[1] BOSSONE E, EAGLE KA. Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes. Nat Rev Cardiol. 2021;18(5):331-348.
[2] GUO DC, PAPKE CL, HE R, et al. Pathogenesis of thoracic and abdominal aortic aneurysms. Ann N Y Acad Sci. 2006;1085:339-352.
[3] RYER EJ, RONNING KE, ERDMAN R, et al. The potential role of DNA methylation in abdominal aortic aneurysms. Atherosclerosis. 2015;241(1): 121-129.
[4] HAN Y, TANIOS F, REEPS C, et al. Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm. Clin Epigenetics. 2016;8:3.
[5] MAEGDEFESSEL L, SPIN JM, RAAZ U, et al. miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development. Nat Commun. 2014;5:5214.
[6] OSPELT C. A brief history of epigenetics. Immunol Lett. 2022;249:1-4.
[7] PEIXOTO P, CARTRON PF, SERANDOUR AA, et al. From 1957 to nowadays: a brief history of epigenetics. Int J Mol Sci. 2020;21(20):7571.
[8] ROMBOUTS KB, VAN MERRIENBOER TAR, KET JCF, et al. The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections. Eur J Clin Invest. 2022;52(4):e13697.
[9] GOLLEDGE J, MULLER J, DAUGHERTY A, et al. Abdominal aortic aneurysm: pathogenesis and implications for management. Arterioscler Thromb Vasc Biol. 2006;26(12):2605-2613.
[10] WANHAINEN A, VERZINI F, VAN HERZEELE I, et al. Editor’s Choice -European Society for Vascular Surgery (ESVS). 2019 Clinical Practice Guidelines on the Management of Abdominal Aorto-iliac Artery Aneurysms. Eur J Vasc Endovasc Surg. 2019;57(1):8-93.
[11] ALTOBELLI E, RAPACCHIETTA L, PROFETA VF, et al. Risk factors for abdominal aortic aneurysm in population-based studies: a systematic review and meta-analysis. Int J Environ Res Public Health. 2018;15(12):2805.
[12] GRØNDAL N, SØGAARD R, LINDHOLT JS. Baseline prevalence of abdominal aortic aneurysm, peripheral arterial disease and hypertension in men aged 65-74 years from a population screening study (VIVA trial). Br J Surg. 2015;102(8):902-906.
[13] TANG W, YAO L, ROETKER NS, et al. Lifetime risk and risk factors for abdominal aortic aneurysm in a 24-year prospective study: theARIC Study (Atherosclerosis Risk in Communities). Arterioscler Thromb Vasc Biol. 2016;36(12):2468-2477.
[14] SAKALIHASAN N, DEFRAIGNE JO, KERSTENNE MA, et al. Family members of patients with abdominal aortic aneurysms are at increased risk for aneurysms: analysis of 618 probands and their families from the Liège AAA Family Study. Ann Vasc Surg. 2014;28(4):787-797.
[15] VATS S, SUNDQUIST K, WANG X, et al. Associations of global DNA methylation and homocysteine levels with abdominal aortic aneurysm: a cohort study from a population-based screening program in Sweden. Int J Cardiol. 2020;321:137-142.
[16] TOGHILL BJ, SARATZIS A, HARRISON SC, et al. The potential role of DNA methylation in the pathogenesis of abdominal aortic aneurysm. Atherosclerosis. 2015;241(1):121-129.
[17] JABŁOŃSKA A, ZAGRAPAN B, PARADOWSKA E, et al. Abdominal aortic aneurysm and virus infection: a potential causative role for cytomegalovirus infection? J Med Virol. 2021;93(8):5017-5024.
[18] YUAN Z, LU Y, WEI J, et al. Abdominal aortic aneurysm: roles of inflammatory cells. Front Immunol. 2021;11:609161.
[19] QIAN G, ADEYANJU O, OLAJUYIN A, et al. Abdominal aortic aneurysm formation with a focus on vascular smooth muscle cells. Life (Basel). 2022; 12(2):191.
[20] MAZUREK R, DAVE JM, CHANDRAN RR, et al. Vascular cells in blood vessel wall development and disease. Adv Pharmacol. 2017;78:323-350.
[21] QUINTANA RA, TAYLOR WR. Cellular mechanisms of aortic aneurysm formation. Circ Res. 2019;124(4):607-618.
[22] PAN L, BAI P, WENG X, et al. Legumain is an endogenous modulator of integrin αvβ3 triggering vascular degeneration, dissection, and rupture. Circulation. 2022;145(9):659-674.
[23] KHANAFER K, GHOSH A, VAFAI K. Correlation between MMP and TIMP levels and elastic moduli of ascending thoracic aortic aneurysms. Cardiovasc Revasc Med. 2019;20(4):324-327.
[24] KOULLIAS GJ, RAVICHANDRAN P, KORKOLIS DP, et al. Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections. Ann Thorac Surg. 2004;78(6): 2106-2111.
[25] FRISMANTIENE A, PHILIPPOVA M, ERNE P, et al. Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity. Cell Signal. 2018;52:48-64.
