中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (2): 345-348.doi: 10.3969/j.issn.1673-8225.2012.02.035

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

牵张性脊髓损伤动物模型制备及评价★

吴  岳，邹国耀   

  1. 桂林医学院附属医院脊柱骨病科，广西壮族自治区桂林市   541001  
  • 收稿日期:2011-08-16 修回日期:2011-11-09 出版日期:2012-01-08 发布日期:2012-01-08
  • 通讯作者: 邹国耀，主任医师，教授，硕士生导师，桂林医学院附属医院脊柱骨病科，广西壮族自治区桂林市 541001 zhouguoyao2000@yahoo.com.cn
  • 作者简介:吴岳★，男，1985年生，广西壮族自治区玉林市人，汉族，在读硕士，主要从事脊柱骨病方面的研究。jzyue305@yahoo.com.cn

Establishment and evaluation of an animal model of tractive spinal cord injury 

Wu Yue, Zou Guo-yao   

  1. Department of Spinal Surgery, Affiliated Hospital of Guilin Medical University, Guilin  541001, Guangxi Zhuang Autonomous Region, China
  • Received:2011-08-16 Revised:2011-11-09 Online:2012-01-08 Published:2012-01-08
  • Contact: Zou Guo-yao, Chief physician, Professor, Master’s supervisor, Department of Spinal Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China zhouguoyao2000@yahoo.com.cn
  • About author:Wu Yue★, Studying for master’s degree, Department of Spinal Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China jzyue305@yahoo.com.cn

PDF

354

被引次数

14

摘要：

背景：建立牵张性脊髓损伤动物模型，对进一步探讨其病理生理改变及临床意义提供了良好的基础。
目的：就牵张性脊髓损伤动物模型的制备及评价方面做一综述。
方法：应用计算机检索CNKI和PubMed数据库中关于牵张性脊髓损伤动物模型的文章，在关键词中以“牵张性；脊髓损伤；动物模型；神经功能；运动功能”或“tractive, spinal cord injury, animal model, neural function, motor function”为检索词进行检索。选择文章内容与牵张性脊髓损伤相关，同一领域文献则选择近期发表或发表在权威杂志文章。初检得到285篇文献，根据纳入标准选择30篇文章进行综述。
结果与结论：脊髓损伤模型繁多，包括挫伤模型、压迫损伤模型、牵张性损伤模型、缺血损伤模型、横断损伤和化学损伤等。牵张性脊髓损伤动物模型的建立，对进一步探讨其病理生理改变及临床意义提供了良好的基础。
关键词：牵张性；脊髓损伤；动物模型；神经功能；运动功能
doi:10.3969/j.issn.1673-8225.2012.02.035

关键词: 牵张性, 脊髓损伤, 动物模型, 神经功能, 运动功能

Abstract:

BACKGROUND: Establishment of animal models of tractive spinal cord injury provides a good foundation for the further investigation on pathophysiological changes and clinical significance.
OBJECTIVE: To review the construction and evaluation of tractive spinal cord injury in animal models.
METHODS: A computer-based online search of CNKI and PubMed databases was performed for related articles about animal models of tractive spinal cord injury with the key words of “tractive, spinal cord injury, animal model, neural function and motor function” in Chinese and English. Articles relevant to tractive spinal cord injury was selected. As to the same field, articles published recently or in authoritative journals were of priority. A total of 285 articles were collected in the initial search, 30 of them were retained according to the inclusion criteria.
RESULTS AND CONCLUSION: There are various kinds of spinal cord injury experimental models, including contused model, compression model, traction model, ischemia model, cutting model and chemical injury model, etc. The establishment of animal models of tractive spinal cord injury provides a good foundation for the further investigation on pathophysiological changes and clinical significance.

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