关键词: 免疫抑制剂, 肾移植, 排斥反应, 环孢素A, 吗替麦考酚酯, 他克莫司

Abstract:

BACKGROUND: The key of the anti-rejection after kidney transplantation is how to use the synergies between different immunosuppressants in order to get the optimal efficacy. But, how to do the personalized medicine, improve the efficacy and avoid the adverse reactions occurrence is particularly important.
OBJECTIVE: To investigate the effect of different immunosuppressants on kidney transplant recipients and graft kidney survival, in order to avoid the adverse reactions.
METHODS: A computer-base search was performed on CNKI database from January 1999 to October 2009 for the relate articles with the key words of “immunosuppressant, kidney transplantation, rejection”. The articles relate to the immunosuppressant after kidney transplant were selected, and for the articles in the same fields, those published recently or in the authorized journals were selected. Finally, a total of 25 articles were included to review.
RESULTS AND CONCLUSION: Any kind of immunosuppressant has certain side effects when they play an immunosuppressive effect, so we should try to avoid the occurrence of the adverse reactions in clinic. The principle of combination therapy is the consensus in anti-rejection after kidney transplantation. It proves that no matter what combination approach we use, we can get the irreplaceable advantages that single medicine can not get. How to use the synergies between different immunosuppressants in order to get the optimal efficacy is the key in chinic. So doctors should closely monitor the blood concentration of the patients and insist on personalized medicine, in order to minimize the rejection rates after kidney transplantation.