中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (7): 1299-1302.doi: 10.3969/j.issn.1673-8225.2012.07.037

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

中药促成骨细胞增殖和分化的机制与作用

陈述祥，康  乐   

  1. 江门市五邑中医院骨科(暨南大学医学院附属江门中医院)，广东省江门市   529031
  • 收稿日期:2011-07-14 修回日期:2011-09-12 出版日期:2012-02-12 发布日期:2012-02-12
  • 作者简介:陈述祥，男，1964年生，湖南省益阳市人，汉族，1986年衡阳医学院毕业，主任医师，主要从事骨关节外科、骨肿瘤、关节镜、运动医学、老年骨科的研究。kangletiger@yahoo.com.cn

Mechanism and effect of traditional Chinese medicine on promoting osteoblast proliferation and differentiation   

Chen Shu-xiang, Kang Le   

  1. Department of Orthopedics, Wuyi Traditional Chinese Medicine Hospital, (the Affiliated Jiangmen Traditional Chinese Medicine Hospital of Medicine College of Jinan University), Jiangmen  529031, Guangdong Province, China
  • Received:2011-07-14 Revised:2011-09-12 Online:2012-02-12 Published:2012-02-12
  • About author:Chen Shu-xiang, Chief physician, Department of Orthopedics, Wuyi Traditional Chinese Medicine Hospital, (the Affiliated Jiangmen Traditional Chinese Medicine Hospital of Medicine College of Jinan University), Jiangmen 529031, Guangdong Province, China kangletiger@yahoo.com.cn

PDF

341

被引次数

26

摘要：

背景：中药促进成骨细胞增殖和分化的效果已经得到肯定，其在细胞分子水平的药理机制研究取得了很大进展。
目的：对国内外应用中药诱导成骨细胞增殖和分化的药理机制研究进展作一综述。
方法：应用计算机检索CNKI，Pubmed和sciencedirect数据库中2001-01/2010-12关于中药促进成骨细胞增殖和分化机制研究的文章，在标题和摘要中以“中药，成骨细胞，增殖，分化，机制”或“Chinese herbs，osteoblast，proliferation，differentiation, mechanism”为检索词进行检索。初检得到176篇文献，最终选择30篇文献进行综述。
结果与结论：中药通过对成骨细胞基因、信号通路、细胞因子和OPG/RANK/RANKL系统的调控，以及类雌激素样作用促进成骨细胞增殖和分化，其作用机制明确，将中药引入骨组织工程领域具有良好的发展前景。
关键词：中药；成骨细胞；增殖；分化；机制；组织工程
doi:10.3969/j.issn.1673-8225.2012.07.037

关键词: 中药, 成骨细胞, 增殖, 分化, 机制, 组织工程

Abstract:

BACKGROUND: It is confirmed that traditional Chinese medicine can improve osteoblast proliferation and differentiation. Cell molecular research on the pharmacological mechanism behind this has made great progress.
OBJECTIVE: To summarize the research progress on the mechanisms of osteoblasts proliferation and differentiation induced by traditional Chinese medicine at home and abroad.
METHODS: An online search of CNKI, PubMed and ScienceDirect databases was performed for articles on the mechanism of osteoblast proliferation and differentiation induced by traditional Chinese medicine, published between January 2000 and December 2010, using keywords of “traditional Chinese herbs, osteoblasts, proliferation, differentiation and mechanism”. A total of 176 articles were collected after initial search, and 30 of them were retained.
RESULTS AND CONCLUSION: Traditional Chinese medicine can improve osteoblast proliferation and differentiation by regulating the genes, signal pathways, cytokines, OPG/RANK/RANKL system of osteoblasts and estrogen-like biological activities. The mechanism is clear. It has a good future prospect for the application of traditional Chinese medicine in bone tissue engineering.

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