中国组织工程研究 ›› 2023, Vol. 27 ›› Issue (32): 5219-5226.doi: 10.12307/2023.827
• 组织构建综述 tissue construction review • 上一篇 下一篇
冷思逸1,蒲 锐1,2,陈子扬1,2,杨启航1,宋永晶1,刘 辉3
收稿日期:
2022-11-03
接受日期:
2022-12-09
出版日期:
2023-11-18
发布日期:
2023-03-23
通讯作者:
宋永晶,博士,副教授,硕士研究生导师,长江大学教育与体育学院,湖北省荆州市 434023
蒲锐,男,硕士,讲师,长江大学教育与体育学院,湖北省荆州市 434023
作者简介:
冷思逸,女,1999年生,湖北省武汉市人,汉族,在读硕士,主要从事运动健康促进研究。
基金资助:
Leng Siyi1, Pu Rui1, 2, Chen Ziyang1, 2, Yang Qihang1, Song Yongjing1, Liu Hui3
Received:
2022-11-03
Accepted:
2022-12-09
Online:
2023-11-18
Published:
2023-03-23
Contact:
Song Yongjing, MD, Associate professor, Master’s supervisor, College of Education and Sports Sciences, Yangtze University, Jingzhou 434023, Hubei Province, China
Pu Rui, Master, Lecturer, College of Education and Sports Sciences, Yangtze University, Jingzhou 434023, Hubei Province, China; Human Science Laboratory of Exercise, Yangtze University, Jingzhou 434023, Hubei Province, China
About author:
Leng Siyi, Master candidate, College of Education and Sports Sciences, Yangtze University, Jingzhou 434023, Hubei Province, China
Supported by:
摘要:
文题释义:
肠道菌群:是人体内最复杂和种群数量最高的共生微生物生态系统,对机体的代谢、营养和调节等发挥着重要作用,是近年来防治自身免疫性疾病相关研究的热点之一。
肠道菌群对自身免疫性疾病的作用及运动干预:运动可通过调节肠道菌群改善肠道屏障功能、抑制炎症反应、调节肠道菌群稳态和改善血糖稳态,进而在1型糖尿病、乳糜泻、炎症性肠病、多发性硬化症和强直性脊柱炎等自身免疫性疾病的预防与治疗中发挥免疫系统的保护作用。
背景:肠道菌群主要负责维持宿主防御和免疫耐受之间的平衡。此外,肠道菌群与自身免疫性疾病关系密切,且运动可对肠道菌群具有重要调控作用,进而影响着各类自身免疫性疾病的发生发展。
目的:总结肠道菌群对1型糖尿病、乳糜泻、炎症性肠病、多发性硬化症和强直性脊柱炎等不同自身免疫性疾病的作用,并围绕运动对肠道菌群的影响以及运动调控肠道菌群对自身免疫性保护的作用进行分析,旨在为自身免疫性疾病的防治提供新的参考与依据。
方法:以“Intestinal flora,intestinal bacteria,autoimmune diseases,type 1 diabetes,celiac disease,inflammatory bowel disease,multiple sclerosis,ankylosing spondylitis,exercise”和“肠道菌群、肠道细菌、自身免疫性疾病、1型糖尿病、乳糜泻、炎症性肠病、多发性硬化症、强直性脊柱炎、运动”为关键词,检索PubMed和CNKI数据库1996-2022年间相关文献。根据纳入排除标准选择90篇文献进行综述。
结果与结论:①1型糖尿病、乳糜泻、炎症性肠病、多发性硬化症和强直性脊柱炎等自身免疫性疾病受到肠道菌群的影响,且肠道菌群在自身免疫性疾病的调控中发挥关键作用。②不同运动方式对肠道菌群的影响不同,有氧运动可增加机体中肠道菌群多样性和菌群丰度,改善肠道黏膜免疫屏障功能,降低机体代谢性炎症反应,从而促进健康增强机体抵抗力。但有氧运动调控肠道菌群促进机体健康的途径和具体机制需要进一步研究。无氧运动对机体肠道菌群的影响研究尚存争议,可能与研究对象、研究方法、运动干预的时间强度异质性有关,需要进一步深层次挖掘,但研究均表明无氧运动可通过减轻机体炎症反应、提高胰岛素耐受能力和改善糖脂代谢紊乱,进而改善机体健康。③运动可通过调控肠道菌群改善肠道屏障功能、抑制炎症反应、调节肠道菌群稳态和改善血糖稳态等在自身免疫性疾病的防治中发挥重要作用,为运动促进机体健康及自身免疫性疾病的防治提供了新的思路与策略。
https://orcid.org/0000-0001-5097-5445(冷思逸)
中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程
中图分类号:
冷思逸, 蒲 锐, 陈子扬, 杨启航, 宋永晶, 刘 辉. 运动干预肠道菌群对自身免疫性疾病的作用[J]. 中国组织工程研究, 2023, 27(32): 5219-5226.
Leng Siyi, Pu Rui, Chen Ziyang, Yang Qihang, Song Yongjing, Liu Hui. Roles of exercise intervention in intestinal flora in autoimmune diseases[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(32): 5219-5226.
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1.1.6 检索策略 以PubMed数据库为例,见图1。
1.1.7 检索文献量 检索文献总数量2 736篇,包括英文2 266篇、中文470篇。
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文题释义:#br# 肠道菌群:是人体内最复杂和种群数量最高的共生微生物生态系统,对机体的代谢、营养和调节等发挥着重要作用,是近年来防治自身免疫性疾病相关研究的热点之一。#br# 肠道菌群对自身免疫性疾病的作用及运动干预:运动可通过调节肠道菌群改善肠道屏障功能、抑制炎症反应、调节肠道菌群稳态和改善血糖稳态,进而在1型糖尿病、乳糜泻、炎症性肠病、多发性硬化症和强直性脊柱炎等自身免疫性疾病的预防与治疗中发挥免疫系统的保护作用。#br# 中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程
近年来,研究者们发现肠道菌群与自身免疫性疾病的发生发展存在密切联系,肠道菌群可通过饮食、抗生素、益生菌和菌群移植等不同方式调节肠道菌群改善自身免疫性疾病,且运动可有效改善肠道菌群的组成和多样性,进而改善肠屏障功能、抑制炎症反应等。然而,现阶段关于肠道菌群及其代谢产物对自身免疫性疾病作用的具体分子机制仍需完善;不同运动方式、运动时间、运动强度等对肠道菌群的影响及其差异需进一步深入研究;同时运动干预肠道菌群发挥防治自身免疫性疾病的相互作用机制等问题尚未阐明。该综述总结了目前学者关于不同运动干预对肠道菌群的影响以及运动调控肠道菌群防治自身免疫性疾病的相关研究结果。重点介绍了运动干预对肠道菌群的影响,如有氧运动可调节肠道菌群、减轻机体炎症反应、增加肠道菌群丰度和改善免疫功能;与有氧运动相比,无氧运动并未改变肠道菌群组成,无氧运动对机体肠道菌群的影响研究尚存争议,可能与研究对象、研究方法、运动干预的时间强度异质性有关。
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