中国组织工程研究 ›› 2023, Vol. 27 ›› Issue (29): 4696-4703.doi: 10.12307/2023.480
• 骨与关节综述 bone and joint review • 上一篇 下一篇
谌 超,王学楠,展恩雨,吕正品,张 帆
收稿日期:
2022-05-23
接受日期:
2022-08-13
出版日期:
2023-10-18
发布日期:
2022-12-02
通讯作者:
张帆,博士,副教授,昆明医科大学第一附属医院骨科,云南省昆明市 650032
作者简介:
谌超,男,1998年生,昆明医科大学在读硕士,主要从事脊柱外科方面的研究。
基金资助:
Chen Chao, Wang Xuenan, Zhan Enyu, Lyu Zhengpin, Zhang Fan
Received:
2022-05-23
Accepted:
2022-08-13
Online:
2023-10-18
Published:
2022-12-02
Contact:
Zhang Fan, MD, Associate professor, Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
About author:
Chen Chao, Master candidate, Department of Orthopedics, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
Supported by:
摘要:
文题释义:
昼夜节律:是每天可预测的生理、行为和环境变化,持续时间约为24 h,其从宏观方面(例如睡眠-觉醒循环)到微观现象(例如生物分子的节律性丰度)存在于每个生物尺度上。在哺乳动物中,日常昼夜节律变化由位于视交叉上核中的下丘脑主时钟和外周组织中的时钟振荡介导,它们分别与光和进食时间同步。中图分类号:
谌 超, 王学楠, 展恩雨, 吕正品, 张 帆. 昼夜节律与自噬相互调控的机制[J]. 中国组织工程研究, 2023, 27(29): 4696-4703.
Chen Chao, Wang Xuenan, Zhan Enyu, Lyu Zhengpin, Zhang Fan. Mechanism underlying the mutual regulation between circadian rhythm and autophagy[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(29): 4696-4703.
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1.1 资料来源
1.1.1 检索人及检索时间 第一作者于2022年2-5月进行文献检索收集。
1.1.2 检索文献时限 检索1973年3月至2022年5月发表的相关文献。
1.1.3 检索数据库 PubMed 数据库、Web of Science、中国知网、万方数据库。
1.1.4 检索词 以“circadian rhythm,autophagy,molecular circadian clock,regulation,gene”为英文主题词,以“昼夜节律,自噬,分子生物钟,调控,基因”为中文主题词。
1.1.5 检索文献类型 研究原著、综述等。
1.1.6 手工检索情况 手动补充相关调控机制的验证和内容解释说明文献及2000年之前重要研究节点的文献。
1.1.7 检索策略 以Web of Science数据库为例,文献检索式如图1所示。检索结果通过Endnote x9软件进行统计。
1.2 资料筛选标准
1.2.1 纳入标准 ①与上述检索词相关的研究;②文献类型为正式发表的研究型论著或综述。
1.2.2 排除标准 ①重复、低质量的文献;②会议记录、通信、评论等类型的文献;③质量不高、证据等级低的文献;④非中、英文文献;⑤无法获得全文的文献。
1.3 文献检索流程 通过纳入和排除标准最终纳入107篇文献,见图2。
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文题释义:
昼夜节律:是每天可预测的生理、行为和环境变化,持续时间约为24 h,其从宏观方面(例如睡眠-觉醒循环)到微观现象(例如生物分子的节律性丰度)存在于每个生物尺度上。在哺乳动物中,日常昼夜节律变化由位于视交叉上核中的下丘脑主时钟和外周组织中的时钟振荡介导,它们分别与光和进食时间同步。随着研究的逐渐深入,越来越多的证据支持自噬与昼夜节律相关的假设。本综述从参与昼夜节律调控自噬的相关基因、转录因子和通路、昼夜节律生物钟核心成分如何调控自噬、自噬如何调控昼夜节律等3个方面总结并讨论了目前自噬与昼夜节律之间的相互作用和调控机制。此外,还介绍了影响自噬和昼夜节律的分子及其药物,为未来进行自噬与昼夜节律的相关研究提供了方向和见解,并为其相关疾病的临床治疗提供新的见解,对于阐明人类昼夜节律性自噬在人类健康和疾病中的功能意义与治疗潜力具有重大作用。
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