中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (44): 8329-8332.doi: 10.3969/j.issn.1673-8225.2011.44.040

• 器官移植临床实践 clinical practice of organ transplantation • 上一篇    下一篇

肝移植治疗肝原发性鳞状细胞癌1例

邓荣海1，巫林伟1，吴成林1，王东平1，鞠卫强1，胡安斌1，邰  强1，朱晓峰1，韩安家2，何晓顺1   

  1. 1中山大学附属第一医院器官移植中心，广东省广州市  510080
    2中山大学附属第一医院病理科，广东省广州市 510080
  • 收稿日期:2011-05-07 修回日期:2011-07-15 出版日期:2011-10-29 发布日期:2011-10-29
  • 通讯作者: 何晓顺，博士，教授，博士生导师，中山大学附属第一医院器官移植中心，广东省广州市 510080 gdtrc@163.com
  • 作者简介:邓荣海☆，男，1981年生，广东省台山市人，汉族，中山大学在读博士，主要从事器官移植研究。 mddrh81@163.com
  • 基金资助:

    广东省科技计划项目(2008B030301308)。

Liver transplantation for treatment of primary squamous cell carcinoma of the liver in one case

Deng Rong-hai1, Wu Lin-wei1, Wu Cheng-lin1, Wang Dong-ping1, Ju Wei-qiang1, Hu An-bin1, Tai Qiang1, Zhu Xiao-feng1, Han An-jia2, He Xiao-shun1   

  1. 1Organ Transplantation Center, 2Department of Pathology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou  510080, Guangdong Province, China
  • Received:2011-05-07 Revised:2011-07-15 Online:2011-10-29 Published:2011-10-29
  • Contact: He Xiao-shun, Doctor, Professor, Doctoral supervisor, Organ Transplantation Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China gdtrc@163.com
  • About author:Deng Rong-hai☆, Studying for doctorate, Organ Transplantation Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China mddrh81@163.com
  • Supported by:

    the Science and Technology Project of Guangdong Province, No. 2008B030301308*

PDF

373

被引次数

5

摘要：

背景：肝原发性鳞状细胞癌较罕见，各种治疗方法疗效不佳，预后差。
目的：随访观察1例肝移植治疗肝原发性鳞状细胞癌患者的近期疗效。
方法：观察中山大学附属第一医院1例肝原发性鳞状细胞癌患者经肝移植治疗后的情况，并回顾性分析迄今为止见于文献报道的国内外65例肝原发性鳞状细胞癌的临床表现、组织来源、治疗方法及预后。
结果与结论：该患者经肝移植后肝功能恢复正常，肿瘤标志物癌胚抗原、糖类抗原199、鳞状细胞癌抗原等均降至正常水平，恢复良好。国内外研究表明，肝原发性鳞状细胞癌的临床表现不典型，组织来源多样，手术切除、化疗等治疗方法疗效不佳，预后差。本例结果显示，肝移植治疗肝原发性鳞状细胞癌近期疗效良好。

关键词: 肝移植, 肝脏, 鳞状细胞癌, 临床表现, 预后

Abstract:

BACKGROUND: Primary squamous cell carcinoma of the liver (PSCCL) is rare. Various treatments exhibit poor curative effects and prognosis.
OBJECTIVE: To investigate the short-term curative effects of liver transplantation in treatment of primary squamous cell carcinoma in one case.
METHODS: We analyzed the effect of liver transplantation in treating one case of primary squamous cell carcinoma of the liver in the First Affiliated Hospital of Sun Yat-sen University and retrospectively analyzed the clinical manifestations, tissue origin, therapeutic method and prognosis of 65 cases of the primary squamous cell carcinoma of the liver at home and abroad.
RESULTS AND CONCLUSION: The patient recovered well after liver transplantation, liver function returned to normal, tumor markers such as carcinoembryonic antigen, carbohydrate199 and squamous cell carcinoma antigen decreased to normal levels. Domestic and foreign data show that primary squamous cell carcinoma of the liver presents atypical clinical manifestations, variety of tissue sources, poor efficacy and prognosis of surgical excision, chemotherapy and other treatments. Results from the present case showed that liver transplantation for treatment of primary squamous cell carcinoma of the liver exhibits good curative effects, but further investigations are needed to estimate the long-term effect on such cases.

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