中国组织工程研究

中国组织工程研究 ›› 2022, Vol. 26 ›› Issue (18): 2945-2951.doi: 10.12307/2022.707

• 骨与关节综述 bone and joint review • 上一篇    下一篇

白细胞介素6参与成骨及骨修复的一系列反应过程

王  景1，王万宇骥2，张  怡3，马亚萍1，王  信1   

  1. 1遵义医科大学附属医院骨科，贵州省遵义市   563003；2遵义医科大学，贵州省遵义市   563000；3遵义医科大学公共卫生学院，贵州省遵义市   563000
  • 收稿日期:2021-10-18 接受日期:2021-11-05 出版日期:2022-06-28 发布日期:2022-01-30
  • 通讯作者: 王信，博士，主任医师，博士生导师，遵义医科大学附属医院骨科，贵州省遵义市 563003 马亚萍，硕士，实验师，遵义医科大学附属医院，贵州省遵义市 563000
  • 作者简介:王景，男，1995年生，安徽省安庆市人，汉族，遵义医科大学在读硕士，主要从事骨缺损早期愈合的基础研究。 王万宇骥，2002年生，重庆市人，汉族，遵义医科大学2020级临床医学系南山班在读本科。
  • 基金资助:
    国家自然科学基金(31960209，31760266)，项目负责人：王信；贵州省科技厅基础研究计划(黔科合基础[2020]1Y093)，项目负责人：王信；遵义医科大学附属医院博士启动基金(2017-01)，项目负责人：王信；遵义市联合基金项目[遵市科合HZ字(2021)40号] 项目负责人：马亚萍

Interleukin 6 involved in a series of reaction processes of osteogenesis and bone repair

Wang Jing1, Wang Wanyuji2, Zhang Yi3, Ma Yaping1, Wang Xin1   

  1. 1Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China; 2Zunyi Medical University, Zunyi 563000, Guizhou Province, China; 3School of Public Health, Zunyi Medical University, Zunyi 563000, Guizhou Province, China
  • Received:2021-10-18 Accepted:2021-11-05 Online:2022-06-28 Published:2022-01-30
  • Contact: Wang Xin, MD, Chief physician, Doctoral supervisor, Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China Ma Yaping, Master, Experimentalist, Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China
  • About author:Wang Jing, Master candidate, Department of Orthopedics, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou Province, China Wang Wanyuji, Zunyi Medical University, Zunyi 563000, Guizhou Province, China Wang Jing and Wang Wanyuji contributed equally to this article.
  • Supported by:
    National Natural Science Foundation of China, No. 31960209, 31760266) (to WX); Basic Research Program of Guizhou Science and Technology Department, No. [2020]1Y093 (to WX); Doctor Starting Fund of Affiliated Hospital of Zunyi Medical University, No. 2017-01 (to WX); Zunyi Joint Fund Project, No. Zunyi Kehe HZ Zi (2021) 40 (to MYP)

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摘要：

文题释义：
白细胞介素6：体内广泛存在的一类细胞因子，诱导单核细胞分化，抑制细胞凋亡，在骨修复过程各种细胞产生并在血管修复中发挥作用。
成骨：骨缺损发生后，机体中的各种细胞反应和生物效应将骨组织修复的一系列反应过程。

背景：大节段骨缺损的愈合一直是临床难题，虽然已经发现多种促进成骨的物质，但炎症因子对骨愈合影响的研究还需要继续深入，特别是其在骨愈合早期影响成骨的重要因素还需要继续研究。
目的：综述目前已知相关文献，总结白细胞介素6与骨代谢之间的关系，了解白细胞介素6在成骨中的作用机制，为新的成骨方案提供理论参考。
方法：由第一作者于2021年7-8月进行检索，检索1990年1月至2021年7月PubMed数据库及1979年1月至2021年7月CNKI数据库相关文献，英文检索词为“Interleukin 6” or“bone metabolism”or“osteoblast”or“osteoclast”or“bone regeneration”or “Mesenchymal stem cells”or“Vascularization”，中文检索词为“白细胞介素6”and“骨再生”，“白细胞介素6”and“成骨细胞”，“白细胞介素6”and“破骨细胞”，“白细胞介素6”and“骨代谢”。初检得到中英文文章903篇，按纳入排除标准共纳入88篇文献进行综述分析。
结果与结论：白细胞介素6作为体内作用十分广泛的细胞因子，在成骨的各个阶段发挥着重要的作用。①研究发现白细胞介素6对于骨修复阶段的各种细胞(如间充质干细胞、成骨细胞、破骨细胞)以及骨缺损处的血管生成都有着重要的作用。②白细胞介素6在体内与多种成骨因素串扰，在庞大的骨修复网络中发挥效应。③血凝块作为促进早期骨愈合的重要因素，白细胞介素6除了可以调控血凝块的生成，还可以通过调节γ纤维蛋白影响血凝块的结构；而血凝块的结构对成骨早期有着重要影响，故白细胞介素6可以通过调节血凝块的结构进而影响骨愈合早期阶段。④该文深入综述白细胞介素6影响成骨的具体机制，有望进一步深入了解骨再生愈合，为成骨提供新的治疗策略和治疗方案。

https://orcid.org/0000-0001-5015-3396(王信)；https://orcid.org/0000-0001-6745-5411(王景) 

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

关键词: 白细胞介素6, 成骨, 成骨细胞, 破骨细胞, 血凝块, 综述

Abstract: BACKGROUND: The healing of large segmental bone defects has been a clinical challenge, although several substances that promote osteogenesis have been identified. However, further studies are needed on the effects of inflammatory factors on bone healing, especially on the important factors affecting osteogenesis in the early stage of bone healing.  
OBJECTIVE: To summarize the relationship between interleukin-6 and bone metabolism, understand the mechanism of interleukin 6 in osteogenesis, and provide theoretical reference for new osteogenesis programs.
METHODS:  A search was conducted by the first author between July and August 2021 to retrieve relevant articles on PubMed database from January 1990 to July 2021 and CNKI database from January 1979 to July 2021. The English key words were “interleukin 6” or “bone metabolism” or “osteoblast” or “osteoclast” or “bone regeneration” or “mesenchymal stem cells” or “vascularization”. The Chinese key words were “interleukin 6” and “bone regeneration”, “interleukin 6” and “osteoblast”, “interleukin 6” and “osteoclast”, “interleukin 6” and “bone metabolism”. A total of 903 Chinese and English articles were obtained and 88 articles were included for review and analysis according to inclusion and exclusion criteria.  
RESULTS AND CONCLUSION: Interleukin 6, as a cytokine with a wide range of functions in vivo, also plays an important role in all stages of osteogenesis. (1) Interleukin 6 has been found to play an important role in various bone repair cells (such as mesenchymal stem cells, osteoblasts and osteoclasts) as well as in angiogenesis of bone defects. (2) Interleukin 6 interacts with a variety of osteogenic factors in vivo and exerts an effect in a vast network of bone repair. (3) Blood clots as an important factor can promote early bone healing; interleukin 6 can not only regulate the formation of blood clots, but also affect the structure of blood clots by regulating γ fibrin strips. The structure of blood clot has an important influence on the early stage of osteogenesis, so interleukin-6 can affect the early stage of bone healing by regulating the structure of blood clot. (4) In this paper, the specific mechanism of interleukin 6 affecting osteogenesis is reviewed, which is expected to further understand bone regeneration and healing, and provide new therapeutic strategies and protocols for osteogenesis.

Key words: interleukin 6, osteogenesis, osteoblasts, osteoclasts, blood clot, review

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