[26] ALLEN CL, BAYRAKTUTAN U. Differential mechanisms of angiotensin II and PDGF-BB on migration and proliferation of coronary artery smooth muscle cells. J Mol Cell Cardiol. 2008;45(2):198-208.
[27] GREENBERG MVC, BOURC’HIS D. The diverse roles of DNA methylation in mammalian development and disease. Nat Rev Mol Cell Biol. 2019;20(10):590-607.
[28] SCHMITZ RJ, LEWIS ZA, GOLL MG. DNA methylation: shared and divergent features across eukaryotes. Trends Genet. 2019;35(11):818-827.
[29] CHEN LL, LIN HP, ZHOU WJ, et al. SNIP1 recruits TET2 to regulate c-MYC target genes and cellular DNA damage response. Cell Rep. 2018;25(6): 1485-1500.e4.
[30] TOGHILL BJ, SARATZIS A, FREEMAN PJ, et al. SMYD2 promoter DNA methylation is associated with abdominal aortic aneurysm (AAA) and SMYD2 expression in vascular smooth muscle cells. Clin Epigenetics. 2018;10:29.
[31] LINO CARDENAS CL, KESSINGER CW, MACDONALD C, et al. Inhibition of the methyltranferase EZH2 improves aortic performance in experimental thoracic aortic aneurysm. JCI Insight. 2018;3(5):e97493.
[32] ZHONG L, HE X, SI X, et al. SM22α (smooth muscle 22α) Prevents aortic aneurysm formation by inhibiting smooth muscle cell phenotypic switching through suppressing reactive oxygen species/NF-κB (nuclear factor-κB). Arterioscler Thromb Vasc Biol. 2019;39(1):e10-e25.
[33] VAN DEN BOSSCHE J, NEELE AE, HOEKSEMA MA, et al. Macrophage polarization: theepigenetic point of view. Curr Opin Lipidol. 2014;25(5): 367-373.
[34] STERNER DE, BERGER SL. Acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev. 2000;64(2):435-459.
[35] GREER EL, SHI Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet. 2012;13(5):343-357.
[36] PONS D, JUKEMA JW. Epigenetic histone acetylation modifiers in vascular remodelling - new targets for therapy in cardiovascular disease. Neth Heart J. 2008;16(1):30-32.
[37] GALÁN M, VARONA S, ORRIOLS M, et al. Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors. Dis Model Mech. 2016;9(5):541-552.
[38] GOMEZ D, COYET A, OLLIVIER V, et al. Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms. Cardiovasc Res. 2011;89(2):446-456.
[39] GOMEZ D, KESSLER K, MICHEL JB, et al. Modifications of chromatin dynamics control Smad2 pathway activation in aneurysmal smooth muscle cells. Circ Res. 2013;113(7):881-890.
[40] LINO CARDENAS CL, KESSINGER CW, CHENG Y, et al. An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm. Nat Commun. 2018;9(1):1009.
[41] KUMAR S, BOON RA, MAEGDEFESSEL L, et al. Role of noncoding RNAs in the pathogenesis of abdominal aortic aneurysm. Circ Res. 2019;124(4):619-630.
[42] WU ZY, TRENNER M, BOON RA, et al. Long noncoding RNAs in key cellular processes involved in aortic aneurysms. Atherosclerosis. 2020;292:112-118.
[43] KALAYINIA S, ARJMAND F, MALEKI M, et al. MicroRNAs: roles in cardiovascular development and disease. Cardiovasc Pathol. 2021;50: 107296.
[44] LI Y, MAEGDEFESSEL L. Non-coding RNA contribution to thoracic and abdominal aortic aneurysm disease development and progression. Front Physiol. 2017;8:429.
[45] VISHNOI A, RANI S. MiRNA biogenesis and regulation of diseases: an overview. Methods Mol Biol. 2017;1509:1-10.
[46] MANGUM KD, FARBER MA. Genetic and epigenetic regulation of abdominal aortic aneurysms. Clin Genet. 2020;97(6):815-826.
[47] ADAM M, RAAZ U, SPIN JM, et al. MicroRNAs in abdominal aortic aneurysm. Curr Vasc Pharmacol. 2015;13(3):280-290.
[48] SI X, CHEN Q, ZHANG J, et al. MicroRNA-23b prevents aortic aneurysm formation by inhibiting smooth muscle cell phenotypic switching via FoxO4 suppression. Life Sci. 2022;288:119092.
[49] SHI X, MA W, PAN Y, et al. MiR-126-5p promotes contractile switching of aortic smooth muscle cells by targeting VEPH1 and alleviates Ang II-induced abdominal aortic aneurysm in mice. Lab Invest. 2020;100(12):1564-1574.
[50] CAZZANELLI P, WUERTZ-KOZAK K. MicroRNAs in intervertebral disc degeneration, apoptosis, inflammation, and mechanobiology. Int J Mol Sci. 2020;21(10):3601.
[51] LI L, MA W, PAN S, et al. MiR-126a-5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS-4 expression. J Cell Mol Med. 2020;24(14):7896-7906.
