关键词: 冠状动脉内支架, 表面涂层, 血栓, 再狭窄, 生物材料　

Abstract:

OBJECTIVE: To describe the clinical application of intracoronary stent, and to explore the surface coating materials of coronary stent for stent thrombosis and restenosis after implantation.
METHODS: Using “intracoronary stent, surface coating, thrombosis, restenosis” in Chinese as the key words, China Academic Journal Full-text database (CNKI: 2002/2008) and Medline databases (Pubmed: 1974/2006) were retrieved online. Meta analysis and reproducible study were excluded. A total of 25 articles were screened out, discussing the progress of intracoronary stent implantation treatment, different surface coating materials and their influence on the thrombosis and restenosis.
RESULTS: Drug-eluting intracoronary stent is a common method of treating coronary heart disease, with remarkable effect and rare complications. Intracoronary stent surface coating materials include rapamycin, paclitaxel, heparin, diallyl sulfide, dexamethasone, and non-degradable polymers, they can promote endothelial cells repair, inhibit smooth muscle cells proliferation, prevent stent thrombosis and restenosis, and maintain stent patency. The residual coating materials stimulate smooth muscle cells to proliferate, biodegradable polymer coating which is used in recent years can improve the patency rate of the stent. Heparinized polyurethane coatings, poly lactic acid glycolic acid copolymer rapamycin coating and polysulfone-polyethylene oxide copolymer coating have good histocompatibility, inhibit intimal hyperplasia and improve the restenosis, they are expected to become a new intracoronary stent coating material.
CONCLUSION: Intracoronary drug-eluting stent implantation in combination with aspirin and clopidogrel is a good method for coronary revascularization, with the coating materials continuously update; stent patency rates will be further enhanced.