中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (4): 748-751.doi: 10.3969/j.issn.1673-8225.2012.04.041

• 骨与关节临床实践 clinical practice of the bone and joint • 上一篇    下一篇

骨髓血移植结合髓芯减压治疗早期股骨头坏死：非随机对照*

覃学流，辛晓东，王大伟，陈跃平，林宗汉，韩  杰，覃  杰   

  1. 广西中医学院附属瑞康医院骨科，广西壮族自治区南宁市  530011
  • 收稿日期:2011-06-14 修回日期:2011-08-26 出版日期:2012-01-22 发布日期:2014-04-04
  • 通讯作者: Xin Xiao-dong, Master, Department of Orthopaedics, Affiliated Ruikang Hospital of Guangxi Traditional Chinese Medical University, Nanning 530011, Guangxi Zhuang Autonomous Region, China xinxin0403@hotmail.com
  • 作者简介:覃学流，男，1954年生，广西南宁市武鸣县人，壮族，1979年广西中医学院毕业，主任医师，主要从事骨关节创伤与疾病的临床研究工作。qinxueliu2008@163.com
  • 基金资助:

    广西卫生厅计划课题(Z2007134)。

Bone marrow transplantation and core decompression for treatment of early necrosis of the femoral head: A non-randomized controlled study  

Qin Xue-liu, Xin Xiao-dong, Wang Da-wei, Chen Yue-ping, Lin Zong-han, Han Jie, Qin Jie   

  1. Department of Orthopaedics, Affiliated Ruikang Hospital of GuangXi Traditional Chinese Medical University, Nanning  530011, Guangxi Zhuang Autonomous Region, China
  • Received:2011-06-14 Revised:2011-08-26 Online:2012-01-22 Published:2014-04-04
  • Contact: 辛晓东，硕士，广西中医学院附属瑞康医院骨科，广西壮族自治区南宁市 530011 xinxin0403@hotmail.com
  • About author:Qin Xue-liu, Chief physician, Department of Orthopaedics, Affiliated Ruikang Hospital of GuangXi Traditional Chinese Medical University, Nanning 530011, Guangxi Zhuang Autonomous Region, China qinxueliu2008@163.com
  • Supported by:

    Program Subject of Health Department of Guangxi Zhuang Autonomous Region, No. Z2007134*

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摘要：

背景：骨髓间充质干细胞移植治疗股骨头缺血性坏死成为近年研究的热门课题，而单纯髓芯减压治疗存在争议，那么当髓芯减压复合自体骨髓血移植联合治疗效果如何呢？
目的：探讨髓芯减压复合骨髓移植对治疗早期股骨头坏死的临床疗效。
方法：纳入采用髓芯减压复合浓集骨髓血移植治疗早期非创伤性股骨头坏死患者20例25髋设为治疗组，采用单纯髓芯减压20例23髋设为对照组。
结果与结论：随访6~36个月，根据蒋协远JOA髋关节功能判定标准及宾夕法尼亚州立大学骨坏死的放射学分期系统判定，治疗组总显效率达84%，对照组总显效率65%。髓芯减压复合骨髓移植治疗股骨头坏死，损伤小、疗效好，对早期股骨头坏死的患者能获得较好的临床疗效，远期疗效有待进一步探讨。

关键词: 自体骨髓移植, 骨髓, 骨髓间充质干细胞, 股骨头坏死, 髓芯减压, 总显效率

Abstract:

BACKGROUND: Bone marrow transplantation for the treatment of femoral head necrosis becomes a hot research topic in recent years, while the role of core decompression in the treatment is in dispute. The combined therapeutic effect of core decompression and bone marrow transplantation in treatment of femoral head necrosis is unclear.
OBJECTIVE: To explore the combined therapeutic effect of core decompression and bone marrow transplantation in treatment of early necrosis of the femoral head.
METHODS: Patients with early non-traumatic necrotic femoral head were included. Twenty of them with 25 hips treated by core decompression and concentrated bone marrow transplantation were taken as treatment group. Twenty patients with 23 hips in the control group underwent simple core decompression.
RESULTS AND CONCLUSION: Following 6-36 months follow-up, the total efficiency rate of the treatment group was 84% and that was 65% in the control group according to the hip function criteria of Japanese Orthopaedic Association and the Radiology Stage System of bone necrosis of Pennsylvania State University. Core decompression combined with bone marrow transplantation have better curative effects in treatment of early femoral head necrosis based on their small damage and good curative effects, however, their long-term effect is still unclear.

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