中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (12): 2137-2140.doi: 10.3969/j.issn.1673-8225.2012.12.011

• 纳米生物材料 nanobiomaterials • 上一篇    下一篇

载顺铂超顺磁γ-Fe2O3纳米粒子的制备与表征*☆

邱嘉旋1, 2，雷水金3，何远桥4，毛宗福1   

  1. 1武汉大学公共卫生学院，湖北省武汉市  430071；  2南昌大学第四附属医院口腔科，江西省南昌市 330003；3南昌大学材料科学与工程学院，江西省南昌市 330031；   4南昌大学实验动物科学部，江西省南昌市 330006
  • 收稿日期:2011-08-13 修回日期:2011-09-15 出版日期:2012-03-18 发布日期:2012-03-18
  • 通讯作者: 毛宗福，教授，博士生导师，武汉大学公共卫生学院，湖北省武汉市 430071 zfmao@126.com
  • 作者简介:邱嘉旋☆，男，1963年生，江西省抚州市人，武汉大学在读博士，教授，主要从事口腔颌面肿瘤预防与治疗方面研究。 qiujiaxuan@ 163.com
  • 基金资助:

    江西省科技厅资助项目(2008BA04400)。

Preparation and characterization of cisplatin-loaded super paramagnetic gamma-Fe2O3 nanoparticles 

Qiu Jia-xuan1, 2, Lei Shui-jin3, He Yuan-qiao4, Mao Zong-fu1   

  1. 1Public Health Department of Wuhan University, Wuhan  430071, Hubei Province. China; 2Department of Stomatology, the Fourth Affiliated Hospital of NanchangUniversity, Nanchang  330003, Jiangxi Province, China; 3School of MaterialsScience and Engineering, Nanchang University, Nanchang  330031, Jiangxi Province, China; 4Department of Laboratory Animal Science, Nanchang Medical College, Nanchang  330006, Jiangxi Province, China
  • Received:2011-08-13 Revised:2011-09-15 Online:2012-03-18 Published:2012-03-18
  • Contact: author: Mao Zong-fu, Professor, Doctoral supervisor, Public Health Department of Wuhan University, Wuhan 430071, Hubei Province, China zfmao@126.com
  • About author:Qiu Jia-xuan☆, Studying for doctorate, Professor, Public Health Department of Wuhan University, Wuhan 430071, Hubei Province, China; Department of Stomatology, the Fourth Affiliated Hospital of Nanchang University, Nanchang 330003, Jiangxi Province, China qiujiaxuan@163.com
  • Supported by:

    Department of Science and Technology of Jiangxi Province, No. 2008BA04400*

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摘要：

背景：将化疗药物联接在磁性纳米载体上，在外加磁场的引导下使所载药物定向集中于靶向治疗部位，在增强疗效同时还可降低毒性不良反应。
目的：制备海藻酸钠改性的磁性纳米粒子及其负载顺铂药物，分析产物的磁学性质。
方法：通过Fe2+在乙醇胺水溶液中一步合成磁性纳米粒子，用海藻酸钠作偶联剂使磁性纳米粒子与顺铂相连，制备磁性纳米粒子药物。
结果与结论：X射线衍射花样证明产物为γ-Fe2O3纯相，透射电子显微镜表明磁性纳米粒子直径平均约10 nm，载顺铂后药物包覆于纳米粒子周围，磁化曲线显示纳米粒子为超顺磁性，核磁共振得到纳米粒子的弛豫率为0.116 02 mmol/ms。表明所制备磁性纳米粒子及其载顺铂超顺磁性纳米粒子药物性质稳定，具有作为磁性纳米粒子药物的特性。
关键词：磁性纳米粒子药物；顺铂；超顺磁性；Fe2O3；生物材料与药物控释
doi:10.3969/j.issn.1673-8225.2012.12.011

关键词:
磁性纳米粒子药物, 顺铂, 超顺磁性, Fe2O3, 生物材料与药物控释

Abstract:

BACKGROUND: Induced by external magnetic field, the chemotherapy drug loaded on magnetic nanocarrier can be directly collected on target therapy area, which will enhance the curative effect and reduce the toxicity and adverse reaction.
OBJECTIVE: To prepare sodium alginate-modified magnetic nanoparticles and cisplatin-loaded magnetic nanoparticle medicine, and to study the magnetic properties of the products.
METHODS: One-step reaction by the hydrolysis of Fe2+ in the aqueous solution of ethanolamine was employed for the preparation of magnetic nanoparticles. Sodium alginate was used as coupling agent to prepare magnetic nanoparticle medicine making magnetic nanoparticles and cisplatin interconnected.
RESULTS AND CONCLUSION: X-ray diffraction patterns proved that the product was pure γ-Fe2O3 phase. Transmission electron microscope images indicated that the average diameter of magnetic nanoparticles was about 10 nm, which were coated by cisplatin. Super paramagnetic behavior could be detected in the magnetization curve. A relaxation rate of 0.116 02 mmol/ms was obtained by nuclear magnetic resonance. The as-prepared magnetic nanoparticles and the cisplatin-loaded magnetic nanoparticle medicine showed a good stability, the physical properties of which revealed that it had the potential characteristics as magnetic nanoparticle targeted medicine.

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