织工程支架材料。
关键词：药物控释系统及其载体材料；γ-聚谷氨酸；生物敷料；医学美容；骨替代材料
缩略语注释：γ-PGA：γ-Polyglutamic acid，γ-聚谷氨酸；CPT：camptothecins，喜树碱
doi:10.3969/j.issn.1673-8225.2012.16.035

关键词: 药物控释系统及其载体材料, &gamma, -聚谷氨酸, 生物敷料, 医学美容, 骨替代材料

Abstract:

BACKGROUND: γ-poly glutamic acid (γ-PGA) is a type of polymer material through fermentation production of microbial bacteria. This polymer has the features of water-solubility, absorbency, moisture retention, biodegradable, no toxicity and safety. The γ-PGA has a wide application prospect in biomedical engineering through composition with other materials.  
OBJECTIVE: To summarize the applications of γ-PGA in drug carriers, wound dressing, cosmetic medicine, and bone tissue engineering.
METHODS: Databases of CNKI, VIP, and Science Direct were retrieved with key words of “γ-poly glutamic acid, drug carrier materials, wound dressing, cosmetic medicine, artificial bone substitute materials” by screening titles and abstracts to search papers published from January 1998 to May 2011. Papers underlying bio-medical were selected. Totally 206 literatures were obtained in initial search, 26 of them were chosen to summarize according to inclusion criteria.
RESULTS AND CONCLUSION: As drug carrier, γ-PGA and its derivatives can improve the water-solubility, reduce the toxicity, and control the release and increase the targeting of drugs. It is an excellent and safe hydrophilic humectant in cosmetic medicine. As wound dressing, the addition of γ-PGA into wound dressing materials leads to a reduction in platelet adhesion and activation to increase hemostatic effect, induce cellular proliferation and differentiation, and improve the stability and effusion absorption of wound dressing. As bone tissue engineering scaffolds, γ-PGA copolymer scaffolds can promote the growth and proliferation of the osteoblasts, exhibit excellent biodegradation and biocompatibility, and are potential in tissue engineering as temporary substitutes for articular cartilage regeneration.

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