中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (50): 9442-.doi: 10.3969/j.issn.1673-8225.2010.50.033

• 组织构建学术探讨 • 上一篇    下一篇

正常及异常组织中雌激素α及β受体的表达

李联祥1，王黎光2，申育华3，高金生1   

  1. 河北工程大学医学院，1组织胚胎学教研室，基础医学实验室；2生理学教研室，人体机能实验室，河北省邯郸市 056029；3邯郸市第三医院眼科，河北省邯郸市056002
  • 出版日期:2010-12-10 发布日期:2010-12-10
  • 作者简介:李联祥，男，1955年生，河北省辛集市人，汉族，1977年承德医学院毕业，教授，主要从事眼分子生物学及眼组织病理学研究。 lianxianglm@ sohu.com
  • 基金资助:

    河北省科技支撑计划项目(10276105D-3)。

Expression of estrogen receptor alpha and beta in normal and abnormal tissues

Li Lian-xiang1, Wang Li-guang2, Shen Yu-hua3, Gao Jin-sheng1   

  1. 1 Laboratory of Basic Medical Science, Department of Histology and Embryology, 2 Laboratory of Body Function, Department of Physiology, Medical College of Hebei University of Engineering, Handan  056029, Hebei Province, China; 3Department of Ophthalmology, Third Hospital of Handan, Handan  056002, Hebei Province, China
  • Online:2010-12-10 Published:2010-12-10
  • About author:Li Lian-xiang, Professor, Laboratory of Basic Medical Science, Department of Histology and Embryology, Medical College of Hebei University of Engineering, Handan 056029, Hebei Province, China lianxianglm@ sohu.com
  • Supported by:

    the Key Technology Research & Development Program of Hebei Province, No. 10276105D-3*

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摘要：

背景：随着雌激素β受体亚型的发现，对重新认识雌激素α，β受体的信号转导途径及作用机制提出了新的课题，深入研究雌激素α，β受体的结构、生理功能和相关依赖性疾病具有重要意义。
目的：总结雌激素α，β受体在正常组织和异常组织的表达以及病理生理作用。
方法：应用电子计算机检索PubMed数据库和CNKI数据库及PubMed数据库2000-01/2010-05雌激素受体相关综述和论文报告，纳入与雌激素α，β受体结构和功能密切相关的文献，和与雌激素α，β受体在正常不同组织器官和病理组织表达的基础研究和临床实验研究文献。排除重复性实验。
结果与结论：符合纳入标准的38篇，结果表明雌激素α，β受体广泛分布在不同组织中，其结构和功能存在着差异，雌激素及其受体通过基因调节机制和非基因调节机制对靶组织产生效应。雌激素α，β受体在不同的组织器官和不同疾病的组织中表达比例和水平存在着差异，即使同一器官内不同的组织细胞表达比例也存在差异。

关键词: 雌激素, 受体, 组织分布, 表达量, 病理生理学

Abstract:

BACKGROUND: As estrogen receptors subtype of β, the signal transduction pathway and mechanism of action of the estrogen receptors α and β are new topics. It has great significant to in-depth research of structure, function of the estrogen receptors α and β as well as its related dependent disease.
OBJECTIVE: To summarize the expression of estrogen receptor α and β in normal and abnormal tissues and its pathophysiology.
METHODS: A computer-based online search of PubMed CNKI databases was undertaken to identify the articles regarding estrogen receptors published between January 2000 and May 2010. Literatures related to structure and function of estrogen receptor α and β, or studies concerning estrogen receptor α and β in normal and abnormal tissues were included. Repetitive studies were excluded.
RESULTS AND CONCLUSION: Totally 38 papers were analyzed according to the inclusive criteria. Estrogen receptor α and β are widely distributed in different tissues with variation in structure and functions, that signal transduction through its receptor influence function of the target, there are differences between the expression ratio and level in normal tissues of different organs and tissues in different diseases, even the tissue cells in different of same organ are different in expression proportion of estrogen receptor α and β.

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