中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (6): 1088-1091.doi: 10.3969/j.issn.1673-8225.2010.06.029

• 干细胞综述 • 上一篇    下一篇

干细胞与运动性骨骼肌细胞凋亡

屈红林，王  勇   

  1. 江西省宜春学院体育学院理论教研室，江西省宜春市 336000
  • 出版日期:2010-02-05 发布日期:2010-02-05
  • 作者简介:屈红林，男，1980年生，汉族，山东省菏泽市人，2006年广西师范大学毕业，硕士，讲师，主要从事运动医学方面的研究。 quhonglin20040125@126.com

Stem cells and exercise-induced skeletal muscle cell apoptosis

Qu Hong-lin, Wang Yong   

  1. Teaching and Research Section of Theory, Physical Education Institute of Yichun University, Yichun   366000, Jiangxi Province, China
  • Online:2010-02-05 Published:2010-02-05
  • About author:Qu Hong-lin, Master, Lecturer, Teaching and Research Section of Theory, Physical Education Institute of Yichun University, Yichun 366000, Jiangxi Province, China quhonglin20040125@126.com

PDF

507

被引次数

7

摘要：

背景：运动性骨骼肌细胞凋亡业已成为当前运动医学领域的研究重点，干细胞应用于运动性伤病的恢复和防治也有报道，但将干细胞用于细胞凋亡干预作用的相关研究还很少。

目的：总结干细胞防治运动性骨骼肌细胞凋亡的作用及其机制，为科学的运动训练和体育锻炼提供依据。

方法：通过计算机检索PubMed数据库1991-01/2009-10的相关文献，检索词为“Exercise Training，Sports，Skeletal Muscle，Apoptosis”，并限定文章语言种类为English。同时计算机检索中国期刊全文数据库1994-01/2009-10的相关文献，检索词“干细胞、运动、骨骼肌、细胞凋亡”，并限定文章语言种类为中文。纳入标准：①文章所述内容应与干细胞及其骨骼肌细胞凋亡的研究密切相关。②同一领域选择近期发表或在权威杂志上发表的文章。排除标准：①重复性研究。②Meta分析。

结果与结论：共检索到360篇文献，对资料进行初审，文献的来源主要是通过对干细胞及其在运动医学领域的研究进展，以及骨骼肌细胞凋亡的变化与发展趋势等的应用情况进行汇总分析，共选取31篇文献，其中21篇为综述，其余均为临床或基础实验研究。大强度的运动可引起骨骼肌细胞出现凋亡，而运用干细胞技术可在一定程度上起到预防细胞凋亡的作用，干细胞可通过调节Bcl-2和Bax蛋白表达来防治运动过程中出现的骨骼肌细胞凋亡，从而促进运动机体骨骼肌的早期恢复。

关键词: 运动, 骨骼肌, 细胞凋亡, Bcl-2蛋白, Bax蛋白, 干细胞

Abstract:

BACKGROUND: Exercise-induced skeletal muscle apoptosis has been referred to as the current focus of sports medicine, and the application of stem cells in athletic injury rehabilitation and prevention has been reported. However, the role of stem cells in cell apoptosis remains unclear.

OBJECTIVE: To summarize the effect and mechanism of stem cells in preventing exercise-induced skeletal muscle apoptosis to provide references for scientific sports training and physical activity.

METHODS: A computer-based online search of PubMed (1991-01/2009-10) and CNKI (1994-01/2009-10) was performed for related articles with the keywords “"Exercise Training, Sports, Skeletal Muscle, Apoptosis" in English and "stem cells, exercise, skeletal muscle, apoptosis," in Chinese. Inclusion criteria: ① studies on stem cells and their apoptosis in skeletal muscle cells; ②articles in the same field published recently or in the authoritative journals. Exclusion criteria: ① Repetitive articles; ② Meta analysis.

RESULTS AND CONCLUSION: A total of 360 articles were collected from the summary of literature through the stem cells and its application in the field of sports medicine research, and its skeletal muscle apoptosis in the changes and development trend of the application. Finally, 31 articles were included, including 21 reviews and 10 clinical or experimental studies. High-intensity exercise can cause apoptosis in skeletal muscle cells, while the use of stem cell technology can prevent apoptosis, to a certain extents by regulating Bcl-2 and Bax protein expression, thereby promoting the early recovery of skeletal muscle.

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