中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (53): 10023-10026.doi: 10.3969/j.issn.1673-8225.2011.53.035

• 器官移植学术探讨 academic discussion of organ transplantation • 上一篇    下一篇

免疫抑制药物在抗移植排斥反应过程中的应用

张晓莉1，徐  莹2，李  勇3   

  1. 1寿光市中医院，山东省寿光市  262700
    2临朐县人民医院，山东省潍坊市 262601
    3诸城市人民医院药剂科，山东省潍坊市  262600
  • 收稿日期:2011-06-21 修回日期:2011-08-24 出版日期:2011-12-31 发布日期:2011-12-31
  • 通讯作者: 李勇，主管药师，诸城市人民医院药剂科，山东省潍坊市 262600
  • 作者简介:张晓莉，女，1977年生，山东省寿光市人，汉族，2001年山东大学药学院毕业，主要从事药学方面研究。 xu.chao@disha. cn

Application of immunosuppressants in graft rejective reaction

Zhang Xiao-li1, Xu Ying2, Li Yong3   

  1. 1Shouguang Hospital of Traditional Chinese Medicine, Shouguang  262700, Shandong Province, China
    2People’s Hospital of Linqu County, Weifang   262601, Shandong Province, China
    3Department of Pharmacy, People’s Hospital of Zhucheng, Weifang   262600, Shandong Province, China
  • Received:2011-06-21 Revised:2011-08-24 Online:2011-12-31 Published:2011-12-31
  • Contact: Li Yong, Pharmacist in charge, Department of Pharmacy, People’s Hospital of Zhucheng, Weifang 262600, Shandong Province, China
  • About author:Zhang Xiao-li, Shouguang Hospital of Traditional Chinese Medicine, Shouguang 262700, Shandong Province, China xu.chao@disha.cn

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618

被引次数

8

摘要：

背景：器官移植患者需要终生伴随免疫抑制剂，因此合理应用免疫抑制剂是器官移植成功的关键所在。
目的：对各类代表药物在器官移植中的应用作简要分析，拟为器官移植患者选择合适的免疫抑制剂。
方法：由第一作者检索1999-01/2011-06 PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)和万方数据库(http://www.wanfangdata.com.cn)。英文检索词为“immunosuppressive drug；reject reaction；cyclosporine A；tacrolimus(FK506)”，中文检索词为“免疫抑制剂，肾移植，肝移植，排斥反应”。检索文献量总计105篇，选择不同种类的免疫抑制药物在不同器官移植领域应用的特点及临床效果分析，排除陈旧及重复实验文章，同一领域文献则选择近期发表或发表在权威杂志的文章，最终纳入18篇符合标准的文献。
结果与结论：常见免疫抑制药分类：肾上腺皮质激素、代谢拮抗药、T淋巴细胞抑制药。然而每一种免疫抑制剂在发挥免疫抑制作用时都会伴有一定毒副反应，应尽量避免不良反应发生。如何利用免疫抑制药之间的协同作用，发挥最佳疗效是临床需进一步关注和研究的重点，应严密监测患者血药浓度，做到个体化用药，尽可能降低毒副反应发生率。

关键词: 免疫抑制剂, 肾移植, 肝移植, 排斥反应, 环孢素A, 吗替麦考酚酯, 他克莫司

Abstract:

BACKGROUND: Organ transplant patients require lifelong use of immunosuppressive reagent, so a rational use of immunosuppressive agents is the key to organ transplantation.
OBJECTIVE: To summarize various representative drugs in organ transplantation and to propose a suitable immunosuppressive agent for organ transplant patients.
METHODS: The first author searched PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and Wanfang Database (http://www.wanfangdata.com.cn) from 1999-01/2011-06. English key terms are “immunosuppressive drug, reject reaction, cyclosporine A, tacrolimus (FK506)”, and Chinese key terms are “immunosuppressive drugs, renal transplantation, liver transplantation, rejection”. A total of 105 documents were screened out, and those focusing on the application and clinical effectiveness of different immunosuppressive drugs in organ transplantation were included, while repeated experiments and old articles were excluded. Recently published articles or those published in the authority magazine were preferred in the same field, ultimately 20 literatures were involved in the final analysis.
RESULTS AND CONCLUSION: Common immunosuppressive drugs include the adrenal cortical hormone, metabolic antagonists, and T lymphocyte inhibitor. However, each immunosuppressant has certain toxic side effects when they are playing immunosuppressive effects, so side effects should be avoided. How to exhibit the synergic effect between the immunosuppressive drugs and to achieve the best clinical efficacy needs further attention. We should closely monitor blood concentration and give individual drug therapy, so as to lower incidence of toxic side effects.

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