中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (7): 1264-1268.doi: 10.3969/j.issn.1673-8225.2011.07.028

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

蜂胶生物效应的细胞学机制

李  园1，丁仲鹃2   

  1. 1昆明医学院，云南省昆明市 650031
    2昆明医学院附属口腔医院口腔修复科，云南省昆明市 650031
  • 收稿日期:2010-10-14 修回日期:2010-11-25 出版日期:2011-02-12 发布日期:2011-02-12
  • 通讯作者: 丁仲鹃，博士，主任医师，硕士生导师，博士生导师，昆明医学院附属口腔医院口腔修复科，云南省昆明市 650031 dingzhongjuan@sina.com
  • 作者简介:李园★，女，1983年生，山西省长治市人，汉族，昆明医学院在读硕士，主要从事口腔修复和种植学研究。 Liyuan-bing@ 163.com
  • 基金资助:

    国家自然科学基金资助项目(30960424)。

Cellular mechanism of biological activity of propolis 

Li Yuan1, Ding Zhong-juan2   

  1. 1Kunming Medical University, Kunming  650031, Yunnan Province, China
    2Department of Prosthodontics, the Affiliated Stomatology Hospital of Kunming Medical College, Kunming 650031, Yunnan Province, China
  • Received:2010-10-14 Revised:2010-11-25 Online:2011-02-12 Published:2011-02-12
  • Contact: Ding Zhong-juan, Doctor, Chief physician, Master’s supervisor, Doctoral supervisor, Department of Prosthodontics, the Affiliated Stomatology Hospital of Kunming Medical College, Kunming 650031, Yunnan Province, China dingzhongjuan@sina.com
  • About author:Li Yuan★, Studying for master’s degree, Kunming Medical University, Kunming 650031, Yunnan Province, China Liyuan-bing@163. com
  • Supported by:

    the National Natural Science Foundation of China, No. 30960424*

PDF

540

被引次数

10

摘要：

背景：蜂胶是一种天然活性物质，具有抗肿瘤，抗氧化，抗炎，免疫调节，治疗糖尿病以及保肝护肝的作用，其对细胞的作用机制是目前研究的热点之一。
目的：从细胞水平综合分析蜂胶对细胞的药理作用机制。
方法：计算机检索中国期刊全文数据以及PubMed数据库1977/2010相关文章，检索词为“蜂胶，抗肿瘤，抗氧化，抗炎，免疫调节，糖尿病，肝，propolis，antitumor，antioxidant，antiinflammatory，immunoregulation，diabetes mellitus，hepatocyte”。纳入与蜂胶对细胞作用机制有关的文献。排除与研究目的无关和内容重复者。
结果与结论：共纳入47篇文献，总结了蜂胶对多种细胞可能的作用机制。蜂胶作为高效纯天然药物具有广泛的药理作用，可抗氧化、消除自由基、调节炎症因子等途径作用于细胞，对细胞起保护和修复作用、调节细胞活性、影响细胞因子的分泌。

关键词: 蜂胶, 抗肿瘤, 自由基, 糖尿病, 保肝护肝, 药理作用机制, 细胞, 综述文献

Abstract:

BACKGROUND: Propolis, a natural product collected by honey bees, possesses variety biological effects, such as anti-tumor, antioxidant, anti-inflammatory, immunomodulatory, treating diabetes mellitus, as well as hepatoprotective effect. The cellular mechanism of biological activity of propolis are research focuses.
OBJECTIVE: To analyze pharmacological mechanisms of propolis on cells from a cellular level.
METHODS: A computer-based online search was conducted in China Academic Journals Database and PubMed with the key words of “propolis, antitumor, antioxidant, antiinflammatory, immunoregulation, diabetes mellitus, hepatocyte”, both in English and Chinese from 1977 to 2010 to retrieve articles on pharmacological mechanisms of propolis on cells. Literatures of irrelevant purpose and repetitive content were excluded. 
RESULTS AND CONCLUSION: Totally 47 literatrue were included. The pharmacological mechanisms of propolis on cells were summarized. As a natural drug, Propolis can protect and repair cells, regulate cell viability and influence cytokine secretion from pathways of antioxidant, eliminate free radical, or regulate inflammatory factor.

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