中国组织工程研究

中国组织工程研究 ›› 2021, Vol. 25 ›› Issue (32): 5210-5214.doi: 10.12307/2021.226

• 组织构建综述 tissue construction review • 上一篇    下一篇

股骨头坏死动物模型评价方法的优缺点及展望

楼鹏强1，魏  巍1，侯德才2   

  1. 1辽宁中医药大学，辽宁省沈阳市    110032；2辽宁中医药大学附属医院骨伤二科，辽宁省沈阳市    110032

  • 收稿日期:2020-09-24 修回日期:2020-09-28 接受日期:2020-10-30 出版日期:2021-11-18 发布日期:2021-07-26
  • 通讯作者: 侯德才，博士，主任医师，辽宁中医药大学附属医院骨伤二科，辽宁省沈阳市 110032
  • 作者简介:楼鹏强，男，1996年生，浙江省义乌市人，汉族，辽宁中医药大学在读硕士，主要从事骨坏死与骨关节炎方面的研究。
  • 基金资助:
    沈阳市科技局科技人才应用技术研究计划项目(18014405)，项目负责人：侯德才

Evaluation methods of animal models of femoral head necrosis: merits and demerits

Lou Pengqiang1, Wei Wei1, Hou Decai2   

  1. 1Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China; 2Department of Orthopedics and Traumatology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
  • Received:2020-09-24 Revised:2020-09-28 Accepted:2020-10-30 Online:2021-11-18 Published:2021-07-26
  • Contact: Hou Decai, MD, Chief physician, Department of Orthopedics and Traumatology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
  • About author:Lou Pengqiang, Master candidate, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
  • Supported by:
    the Technology Talent Project for Applied Technology Research of Shenyang Municipal Science and Technology Bureau, No. 18014405 (to HDC)

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摘要：

文题释义：
动物模型：是指在医学实验研究中建立的能高度模拟人病理生理过程的动物模型，是人类探索疾病发展规律和研究医学难题的重要工具和媒介。
股骨头坏死：在各种病因的多重因素的共同作用下，使股骨头发生部分或完全性缺血，导致骨细胞、骨髓造血细胞及脂肪细胞坏死，而坏死骨骨小梁在应力作用下发生骨折，同时坏死骨组织不断修复。在致病因素未消除的情况下，骨小梁损伤和修复过程不断进行，最终导致股骨头坏死，出现功能障碍。
背景：股骨头坏死发病机制仍需要进一步研究，因此需要建立一个能够高度模拟人类股骨头坏死的动物模型，而如何正确评价股骨头坏死动物模型，是建立股骨头坏死动物模型的前提条件。
目的：归纳总结近几年国内外对股骨头坏死动物模型的评价方法，综述各评价方法的优缺点，并探索新的评价方法，为动物模型的建立提供参考。
方法：以“股骨头坏死，动物模型，评价方法”为检索词检索CNKI 中国知网、万方、维普数据库，以“osteonecrosis of femoral head，femoral head necrosis，animal model，evaluation methods”为检索词检索PubMed、Web of Science及Medline数据库，检索2010年1月至2020年9月发表关于股骨头坏死动物模型评价方法的文献。
结果与结论：①根据纳入标准通过阅读文献进行初步筛选，共获得51篇文章进行综述，其中中文文献33篇，英文文献18篇；②近年来，随着影像技术的发展和新技术的引入，股骨头坏死动物模型评估方法的选择增多，而选择合理的评价方式能减少建立动物模型过程中的工作量，并为后续研究提供参考，因此需要继续完善和改进。

https://orcid.org/0000-0001-6743-5453 (楼鹏强) 
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


关键词: 股骨头坏死, 动物模型, 评价方法, 影像技术, 综述

Abstract: BACKGROUND: The pathogenesis of osteonecrosis of the femoral head (ONFH) still needs to be further studied, so it is necessary to establish an animal model that can highly simulate ONFH in humans. However, how to correctly evaluate the animal model of ONFH is a prerequisite for establishing the animal model of ONFH.
OBJECTIVE: To summarize the evaluation methods of ONFH animal models worldwide in recent years, review the advantages and disadvantages of each evaluation method, explore new evaluation methods, and provide reference for the establishment of animal models.
METHODS: Literatures related to the evaluation methods of ONFH animal models published from January 2010 to September 2020 were retrieved in CNKI, WanFang, VIP, PubMed, Web of Science and Medline with the terms “osteonecrosis of femoral head, femoral head necrosis, animal model, evaluation methods” as the retrieval words.
RESULTS AND CONCLUSION: A total of 51 articles were included according to the inclusion criteria, including 33 in Chinese and 18 in English. In recent years, with the development of imaging technology and the introduction of new technologies, the evaluation options of ONFH animal model increase. Choosing a reasonable evaluation method can reduce the workload in the process of establishing animal models and provide reference for the follow-up research. So, the further improvement is necessary.

Key words: osteonecrosis of the femoral head, animal model, evaluation method, imaging technology, review

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