中国组织工程研究

中国组织工程研究 ›› 2023, Vol. 27 ›› Issue (19): 3070-3076.doi: 10.12307/2023.659

• 干细胞综述 stem cell review • 上一篇    

地黄类方药联合间充质干细胞治疗缺血性脑卒中的作用机制

魏智慧，刘飞祥，潘小龙，孙世标，张运克   

  1. 河南中医药大学，河南省郑州市   450000
  • 收稿日期:2022-08-01 接受日期:2022-09-24 出版日期:2023-07-08 发布日期:2022-11-28
  • 通讯作者: 张运克，博士，教授，主任医师，博士生导师，博士后合作导师，河南中医药大学，河南省郑州市 450000
  • 作者简介:魏智慧，女，1996年生，河南中医药大学在读硕士，河南省焦作市人，汉族，主要从事中医药防治神经系统疾病的研究。
  • 基金资助:
    国家自然科学基金(81974564)，项目负责人：张运克；国家自然科学基金(82104730)，项目负责人：刘飞祥；中原英
    才计划-科技创新领军人才项目(224200510027)，项目负责人：张运克

Mechanism of Rehmannia glutinosa combined with mesenchymal stem cells in treating ischemic stroke

Wei Zhihui, Liu Feixiang, Pan Xiaolong, Sun Shibiao, Zhang Yunke   

  1. Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China
  • Received:2022-08-01 Accepted:2022-09-24 Online:2023-07-08 Published:2022-11-28
  • Contact: Zhang Yunke, MD, Professor, Chief physician, Doctoral supervisor, Henan University of Chinese Medicine, Zhengzhou 450046, Henan Province, China
  • About author:Wei Zhihui, Master candidate, Henan University of Chinese Medicine, Zhengzhou 450046, Henan Province, China
  • Supported by:
    the National Natural Science Foundation of China, Nos. 81974564 (to ZYK) and 82104730 (to LFX); Central Plains Talent Plan-Science and Technology Innovation Leading Talents Project, No. 224200510027 (to ZYK)

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摘要：


文题释义：

间充质干细胞：是重要的成体干细胞，具有组织修复、免疫调节、自我更新和多向分化潜能，可作为理想的种子细胞用于衰老和缺血性脑卒中引起的组织器官损伤修复。
地黄类方药：主要包括地黄及地黄复方，具有补血滋阴、益精填髓的功效，是补肾的代表方药，在治疗缺血性脑卒中及抗衰老方面具有独特的优势。

背景：地黄类方药具有抑制氧化应激反应、抑制细胞凋亡、抑制神经炎症、促进血管神经新生、抗衰老的作用，在治疗缺血性脑卒中方面具有独特的优势。以间充质干细胞为载体与地黄类方药联合，可以更好地发挥其治疗缺血性脑卒中的作用。
目的：对地黄类方药联合间充质干细胞治疗缺血性脑卒中的作用机制作一综述。
方法：检索中国知网和PubMed数据库2012-2022年关于地黄类方药联合间充质干细胞治疗缺血性脑卒中的文献，以“地黄、间充质干细胞、缺血性脑卒中”为中文检索词，以“Rehmannia，mesenchymal stem cells (MSCs)，ischemic stroke”为英文检索词，最终共纳入86篇文献进行分析。
结果与结论：①文章梳理了间充质干细胞治疗缺血性脑卒中的作用机制，主要包括促进细胞迁移、促进细胞分化、免疫调节和抑制细胞凋亡等；②文章梳理了地黄类方药治疗缺血性脑卒中的作用机制，主要包括抑制氧化应激、抑制神经炎症、抑制细胞凋亡、促进神经血管新生和抗衰老等作用；③文章总结了地黄类方药可以激发间充质干细胞的活力，促进间充质干细胞的增殖，诱导间充质干细胞向神经样细胞方向分化，提高间充质干细胞在体内的成活率，从而达到协同治疗缺血性脑卒中的目的。④文章总结了地黄类方药联合间充质干细胞治疗缺血性脑卒中的相关作用机制，主要包括抑制氧化应激反应、抑制细胞凋亡、抗衰老、促进血管新生和促进神经重塑等，以期为今后缺血性脑卒中的新的治疗方法提供理论参考。
https://orcid.org/0000-0003-1500-1535 (张运克) 
中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 干细胞, 地黄, 复方, 间充质干细胞, 缺血性脑卒中, 抗衰老, 血管新生, 神经重塑, 综述

Abstract: BACKGROUND: Rehmannia glutinosa has the effects of inhibiting oxidative stress, inhibiting apoptosis, inhibiting nerve inflammation, promoting angiogenesis and anti-aging, and has unique advantages in the treatment of ischemic stroke. The combination of Rehmannia glutinosa with mesenchymal stem cells as a carrier can play a better role in the treatment of ischemic stroke.  
OBJECTIVE: To review the research progress of Rehmannia glutinosa combined with mesenchymal stem cells in the treatment of ischemic stroke.
METHODS: We searched CNKI and PubMed for the literature on the treatment of senile ischemic stroke with Rehmannia glutinosa combined with mesenchymal stem cells from 2012 to 2022. The keywords were “Rehmannia, mesenchymal stem cells (MSCs), ischemic stroke” in Chinese and English, respectively. Finally, 86 articles were included for further review.  
RESULTS AND CONCLUSION: (1) The mechanisms of mesenchymal stem cells in the treatment of ischemic stroke were reviewed, including the promotion of cell migration and differentiation, immunomodulation, and inhibition of apoptosis. (2) The mechanisms of Rehmannia glutinosa in treating ischemic stroke were summarized, including inhibition of oxidative stress, inhibition of nerve inflammation, inhibition of apoptosis, promotion of neuroangiogenesis, and anti-aging. (3) Rehmannia glutinosa could stimulate the vitality of mesenchymal stem cells, promote the proliferation of mesenchymal stem cells, induce the differentiation of mesenchymal stem cells into neuron-like cells, and improve the survival rate of mesenchymal stem cells in vivo, so as to achieve the goal of synergistic treatment of ischemic stroke. (4) The mechanism of Rehmannia glutinosa combined with mesenchymal stem cells in the treatment of ischemic stroke was summarized, including inhibition of oxidative stress, inhibition of apoptosis, anti-aging, promotion of angiogenesis and nerve remodeling, thereby providing theoretical reference for the new treatment of ischemic stroke in the future.

Key words: stem cell, Rehmannia glutinosa, compound, mesenchymal stem cell, ischemic stroke, anti-aging, angiogenesis, nerve remodeling, review

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