关键词: 痛风颗粒, 腺嘌呤, 乙胺丁醇, 高尿酸性肾病, 病理形态学, 组织构建

Abstract:

BACKGROUND: Over the years, we have obtained a good effect of tongfeng instant powder on uric acid nephropathy and gouty arthritis through long-term and large-amount clinical practice.
OBJECTIVE: To observe the pathological changes of the kidneys in rats with hyperuricemia nephropathy after the treatment with tongfeng instant powder.
METHODS: Sixty-six Sprague-Dawley rats were randomized into six groups: normal control group, model group, benzbromarone group, high-, middle-, and low-dose tongfeng instant powder groups. Animal models of hyperuricemia nephropathy were established in the latter five groups. All groups were treated with tongfeng instant powder or benzbromarone or the same volume of saline solution per day until day 21 after modeling.
RESULTS AND CONCLUSION: Compared with the model group, the renal mass was reduced significantly, while the body mass was increased significantly in the treatment groups and normal control group (P < 0.05). The renal structure in the normal control group maintained normal. There was focal interstitial fibrosis in the model group, with a large number of infiltrated lymphoid tissue and monocytes. In the high-dose group, rare interstitial fibrosis was seen, accompanied by a small amount of infiltrated lymphoid tissues and monocytes. In the middle-dose group, a little interstitial fibrosis was seen, accompanied by a small amount of infiltrated lymphoid tissue and monocytes. In the low-dose group, a great amount of interstitial fibrosis was found with a large amount of infiltrated lymphoid tissue and monocytes. In the benzbromarone group, a small amount of interstitial fibrosis was observed, accompanied by a large number of infiltrated lymphoid tissue and monocytes. These findings indicate that tongfeng instant powder can effectively suppress the renal inflammation of hyperuricemia nephropathy animal models and reduce renal interstitial fibrosis and glomerular sclerosis.