中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (42): 7881-7884.doi: 10.3969/j.issn.1673-8225.2011.42.022

• 生物材料循证医学 evidence-based medicine of biomaterials • 上一篇    下一篇

可降解脑血管支架材料生物相容性的系统评价

瞿  浩1，李  玫1，袁  萍2，郭  琴3   

  1. 1贵州省人民医院神经内科，贵州省贵阳市 550000
    2重庆医科大学儿科学院，重庆市  400020
    3广州中医药大学第二临床医学院，广东省广州市  510405
  • 收稿日期:2011-08-01 修回日期:2011-09-16 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 李玫，贵州省人民医院神经内科，主任医师，贵州省贵阳市 550000 gychenlan2011@gmail.com
  • 作者简介:瞿浩，1967年生，浙江省杭州市人，汉族，1989年徐州医学院毕业，副主任医师，主要从事脑血管疾病基础和临床研究。 gychenlan2011@gmail.com

Systematical evaluation for the biocompatibility of biodegradable cerebrovascular stent materials

Qu Hao1, Li Mei1, Yuan Ping2, Guo Qin3   

  1. 1Department of Neurology, Guizhou Provincial People’s Hospital, Guiyang  550000, Guizhou Province, China
    2Pediatric School of Chongqing Medical University, Chongqing  400020, China
    3Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou  510405, Guangdong Province, China
  • Received:2011-08-01 Revised:2011-09-16 Online:2011-10-15 Published:2011-10-15
  • Contact: Li Mei, Chief physician, Department of Medical Cadres, Guizhou Provincial People’s Hospital, Guiyang 550000, Guizhou Province, China gychenlan2011@ gmail.com
  • About author:Qu Hao, Associate chief physician, Department of Neurology, Guizhou Provincial People’s Hospital, Guiyang 550000, Guizhou Province, China gychenlan2011@ gmail.com

PDF

361

被引次数

10

摘要：

背景：选择和开发具有良好生物相容性的脑血管支架材料是目前研究的热点。
目的：系统评价可降解脑血管支架材料生物相容性的相关文献，客观分析生物可降解支架置入的安全性及预后。
方法：计算机检索EMbase(1980/2011-08)、MEDLINE(1966/2011-08)、中国生物医学文献数据库(CBM，1978/2011-08)、中文学术期刊全文数据库(CNKI)有关可降解脑血管支架生物相容性的动物实验和临床试验的文献，进行可归纳总结。
结果与结论：共纳入24篇文章，15篇有关可降解脑血管支架材料生物相容性的动物实验结论均显示，多种可降解脑血管支架材料可抑制内膜增生，防止血栓形成，再狭窄发生率低，生物相容性良好；9篇有关可降解脑血管支架材料生物相容性的临床应用文章显示，可降解脑血管支架可减少再狭窄，改善患者预后，其安全性能尚待更长期的观察。提示可降解脑血管支架材料具有良好的生物相容性，作为支架置入材料应用于脑血管疾病的治疗具有较高的安全性及有效性，其减少再狭窄率的长期疗效有待于进一步观察。

关键词: 脑血管支架, 可降解, 生物相容性, 再狭窄, 生物材料

Abstract:

BACKGROUND: To select and develop cerebrovascular stent materials with a good biocompatibility is currently a hot research
OBJECTIVE: To systematically evaluate the biocompatibility of biodegradable cerebrovascular stent materials, and to analyze the safety and prognosis after stent implantation.
METHODS: A computer-based online search of EMbase (1980/2011-08), MEDLINE (1966/2011-12), CBM (1978/2011-08) and CNKI were performed for articles about animal experiments and clinical applications focusing on the biocompatibility of biodegradable cerebrovascularr stent materials. 
RESULTS AND CONCLUSION: Of 24 selected articles, 15 related animal experiments results show that various types of biodegradable cerebrovascularstent with good biocompatibility have favorable effects on preventing vascular thrombosis and restenosis by suppressing endometrial hyperplasia. Nine related clinical experiments results show that biodegradable cerebrovascular stents can decrease the rate of restenosis and improve patients’ prognosis; however, the safety needs long-term studies. Biodegradable cerebrovascular stent materials with good biocompatibility are effective and safe for cerebrovascular diseases. Further studies with long-term follow-up are required to assess the restenosis rates in the intracranial vasculature.

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