中国组织工程研究 ›› 2022, Vol. 26 ›› Issue (3): 446-455.doi: 10.12307/2022.074
• 骨与关节综述 bone and joint review • 上一篇 下一篇
关 健1,2,贾燕飞2,张葆鑫2,赵国中1,2
收稿日期:
2021-02-25
修回日期:
2021-02-27
接受日期:
2021-04-17
出版日期:
2022-01-28
发布日期:
2021-10-29
通讯作者:
贾燕飞,主任医师,内蒙古医科大学第二附属医院,内蒙古自治区呼和浩特市 010030
作者简介:
关健,男,1993年生,内蒙古自治区通辽市人,蒙古族,内蒙古医科大学在读硕士,医师,主要从事骨科学方面的研究。
Guan Jian1, 2, Jia Yanfei2, Zhang Baoxin 2, Zhao Guozhong1, 2
Received:
2021-02-25
Revised:
2021-02-27
Accepted:
2021-04-17
Online:
2022-01-28
Published:
2021-10-29
Contact:
Jia Yanfei, Chief physician, Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China
About author:
Guan Jian, Master candidate, Physician, Inner Mongolia Medical University, Hohhot 010110, Inner Mongolia Autonomous Region, China; Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China
摘要:
文题释义:
4D生物打印:4D打印本质上是一种三维打印技术,其中包含的第四维被称为“时间”,这项技术需要具有随时间变化的多材料打印能力,或者需要一种可以从一种形状改变为另一种形状的定制材料系统。对于 4D 打印一个较为全面的定义是:一个三维印刷结构被暴露于预定刺激下(如温度、水、光、pH值等),其功能、形状、性能可随时间发生变化。因此,与 3D 打印技术相比,4D 打印最大的突破在于其随时间变化的能力,而4D生物打印则是打印材料及打印产品具有生物相容性。
智能材料:泛指将传感元件、驱动元件以及有关的信号处理和控制电路集成在材料结构中,通过机、热、光、化、电、磁等刺激和控制,使其不仅具有承受载荷的能力,而且具有识别、分析、处理及控制等多种功能,能进行自诊断、自适应、自学习及自修复。
背景:随着科技的不断发展3D生物打印已经成为组织工程学的重点研究领域,然而目前仍存在一些局限性无法解决。4D生物打印是最新兴起的一种技术,它成为了组织工程下一代的主要解决手段。
目的:根据不同形状转变原理而分别介绍4D生物打印的材料和方式,探讨4D生物打印在组织工程中的应用以及目前面临的挑战。
方法:以“4D bioprinting,4D biofabriation,printing,smart materials,smart scaffold,shape memory polymers,tissue engineering”或“4D生物打印,4D生物制造,打印,智能材料,智能支架,形状记忆聚合物,组织工程”等作为检索词,应用互联网在CNKI、PubMed、SCIE数据库检索2016-01-01/2021-01-01发表的相关文献共127篇,经过第一作者筛除并追加收录优质参考文献,共纳入106篇文章进行综述分析。
结果与结论:①4D生物打印是最新兴起的一种技术,它将时间的概念和3D生物打印相结合作为第四维度,4D生物打印能够制造复杂的具有功能性的结构;②它可以通过使用智能材料制作动态的三维生物结构,这些结构可以在各种刺激下改变形状;③印刷细胞结构的功能转变和成熟也被认为是4D生物打印其中的一种形式;④该技术为组织工程提供了前所未有的潜力,虽然该技术在生物医学领域备受瞩目,但由于其尚处于兴起阶段,若想实现临床应用还需要更多的研究和发展。
https://orcid.org/0000-0001-8034-5954 (关健)
中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱;骨折;内固定;数字化骨科;组织工程
中图分类号:
关 健, 贾燕飞, 张葆鑫, 赵国中. 4D生物打印在组织工程的应用[J]. 中国组织工程研究, 2022, 26(3): 446-455.
Guan Jian, Jia Yanfei, Zhang Baoxin , Zhao Guozhong. Application of 4D bioprinting in tissue engineering[J]. Chinese Journal of Tissue Engineering Research, 2022, 26(3): 446-455.
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1.3 质量评估 通过该检索式检索出相关文献共126篇,根据文章内容初步筛选56篇,追踪收录优质参考文献50篇,最终收录105篇英文文献和1篇中文文献,见图2。
文题释义:#br# 4D生物打印:4D打印本质上是一种三维打印技术,其中包含的第四维被称为“时间”,这项技术需要具有随时间变化的多材料打印能力,或者需要一种可以从一种形状改变为另一种形状的定制材料系统。对于 4D 打印一个较为全面的定义是:一个三维印刷结构被暴露于预定刺激下(如温度、水、光、pH值等),其功能、形状、性能可随时间发生变化。因此,与 3D 打印技术相比,4D 打印最大的突破在于其随时间变化的能力,而4D生物打印则是打印材料及打印产品具有生物相容性。#br# 智能材料:泛指将传感元件、驱动元件以及有关的信号处理和控制电路集成在材料结构中,通过机、热、光、化、电、磁等刺激和控制,使其不仅具有承受载荷的能力,而且具有识别、分析、处理及控制等多种功能,能进行自诊断、自适应、自学习及自修复。
通常应用形状记忆材料进行打印时,将打印模型放在在适当的条件下,使其处于亚稳态的临时形状。随后在施加外界刺激过程中逐步恢复,当施加足够的变换刺激时,临时变形的结构将变换成所需的形状,这种形状恢复特性对于治疗小骨缺损植入方式有良好的效果。
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