[52] CHAN CYT, CHEUK BLY, CHENG SWK. Abdominal aortic aneurysm-associated MicroRNA-516a-5p regulates expressions of methylenetetrahydrofolate reductase, matrix metalloproteinase-2, and tissue inhibitor of matrix metalloproteinase-1 in human abdominal aortic vascular smooth muscle cells. Ann Vasc Surg. 2017;42:263-273.
[53] DING W, LIU Y, SU Z, et al. Emerging role of non-coding RNAs in aortic dissection. Biomolecules. 2022;12(10):1336.
[54] LIANG B, CHE J, ZHAO H, et al. MiR-195 promotes abdominal aortic aneurysm media remodeling by targeting Smad3. Cardiovasc Ther. 2017. doi: 10.1111/1755-5922.12286.
[55] YANG Z, ZHANG L, LIU Y, et al. Potency of miR-144-3p in promoting abdominal aortic aneurysm progression in mice correlates with apoptosis of smooth muscle cells. Vascul Pharmacol. 2022;142:106901.
[56] ZHANG H, WANG Y, BIAN X, et al. MicroRNA-194 acts as a suppressor during abdominal aortic aneurysm via inhibition of KDM3A-mediated BNIP3. Life Sci. 2021;277:119309.
[57] HAN ZL, WANG HQ, ZHANG TS, et al. Up-regulation of exosomal miR-106a may play a significant role in abdominal aortic aneurysm by inducing vascular smooth muscle cell apoptosis and targeting TIMP-2, an inhibitor of metallopeptidases that suppresses extracellular matrix degradation. Eur Rev Med Pharmacol Sci. 2020;24(15):8087-8095.
[58] ZHAO L, OUYANG Y, BAI Y, et al. miR-155-5p inhibits the viability of vascular smooth muscle cell via targeting FOS and ZIC3 to promoteb aneurysm formation. Eur J Pharmacol. 2019;853:145-152.
[59] CAO X, CAI Z, LIU J, et al. miRNA504 inhibits p53dependent vascular smooth muscle cell apoptosis and may prevent aneurysm formation. Mol Med Rep. 2017;16(3):2570-2578.
[60] CAI Z, HUANG J, YANG J, et al. LncRNA SENCR suppresses abdominal aortic aneurysm formation by inhibiting smooth muscle cells apoptosis and extracellular matrix degradation. Bosn J Basic Med Sci. 2021;21(3):323-330.
[61] WANG Y, ZHAI S, XING J, et al. LncRNA GAS5 promotes abdominal aortic aneurysm formation through regulating the miR-185-5p/ADCY7 axis. Anticancer Drugs. 2022;33(3):225-234.
[62] HUANG Y, REN L, LI J, et al. Long non-coding RNA PVT1/microRNA miR-3127-5p/NCK-associated protein 1-like axis participates in the pathogenesis of abdominal aortic aneurysm by regulating vascular smooth muscle cells. Bioengineered. 2021;12(2):12583-12596.
[63] ZHANG D, LU D, XU R, et al. Inhibition of XIST attenuates abdominal aortic aneurysm in mice by regulating apoptosis of vascular smooth muscle cells through miR-762/MAP2K4 axis. Microvasc Res. 2022;140: 104299.
[64] YANG B, WANG X, YING C, et al. Long noncoding RNA SNHG16 facilitates abdominal aortic aneurysm progression through the miR-106b-5p/STAT3 feedback loop. J Atheroscler Thromb. 2021;28(1):66-78.
[65] NIE H, ZHAO W, WANG S, et al. Based on bioinformatics analysis lncrna SNHG5 modulates the function of vascular smooth muscle cells through mir-205-5p/SMAD4 in abdominal aortic aneurysm. Immun Inflamm Dis. 2021;9(4):1306-1320.
[66] XIA Q, ZHANG L, YAN H, et al. LUCAT1 contributes to MYRF-dependent smooth muscle cell apoptosis and may facilitate aneurysm formation via the sequestration of miR-199a-5p. Cell Biol Int. 2020;44(3):755-763.
[67] LI H, ZHANG H, WANG G, et al. LncRNA LBX2-AS1 facilitates abdominal aortic aneurysm through miR-4685-5p/LBX2 feedback loop. Biomed Pharmacother. 2020;129:109904.
[68] ZHOU F, ZHENG Z, ZHA Z, et al. Nuclear paraspeckle assembly transcript 1 enhances hydrogen peroxide-induced human vascular smooth muscle cell injury by regulating miR-30d-5p/A disintegrin and metalloprotease 10. Circ J. 2022;86(6):1007-1018.
[69] GOLLEDGE J. Abdominal aortic aneurysm: update on pathogenesis and medical treatments. Nat Rev Cardiol. 2019;16(4):225-242.
[70] LEMAIRE SA, WANG X, WILKS JA, et al. Matrix metalloproteinases in ascending aortic aneurysms: bicuspid versus trileaflet aortic valves. J Surg Res. 2005;123(1): 40-48.
[71] GURUNG R, CHOONG AM, WOO CC, et al. Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm. Int J Mol Sci. 2020;21(17):6334. |