中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (25): 4719-4722.doi: 10.3969/j.issn.1673-8225.2011.25.039

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

组织工程支架材料在脊髓损伤修复中的应用

王新宏1，沈忆新1，范志海1，张  峰2   

  1. 1苏州大学附属第二医院骨科，江苏省苏州市 215004
    2 苏州大学材料工程学院，江苏省苏州市 215021
  • 收稿日期:2010-11-05 修回日期:2010-12-09 出版日期:2011-06-18 发布日期:2014-01-10
  • 通讯作者: 沈忆新，教授，硕士生导师，苏州大学附属第二医院骨科，江苏省苏州市 215004 shenyx@mail.szldbz.gov.cn
  • 作者简介:王新宏★，男，1985年生，山东省郓城县人，汉族，苏州大学在读硕士，主要从事脊柱脊髓的基础与临床研究。 xinhonghot@126.com
  • 基金资助:

    江苏省卫生厅面上科研课题(H200920)资助。

Application of tissue engineering scaffold materials in repair of spinal cord injury

Wang Xin-hong1, Shen Yi-xin1, Fan Zhi-hai1, Zhang Feng2   

  1. 1Department of Orthopaedics, the Second Affiliated Hospital of Soochow University, Suzhou   215004, Jiangsu Province, China
    2School of Materials Science and Engineering, Soochow University, Suzhou   215021, Jiangsu Province, China
  • Received:2010-11-05 Revised:2010-12-09 Online:2011-06-18 Published:2014-01-10
  • Contact: Shen Yi-xin, Professor, Master’s supervisor, Associate chief physician, Department of Orthopaedics, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China shenyx@mail.szldbz.gov.cn
  • About author:Wang Xin-hong★, Studying for master’s degree, Department of Orthopaedics, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu Province, China xinhonghot@126.com
  • Supported by:

    the Scientific Research Foundation of Health Committee of Jiangsu Province, No. H200920*

PDF

331

被引次数

25

摘要：

背景：脊髓损伤最初往往会导致细胞和组织的不断丢失，组织工程支架可以模拟细胞外基质的生理状态，从而有利于细胞的黏附、迁移、扩增和分化。
目的：总结近年来组织工程支架材料联合细胞和/或细胞因子修复脊髓损伤的新进展。
方法：应用计算机检索PubMed、Ovid Medline及CBM数据库中2000-10/2010-10 与组织工程支架材料修复脊髓损伤相关的文章。 
结果与结论：组织工程材料治疗脊髓损伤需要3 因素：种子细胞、组织工程支架、细胞因子。组织工程支架对于损伤脊髓断端起到桥接作用，而种植于材料的种子细胞和/或细胞因子可以促进神经轴突的生长和迁移。可用于组织工程支架的材料可分为天然材料和人工合成材料，包括胶原、壳聚糖、琼脂糖/藻酸盐、聚乳酸、纤连蛋白、聚羟基乙酸/聚乳酸、聚β羟丁酸等，动物实验已经取得一些成果，显示组织工程支架材料联合细胞移植修复效果更好，但临床上目前尚无开展组织工程支架材料修复脊髓损伤的研究。

关键词: 脊髓损伤, 组织工程支架, 组织工程, 种子细胞, 生物材料

Abstract:

BACKGROUND: Spinal cord injury (SCI) often leads to the continuous loss of cells and tissues initially. Tissue engineering scaffolds can simulate the physiological state of the extracellular matrix, which is conducive to cell adhesion, migration, proliferation and differentiation.
OBJECTIVE: To summarize the progress of tissue engineering scaffold materials combined with cells and (or) cytokines repairing SCI.
METHODS: The articles related to tissue engineering scaffold materials repairing SCI from PubMed database, Ovid Medline database and CBM database between October 2000 and October 2010 were retrieved by computer.
RESULTS AND CONCLUSION: Tissue engineering materials for repair of SCI need three elements: seed cells, tissue engineering scaffold, and cytokines. Tissue engineering scaffold plays a bridging role in broken ends of fractured bone of SCI; however, the seed cells and (or) cytokines can promote the growth and migration of neural axon. The materials that can be used for tissue engineering scaffold were divided into natural materials and synthetic materials, including collagen, chitosan, agarose/alginate, polylactic acid, fibronectin, polyglycolic acid/polylactic acid, poly-β hydroxybutyrate, etc. Animal experiments have obtained some achievements. Tissue engineering scaffold materials combined with cell transplantation have a better effect on repairing SCI. However, there is no research addressing tissue engineering scaffold materials repairing SCI currently.

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