中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (52): 9756-9759.doi: 10.3969/j.issn.1673-8225.2011.52.015

• 人工假体 artificial prosthesis • 上一篇    下一篇

老年患者骨水泥型人工髋关节置换前后的凝血功能

刘红兵1，杨留才2，孟庆兵1   

  1. 1盐城市第一人民医院骨科，江苏省盐城市 224005
    2盐城卫生职业技术学院，江苏省盐城市  224006
  • 收稿日期:2011-09-28 修回日期:2011-11-04 出版日期:2011-12-24 发布日期:2011-12-24
  • 作者简介:刘红兵，男，1967年生，江苏省盐城市人，汉族，2003年南京医科大学毕业，副主任医师，主要从事骨科疾病的诊治研究。 jsycylc@163.com

Changes of blood clotting in elderly patients prior to and after cemented hip replacement

Liu Hong-bing1, Yang Liu-cai2, Meng Qing-bing1   

  1. 1Department of Orthopedics, the First People’s Hospital of Yancheng, Yancheng  224005, Jiangsu Province, China
    2Yancheng Health Vocational and Technical College, Yancheng  224006, Jiangsu Province, China
  • Received:2011-09-28 Revised:2011-11-04 Online:2011-12-24 Published:2011-12-24
  • About author:Liu Hong-bing, Associate chief physician, Department of Orthopedics, the First People’s Hospital of Yancheng, Yancheng 224005, Jiangsu Province, China jsycylc@163.com

PDF

307

被引次数

6

摘要：

背景：由于老年患者自身的高凝倾向，骨水泥型人工髋关节置换后更容易发生深静脉栓塞、弥漫性血管内凝血、肺栓塞、脑栓塞等并发症。
目的：观察老年患者骨水泥型人工髋关节置换前后凝血4项凝血酶原时间、活化部分凝血活酶时间、凝血酶时间和纤维蛋白原的变化。
方法：检测40例人工髋关节置换老年患者骨水泥植入前10 min，植入后30 min、1 h、2 h、3 h 凝血酶原时间、活化部分凝血活酶时间、凝血酶时间和纤维蛋白原各项指标。
结果与结论：与植入前10 min比较，植入后30 min凝血酶原时间明显下降(P < 0.05)，纤维蛋白原明显升高(P < 0.05)，植入后3 h均恢复到植入前状态(P > 0.05)。活化部分凝血活酶时间、凝血酶时间在骨水泥植入前后变化均不明显(P > 0.05)。结果表明患者在骨水泥植入后短时间内会出现高凝血状态，在植入3 h后基本消除，提示在植入骨水泥后的3 h是监测凝血的重要时间段。

关键词: 凝血功能, 髋关节, 关节置换, 凝血酶原时间, 活化部分凝血活酶时间, 血浆凝血酶时间, 纤维蛋白原

Abstract:

BACKGROUND: As the high blood clotting of the elderly patients, the complications may occur more easily after cemented hip replacement, such as deep venous embolism, disseminated intravascular coagulation, pulmonary embolism and cerebral embolism.
OBJECTIVE: To explore the changes of four blood clots index, such as the prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB) after cemented hip replacement in elderly patients.
METHODS: The PT, APTT, TT and FIB of 40 elderly patients with artificial hip replacement was detected at 10 minutes before implantation and 30 minutes, 1, 2, 3 hours after implantation, respectively.
RESULTS AND CONCLUSION: Compared with 10 minutes before implantation, the PT of 30 minutes after implantation was significantly decreased (P < 0.05), and the FIB was increased obviously (P < 0.05), and restored to the normal state at 3 hours after implantation (P > 0.05). The changes of APTT and TT before and after implantation were not significant (P > 0.05). The results showed that there were high blood clots in a short time after bone cement implantation, and disappeared at 3 hours after implantation. Three hours after bone cement implantation was the best time to detect the blood clots.

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