中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (15): 2805-2808.doi: 10.3969/j.issn.1673-8225.2011.15.035

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

SDF-1/CXCR4信号通路在骨性关节炎病理进程中的作用

李晓林，李彦林，马 珂，曹 斌，王国梁，杨 光，许 鹏   

  1. 昆明医学院第一附属医院骨科，云南省昆明市  650031
  • 收稿日期:2010-10-19 修回日期:2011-03-05 出版日期:2011-04-09 发布日期:2013-11-06
  • 通讯作者: 李彦林，主任医师，教授，博士生导师，昆明医学院第一附属医院骨科，云南省昆明市 650031 yanlinli1969@ yahoo.com.cn
  • 作者简介:李晓林★，男，1983年生，云南省楚雄州姚安县人，汉族，昆明医学院第一附属医院骨科在读硕士，主要从事骨关节损伤的修复与重建方面的研究。 lixiaolinloveyou 83@126.com
  • 基金资助:

    国家自然科学基金资助项目(30860286)。

Role of SDF-1/CXCR4 signaling pathway in pathogenesis of osteoarthritis

Li Xiao-lin, Li Yan-lin, Ma Ke, Cao Bin, Wang Guo-liang, Yang Guang, Xu Peng   

  1. Department of Orthopedics, the First Affiliated Hospital of Kunming Medical College, Kunming  650031, Yunnan Province, China
  • Received:2010-10-19 Revised:2011-03-05 Online:2011-04-09 Published:2013-11-06
  • Contact: Li Yan-lin, Professor, Chief physician, Doctoral supervisor, Department of Orthopedics, the First Affiliated Hospital of Kunming Medical College, Kunming 650031, Yunnan Province, China yanlinli1969@yahoo.com.cn
  • About author:Li Xiao-lin★, Studying for master’s degree, Department of Orthopedics, the First Affiliated Hospital of Kunming Medical College, Kunming 650031, Yunnan Province, China lixiaolinloveyou83@ 126.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30860286*

PDF

771

被引次数

30

摘要：

背景：骨性关节炎的发病机制错综复杂，其预防与治疗是当今医学界的难题之一，与其相关的信号通路的研究已成为国内外研究的热点，其靶向治疗有望成为攻克骨性关节炎的关键。
目的：总结SDF-1/CXCR4信号通路在诸多疾病尤其是在骨性关节炎发病中的作用，为骨性关节炎的靶向治疗提供科学依据。
方法：应用计算机检索PubMed和CBM数据库中2008-09/2010-07发表的相关文献。以主题检索为主要检索方法，结合限定检索等方法，以“SDF-1/CXCR4信号通路、骨性关节炎”和“SDF-1/CXC4 signaling pathway, osteoarthritis”为中英文检索词，选择与骨性关节炎SDF-1/CXCR4信号通路有关的文献，排除内容陈旧、重复的文章。
结果与结论：共检索到2 147篇文章，按纳入和排除标准对文献进行筛选，保留32篇文章进行综述。目前，SDF-1/CXCR4信号通路在诸多疾病的发生发展过程中具有重要作用，已成为目前世界医学的研究热点之一。有研究表明，SDF-1/CXCR4信号通路可能在骨性关节炎的发病中具有重要作用，而对该信号通路的干预可能成为预防与治疗骨性关节炎的靶点，有望成为今后骨性关节炎防治方面研究的热点。

关键词: 骨性关节炎, SDF-1, CXCR4, 信号通路, 靶向治疗

Abstract:

BACKGROUND: The pathogenesis of osteoarthritis (OA) is very complex, the prevention and treatment of OA is a medical challenge, and the signaling pathway related to OA is becoming the hot spot of current researches. The targeted therapy may be the key to treat OA.
OBJECTIVE: To discuss the role of SDF-1/CXCR4 signaling pathway in many diseases and the pathogenesis of OA, and to provide the basis of targeted therapy on OA.
METHODS: CBM and PubMed were retrieved by computer using key words of “SDF-1; CXCR4 signaling pathway; Osteoarthritis” both in Chinese and English, with the method of subject index combined with limited index. The papers which included the two themes were accepted, and those which had old and duplicate contents were excluded.
RESULTS AND CONCLUSIONS: Of 2 147 retrieved articles, only 32 papers were involved in result analysis. SDF-1/CXCR4 signaling pathway, with its important role in many diseases, is becoming the research focus of current medical associates. SDF-1/CXCR4 signaling pathway possibly has important effect on OA. The targeted therapy on OA may be the key of the treatment of OA.

中图分类号: