中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (6): 978-984.doi: 10.3969/j.issn.2095-4344.1571

• 生物材料综述 biomaterial review • 上一篇    

依维莫司药物洗脱支架的发展进程

凌 浩1,王 宝2,吴莉侠1,闫 会1,宋春莉1   

  1. 1吉林大学第二医院心血管内科,吉林省长春市 130012;2吉林省辽源市东辽县人民医院内科,吉林省辽源市 136600
  • 收稿日期:2018-11-05 出版日期:2019-02-28 发布日期:2019-02-28
  • 通讯作者: 宋春莉,医学博士,主任医师,博士生导师,吉林大学第二医院,吉林省长春市 130012
  • 作者简介:凌浩,男,1995 年生,汉族,山东省潍坊市人,吉林大学第二医院在读硕士,主要从事冠状动脉粥样硬化性心脏病与支架研究。
  • 基金资助:

    吉林省发改委产业技术研究与开发项目(2016C044-2),项目负责人:宋春莉;吉林省教育厅十三五科学技术研究项目(JJKH20180104KJ),项目负责人:宋春莉;吉林省财政厅卫生专项项目,项目负责人:宋春莉;吉林省新型冠脉支架科技创新中心(JKFC2017250),项目负责人:宋春莉

Development of everolimus-eluting stents

Ling Hao1, Wang Bao2, Wu Lixia1, Yan Hui1, Song Chunli1   

  1. 1Department of Cardiovascular Medicine, Second Hospital of Jilin University, Changchun 130012, Jilin Province, China; 2Department of Internal Medicine, Dongliao People’s Hospital, Liaoyuan 136600, Jilin Province, China
  • Received:2018-11-05 Online:2019-02-28 Published:2019-02-28
  • Contact: Song Chunli, MD, Chief physician, Doctoral supervisor, Department of Cardiovascular Medicine, Second Hospital of Jilin University, Changchun 130012, Jilin Province, China
  • About author:Ling Hao, Master candidate, Department of Cardiovascular Medicine, Second Hospital of Jilin University, Changchun 130012, Jilin Province, China
  • Supported by:

    the Industrial Technology Research and Development Project of Jilin Provincial Development and Reform Commission, No. 2016C044-2 (to SCL); the 13th Five-Year Scientific and Technological Research Project of Jilin Provincial Education Department, No. JJKH20180104KJ (to SCL); the Special Health Project of Jilin Provincial Finance Department in 2018 (to SCL); a grant from Jilin Provincial New Coronary Stent Technology Innovation Center, No. JKFC2017250 (to SCL)

摘要:

文章快速阅读:

 

文题释义:
依维莫司:依维莫司是哺乳动物雷帕霉素靶蛋白丝氨酸/苏氨酸激酶信号转导途径的蛋白激酶抑制剂。
依维莫司药物洗脱支架:是由具有生物相容性金属材料等组成洗脱依维莫司的支架,可以有效的减少支架内再狭窄和血栓发生率。
 
 
背景:药物洗脱支架将金属支架的机械支架性能与一种抗增殖药物的特异性结合起来,能够有效的减少支架对血管的损伤、支架内再狭窄和血栓的发生率,并降低晚期不良事件的风险。
目的:探索依维莫司药物洗脱支架研究进展。
方法:以“依维莫司;everolimus;stent;drug-eluting stents;everolimus drug-eluting stents”等为关键词,在中国知网数据库、PubMed、EMBAES 数据库中进行检索,排除与文章不相关的、老旧的、重复的文献,对保留的61篇文献进行归纳、分析与总结。

结果与结论:依维莫司药物洗脱支架目前临床上以钴铬依维莫司药物洗脱支架最为常见,可有效抑制内膜增生和炎症反应发生,减少支架内血栓的发生率。虽然新型依维莫司药物洗脱支架的出现解决了依维莫司药物洗脱支架的一些问题,如血小板黏附、平滑肌细胞增殖、血管舒缩及血管内皮细胞活性,但还有一些问题需要继续研究。

ORCID: 0000-0002-7796-5308(凌浩)

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

关键词: 依维莫司, 钴铬合金, 药物洗脱, 血管支架, 冠状动脉粥样硬化性心脏病, 血小板黏附, 支架内再狭窄

Abstract:

BACKGROUND: Drug-eluting stents, which combine the mechanical properties of metal stents with the specificity of an anti-proliferative drug, can effectively reduce the incidence of stent injury, restenosis and thrombosis, and reduce the risk of late adverse events.

OBJECTIVE: To review the progress of everolimus-eluting stents.
METHODS: The key words of “everolimus, stent, drug-eluting stents, everolimus drug-eluting stents” were used for literature retrieval in CNKI, PubMed and EMBASE databases. Unrelated, old and duplicated literatures were excluded, and 61 retained literatures were summarized, analyzed and summarized.
RESULTS AND CONCLUSION: Cobalt chromium-everolimus eluting stent is the most common everolimus-eluting stent, which can effectively inhibit intimal hyperplasia and inflammation and reduce the incidence of stent thrombosis. Although the emergence of new everolimus-eluting stents has solved some problems of existing everolimus-eluting stents, such as platelet adhesion, smooth muscle cell proliferation, vasomotion and vascular endothelial cell viability, there are still some problems that need to be further studied.  

Key words: Coronary Artery Disease, Stents, Tissue Engineering

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