关键词: 阻塞性睡眠呼吸暂停, 急性冠状动脉综合征, 介入治疗, 定量冠状动脉血管造影, 再狭窄, 心血管植入物

Abstract:

BACKGROUND: Multiple studies have shown that obstructive sleep apnea is correlated with cardiovascular diseases, and plays an important role in occurrence and development of cardiovascular diseases. Nevertheless, we have little knowledge about effects of obstructive sleep apnea on results and prognosis of coronary artery interventional therapy.

OBJECTIVE: To investigate the effect of obstructive sleep apnea on restenosis in patients undergoing successful coronary artery stent implantation.

METHODS: A total of 76 patients with acute coronary syndrome (ACS) were selected, including 59 males and 17 females, with an average age of (67±10) years, at the Department of Cardiology, Xingtai Municipal People’s Hospital from January 2005 to December 2008. There were 45 patients with acute myocardial infarction and 31 patients with unstable angina pectoris. All patients were subjected to coronary artery stent implantation, coronary angiography. The coronary lesion cases and Gensini grades were recorded. Of them, 63 patients received coronary artery interventional therapy. All patients underwent polysomnography. The results of quantitative coronary angiography were analyzed in the course of operation and at 6-months following-up.

RESULTS AND CONCLUSION: A total of 37 of the 76 patients had obstructive sleep apnea. The prevalence of multivessel disease was 51% and Gensini grades was 23.6±20.7, which was higher than patients without obstructive sleep apnea (P = 0.004). There were no significant differences between the two groups for median reference vascular diameter, median lesion length before operation, acute gain besides minimum lumen diameter after operation (P > 0.05). The rate of coronary artery in stent restenosis in patients with obstructive sleep apnea was 37%, which was higher than patients without obstructive sleep apnea over a 6-month follow-up (P = 0.021).