中国组织工程研究 ›› 2023, Vol. 27 ›› Issue (15): 2385-2394.doi: 10.12307/2023.361
• 干细胞综述 stem cell review • 上一篇 下一篇
应春苗1,麻玉成1,樊飞燕1,高 晨1,王绍娜1,杨 星1,张运克1,2
收稿日期:
2022-05-05
接受日期:
2022-06-25
出版日期:
2023-05-28
发布日期:
2022-10-18
通讯作者:
张运克,博士,2007年从中国中医科学院博士后流动站出站,教授,主任医师,博士生导师,博士后合作导师,河南中医药大学,河南省郑州市 450046;河南中医药大学第一附属医院,河南省郑州市 450000
作者简介:
应春苗,女,1996年生,河南省漯河市人,汉族,河南中医药大学在读硕士,主要从事中医药防治神经内科疾病的研究。
基金资助:
Ying Chunmiao1, Ma Yucheng1, Fan Feiyan1, Gao Chen1, Wang Shaona1, Yang Xing1, Zhang Yunke1, 2
Received:
2022-05-05
Accepted:
2022-06-25
Online:
2023-05-28
Published:
2022-10-18
Contact:
Zhang Yunke, MD, Professor, Chief physician, Doctoral supervisor, Post-doctoral cooperative supervisor, Henan University of Chinese Medicine, Zhengzhou 450046, Henan Province, China; First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China
About author:
Ying Chunmiao, Master candidate, Henan University of Chinese Medicine, Zhengzhou 450046, Henan Province, China
Supported by:
摘要:
文题释义:
神经干细胞:是一种自我更新能力强且具多向分化潜能的神经祖细胞,可以分化为多种细胞类型,例如神经元、星形胶质细胞和少突胶质细胞,具有营养神经、促进神经再生和免疫调节作用。
阿尔茨海默病:是一种神经退行性病变,患者常出现近期记忆障碍、理解、计划、解决问题等能力下降,严重者导致死亡,其具体病因迄今未明,但年龄是公认的危险因素。阿尔茨海默病的病理机制尚未确定,其病理特征是大脑皮质和海马区域的神经元大量死亡及神经元变性。
背景:神经干细胞具有修复和代替受损神经细胞、刺激神经发生、重建细胞环路、抑制细胞凋亡的作用,治疗阿尔茨海默病的效果良好,中药在调控神经干细胞增殖、分化及提高神经细胞活力与细胞生存率等方面亦存在显著疗效。
目的:综述中药调控神经干细胞治疗阿尔茨海默病的机制,以期为阿尔茨海默病的新药研究及治疗提供参考。
方法:检索万方、CNKI、PubMed、Web of Science等数据库2010-2022年期间关于中药调控神经干细胞治疗阿尔茨海默病的文献,以“神经干细胞,中药,阿尔茨海默病”为中文检索词,以“neural stem cells(NSCs),Alzheimer’s disease,Traditional Chinese medicine (TCM)”为英文检索词。排除陈旧及重复的观点,将检索到的文献进行分析整理,共纳入121篇文献进行分析。
结果与结论:①梳理了神经干细胞、阿尔茨海默病的定义及发病机制;②总结了中药调控神经干细胞治疗阿尔茨海默病的作用机制,主要包括促进神经干细胞增殖、改善脑内微环境、抑制神经细胞凋亡、诱导神经干细胞向神经元分化、改善神经炎症、调控血管神经单元;③通过现有的研究总结了中药调控神经干细胞治疗阿尔茨海默病的相关因子及信号通路,如Nestin蛋白、微管相关蛋白、脑源性神经营养因子、血管内皮生长因子及Notch信号通路、P13k/Akt信号通路、脑源性神经营养因子/TrkB信号通路和Wnt/β-catenin信号通路等,为今后阿尔茨海默病特效药物及新治疗方法的研究提供相关参考。
https://orcid.org/0000-0003-1500-1535 (张运克)
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
中图分类号:
应春苗, 麻玉成, 樊飞燕, 高 晨, 王绍娜, 杨 星, 张运克. 中药调控神经干细胞治疗阿尔茨海默病的作用机制[J]. 中国组织工程研究, 2023, 27(15): 2385-2394.
Ying Chunmiao, Ma Yucheng, Fan Feiyan, Gao Chen, Wang Shaona, Yang Xing, Zhang Yunke. Action mechanism of traditional Chinese medicine to regulate neural stem cells in treatment of Alzheimer’s disease[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(15): 2385-2394.
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1.1 资料来源 第一作者在2022年1月进行检索。选择中国知网、万方数据库、Web of Science、PubMed数据库, 以“neural stem cells,Alzheimer disease,traditional Chinese medicine”为英文关键词,以“神经干细胞,阿尔茨海默病,中药”为中文关键词,检索2010-2022年期间的文献,包括论著、综述、实验研究、技术与方法、述评、病例报告等。初步检索英文文献1 166篇,中文文献198篇。以PubMed数据库为例,检索策略见图2。
1.2 文献筛选标准 去除重复文献及与研究主题相关性差的文献,选择与研究目的、内容关系密切的文献。
1.3 质量评估及数据的提取 计算机初检得到中文文献198篇,英文文献1 166篇,经资料收集者互相评估纳入文献的有效性和适用性,通过阅读文题和摘要进行初步筛选;排除中英文文献重复性研究,以及内容不相关的文献,最后纳入中英文文献共121篇进行综述。文献检索流程见图3。
文题释义:#br# 神经干细胞:是一种自我更新能力强且具多向分化潜能的神经祖细胞,可以分化为多种细胞类型,例如神经元、星形胶质细胞和少突胶质细胞,具有营养神经、促进神经再生和免疫调节作用。#br# 阿尔茨海默病:是一种神经退行性病变,患者常出现近期记忆障碍、理解、计划、解决问题等能力下降,严重者导致死亡,其具体病因迄今未明,但年龄是公认的危险因素。阿尔茨海默病的病理机制尚未确定,其病理特征是大脑皮质和海马区域的神经元大量死亡及神经元变性。
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
阿尔茨海默病作为一种神经退行性疾病,给全球卫生经济带来沉重负担。近几十年来,干细胞疗法作为一种新的治疗方法在神经系统疾病方向已受到广泛认可,神经干细胞在治疗阿尔茨海默病、帕金森病、亨廷顿病等神经退行性疾病中具有较为良好的效果,传统中医药在阿尔茨海默病治疗中展现出其独特的优势。现代研究发现,中药在神经干细胞增殖、存活及分化过程中具有积极影响,在治疗阿尔茨海默病方面起到协同作用,在未来,充分发掘、研究中药与神经干细胞治疗阿尔茨海默病的作用机制及相关靶点,为新药开发及新治疗方法研究提供思路与参考。
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
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