中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (11): 1907-1910.doi: 10.3969/j.issn.1673-8225.2010.11.002

• 软骨组织构建 cartilage tissue construction • 上一篇    下一篇

人气管软骨的拉伸力学特性

陈 树1，郭喜平1，吕雅平2，马洪顺3   

  1. 1吉林大学第二医院，吉林省长春市 130027；
    2大庆石油学院机械科学与工程学院，黑龙江省大庆市 163308；
    3吉林大学南岭校区工程力学系，吉林省长春市  130022
  • 出版日期:2010-03-12 发布日期:2010-03-12
  • 通讯作者: 通讯作者：马洪顺，教授，吉林大学南岭校区工程力学系，吉林省长春市 130022 mahs@jlu.edu.cn
  • 作者简介:陈 树，男，1976年生，吉林省长春市人，汉族，2001年吉林大学毕业，硕士，主治医师，主要从事胸外科临床与生物力学研究。

Tensile mechanical properties of human tracheal cartilage

Chen Shu1, Guo Xi-ping1, Lü Ya-ping2, Ma Hong-shun3   

  1. 1Jilin University Second Hospital, Changchun   130027, Jilin Province, China;
    2Mechanical Science and Engineering College, Daqing Petroleum Institute, Daqing   163308, Heilongjiang Province, China;
    3Enginnering Mechanics Department, Jilin University Nanling Campus, Changchun   130022, Jilin Province, China
  • Online:2010-03-12 Published:2010-03-12
  • Contact: Ma Hong-shun, Professor, Enginnering Mechanics Department, Jilin University Nanling Campus, Changchun 130022, Jilin Province, China mahs@jlu.edu.cn
  • About author:Chen Shu, Master, Attending physician, Jilin University Second Hospital, Changchun 130027, Jilin Province, China

PDF

668

被引次数

14

摘要：

背景：气管损伤缝合与新型人工气管的研制都需要了解气管软骨的拉伸力学特性以修复、重建气管功能。以往的国内外研究对人工气管的生物力学报道较多，而对人气管软骨生物力学的报道较少。
目的：以一维拉伸实验方法观察气管软骨的力学性质。
方法：正常人新鲜尸体气管标本2个，标本获取征得家属同意。取出标本，在常温下解冻，以手术刀切取气管软骨试样标本加工成试样长度25 mm，宽度5 mm，厚度1.8~2.2 mm试样20个，在日本岛津电子万能试验机上对20个气管软骨试样进行一维拉伸实验，拉伸实验速度为5 mm/min。观察试件拉伸最大载荷、最大位移、最大应力、最大应变、弹性模量、应力-应变曲线。
结果与结论：人尸体气管软骨最大载荷为(60.946±10.377)N，最大位移为(1.973±0.159)mm，最大应力为(6.229±1.125)MPa，最大应变为(32.825±2.776)%。气管软骨的应力-应变曲线为指数关系变化的，曲线最初的低坡部分是由于施加拉力的方向与胶原蛋白结构的排列一致，曲线的陡峭部分代表胶原蛋白本身的拉伸刚度。为描述气管软骨一维拉伸中的应力-应变关系，对气管软骨实验数据各取15个点应力-应变数据采用多项式，以最小二乘法进行拟合，得出应力(δ)-应变(ε)关系式实验结果显示，气管软骨具有较强的承受载荷和抵抗变形能力，反映其具有黏性又有弹性的黏弹性力学特性，支持软骨的力学性质与软骨胶原含量呈正相关的观点。

关键词: 气管软骨, 一维拉伸, 应力, 应变, 软骨组织工程

Abstract:

BACKGROUND: Tracheal injury suture and the development of a new tracheal prosthesis all need to understand the tensile mechanical properties of tracheal cartilage, so as to repair and rebuild tracheal function. Previous researches on the biomechanics of artificial trachea are many reported, while the biomechanics of human tracheal cartilage is reported less.
OBJECTIVE: To investigate the mechanical properties of tracheal cartilage using one-dimensional tensile test method.
METHODS: Two fresh cadaver specimens of normal human trachea, with the informed consents of their families, were involved. The specimens were thaw at room temperature, and then tracheal cartilage specimens were cut using scalpel into 20 samples at the length of 25 mm, width 5 mm, thickness 1.8-2.2 mm. The 20 tracheal cartilage samples were subjected to one-dimensional tensile test with Shimadzu electronic universal testing machine Japan, at the tensile test speed of 5 mm/min. The tensile maximum load, maximum displacement, maximum stress, maximum strain, elastic modulus and stress-strain curve of the specimens were observed.
RESULTS AND CONCLUSION: The maximum load of human cadaver tracheal cartilage was (60.946±10.377) N, maximum displacement was (1.973±0.159) mm, maximum stress was (6.229±1.125) MPa, maximum strain was (32.825±2.776)%. Tracheal cartilage stress-strain curves was changed along with the index, the initial low slope of the curve was due to the direction of imposed tension was similar with the arrangement of collagen structure, the steep slope represented the tensile strength of collagen. To describe the tracheal cartilage stress-strain relationship in a one-dimensional tension, 15 stress-strain data of the tracheal cartilage experimental data adopted polynomial by the least square fitting method, to obtain stress (δ) - strain (ε) relationship formula:  . It is indicated that tracheal cartilage has a strong capacity to bear load and resist deformation, reflecting their viscoelastic mechanical properties of both flexibility and viscosity, supporting that the mechanical properties of cartilage is positively related to cartilage collagen content.

中图分类号: