中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (53): 9902-9904.doi: 10.3969/j.issn.1673-8225.2010.53.005

• 心肺移植 heart-lung transplantation • 上一篇    下一篇

同种异体犬单肺移植过程中的凝血功能

吴安石，周海滨，张雪娜，岳  云   

  1. 首都医科大学附属北京朝阳医院麻醉科，北京市   100020
  • 出版日期:2010-12-31 发布日期:2010-12-31
  • 通讯作者: 岳云，主任医师，首都医科大学附属北京朝阳医院麻醉科，北京市 100020 yueyun@hotmail.com
  • 作者简介:吴安石☆，男， 1965年生，湖北省咸宁市人，汉族，2002年首都医科大学毕业，博士，主任医师，主要从事麻醉与脑、肺保护研究。 wuanshi@hotmail.com

Function changes of blood coagulation in dogs during single lung transplantation

Wu An-shi, Zhou Hai-bin, Zhang Xue-na, Yue Yun   

  1. Department of Anesthesiology, Beijing Chao Yang Hospital, Capital Medical University, Beijing   100020, China
  • Online:2010-12-31 Published:2010-12-31
  • About author:Wu An-shi☆, Doctor, Chief physician, Department of Anesthesiology, Beijing Chao Yang Hospital, Capital Medical University, Beijing 100020, China wuanshi@hotmail.com

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346

被引次数

1

摘要：

背景：体外循环条件下，肺移植围手术期有凝血和纤溶系统的激活，而对非体外循环下肺移植围手术期凝血功能变化研究较少。
目的：检测受体犬单肺移植过程中凝血功能的变化。
方法：将健康杂种雄性犬以随机抽签法分成供体和受体两组，行单肺移植，分别于麻醉诱导后20 min，再灌注前10 min，再灌注后10 min，再灌注后60 min，采用Sonoclot凝血仪检测受体犬全血激活凝集时间、凝集速率、血小板功能。
结果与结论：再灌注后10 min全血激活凝集时间数值较麻醉诱导后20 min，再灌注前10 min，再灌注后60 min明显延长(P < 0.001)。凝集速率和血小板功能各组之间差异均无显著性意义。说明犬肺移植过程中全血激活凝集时间在再灌注后10 min明显延长，再灌注后1 h 回到正常水平，凝集速率和血小板功能在各个时点变化不大。

关键词: 单肺移植, Sonoclot凝血仪, 凝血功能, 异体, 器官移植

Abstract:

BACKGROUND: During the perioperative period of lung transplantation, there is activation of blood coagulation and fibrionlytic system in extracorporeal circulation. But the research addressing function changes of blood coagulation during the perioperative off-pump period of lung transplantation is relatively rare.
OBJECTIVE: To detect the function changes of blood coagulation in recipient dogs during single lung transplantation.
METHODS: Twenty-four healthy male dogs were randomly divided into donor group and recipient group, followed by single lung transplantation. Activated clotting time (ACT), clotting rate (CR), and platelet function (PF) in the recipient group were detected with Sonoclot coagulometer respectively at 20 minutes after anesthesia induction (T1), 10 minutes before reperfusion (T2), 10 minutes after reperfusion (T3) and 60 minutes after reperfusion (T4).  
RESULTS AND CONCLUSION: Activated clotting time of T3 was obviously longer than T1, T2, and T4 (P < 0.001). CR and PF had no significant changes among the groups. These indicated that during the lung transplantation, activated clotting time was obviously prolonged 10 minutes after reperfusion, and returned to normal level one hour after reperfusion. CR and PF had no obvious changes at different time point.

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