中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (8): 1401-1406.doi: 10.3969/j.issn.1673-8225.2012.08.016

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

具有生物活性的高导复合支架材料制备表征及其生物相容性☆

周  岩1，程钢戈1，余新光2，张庆武3，黄永安1，董连强1，张宝国1，张  晖1，舒  成1   

  1. 1解放军空军总医院神经外科，北京市  100142；2解放军总医院神经外科，北京市   100853；3中国矿业大学(北京)，北京市  100083
  • 收稿日期:2011-08-08 修回日期:2011-09-20 出版日期:2012-02-19 发布日期:2012-02-19
  • 通讯作者: 余新光，博士，主任医师，教授，解放军总医院神经外科，北京市 100853 xinguang_yu@ 263.net
  • 作者简介:周岩☆，男，1974年生，吉林省长春市人，汉族，2008年军医进修学院解放军总医院毕业，博士，副主任医师，主要从事脊柱脊髓疾病和神经再生研究。zhouy1974@ hotmail.com

Preparation, characterization and biocompatibility of high-conductivity compound scaffolds containing biological activity

Zhou Yan1, Cheng Gang-ge1, Yu Xin-guang2, Zhang Qing-wu3, Huang Yong-an1, Dong Lian-qiang1, Zhang Bao-guo1, Zhang Hui1, Shu Cheng1   

  1. 1Department of Neurosurgery, Air Force General Hospital of Chinese PLA, Beijing  100142, China; 2Department of Neurosurgery, Chinese PLA General Hospital, Beijing  100853, China; 3China University of Mining and Technology (Beijing), Beijing  100083, China
  • Received:2011-08-08 Revised:2011-09-20 Online:2012-02-19 Published:2012-02-19
  • Contact: Yu Xin-guang, Doctor, Chief physician, Professor, Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China xinguang_yu@ 263.net
  • About author:Zhou Yan☆, Doctor, Associate chief physician, Department of Neurosurgery, Air Force General Hospital of Chinese PLA, Beijing 100142, China zhouy1974@ hotmail.com

PDF

342

摘要：

背景：组织工程新材料必须既能支持组织生长，又能激发理想的细胞反应(如血管发生)，而导电性则可促进包括神经在内的组织再生。
目的：构建一种新型材料，能将导电性和生物活性有效的结合起来，为组织工程提供一种理想的备选材料。
方法：将具有生物活性的透明质酸多糖和导电聚合物聚吡咯进行结合，制备具有生物活性的导电聚合物复合材料。
结果与结论：含有透明质酸多糖的聚吡咯/透明质酸双层膜具有光滑的表面形貌和良好的导电性。体外细胞相容性实验显示这种复合材料可显著促进神经轴突的延伸。体内实验显示该复合材料还具有良好的惰性和促血管生成效应，是一种较为理想的组织工程备选材料。

关键词: 导电聚合物, 聚吡咯, 透明质酸, 生物材料, 血管发生

Abstract:

BACKGROUND: New materials of tissue engineering can not only support the growth of tissues but also stimulate ideal cell response such as angiogenesis. Its conductivity can promote tissue regeneration included nerve.
OBJECTIVE: To prepare a new type of material that combines conductivity and biological activity as an ideal type of alternative material for tissue engineering.
METHODS: The bioactive polysaccharide hyaluronic acid (HA) was combined with the conductive polymer polypyrrole (PPy) to prepare conductive polymer composites containing biologically activity.
RESULTS AND CONCLUSION: PPy/HA bilayer films had the characters of smooth and conductivity. Cell compatibility experiments in vitro showed that the composites could promote the extension of axons. The composites had verified to have a good inertia and can promote the vascularization in vivo. PPy/HA composite biomaterials are suitable for tissue engineering.

中图分类号: