中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (5): 809-814.doi: 10.3969/j.issn.2095-4344.2017.05.025

• 干细胞综述 stem cell review • 上一篇    下一篇

辛伐他汀调控内源性干细胞进行退变椎间盘的内源性修复和重建

黄泽楠,冯新民,王静成,陈  涛,毕松超,张  亮   

  1. 扬州大学医学院,扬州大学临床医学院,江苏省扬州市  225001
  • 出版日期:2017-02-18 发布日期:2017-03-20
  • 通讯作者: 张亮,副主任医师,讲师,扬州大学临床医学院,江苏省扬州市 225001
  • 作者简介:黄泽楠,男,1991年生,江苏省泰兴市人,硕士研究生,主要从事脊柱外科方面的研究。
  • 基金资助:

    国家自然科学基金(青年基金项目,81401830);中国博士后科学基金资助(2015M571714);江苏省自然科学基金(青年基金项目,BK 20140496)

Simvastatin regulates endogenous stem cells to reconstruct the degenerative intervertebral disc

Huang Ze-nan, Feng Xin-min, Wang Jing-cheng, Chen Tao, Bi Song-chao, Zhang Liang   

  1. Clinical Medical College of Yangzhou University, Yangzhou 225001, Jiangsu Province, China
  • Online:2017-02-18 Published:2017-03-20
  • Contact: Zhang Liang, Associate chief physician, Lecturer, Medical College of Yangzhou University, Yangzhou 225001, Jiangsu Province, China
  • About author:Huang Ze-nan, Studying for master’s degree, Medical College of Yangzhou University, Yangzhou 225001, Jiangsu Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81401830; the China Postdoctoral Science Foundation, No. 2015M571714; the Natural Science Foundation of Jiangsu Province, No. BK 20140496

摘要:

文章快速阅读:

文题释义:
低氧诱导因子:
是一类介导细胞内低氧反应的关键性转录调控因子,目前哺乳动物体内有3种(HIF-1,HIF-2,HIF-3),常氧时表达很低,低氧时能迅速转移质细胞核,使缺氧诱导基因转录增强,表达产物增多。
髓核:是乳白色半透明胶状体,富于弹性,为椎间盘结构的一部分,位于两软骨板与纤维环之间。由纵横交错的纤维网状结构即软骨细胞和蛋白多糖黏液样基质构成的弹性胶冻物质。

 

摘要
背景
:研究显示,他汀类药物能够促进椎间盘细胞骨形态发生蛋白2、聚集蛋白聚糖及Ⅱ型胶原等细胞外基质mRNA达,同时也能使已去分化的髓核细胞表型发生逆转,从而能减缓椎间盘退变过程。
目的:综述近年来国内外研究辛伐他汀诱导干细胞生物学活性及动员内源性干细胞修复退变椎间盘的研究进展。
方法:由第一作者检索至2016年1月为止PubMed及CNKI中国期刊全文数据库,以“椎间盘退变治疗,内源性干细胞和退变的椎间盘,辛伐他汀和干细胞”等为检索词,共检索102篇相关文献,排除重复研究,共48篇文献符合纳入标准。
结果与结论:综合大量国内外科研人员对椎间盘退变治疗的研究,发现辛伐他汀可以促进低氧诱导因子1α的表达,同时低氧诱导因子1α又可以调控退变的椎间盘组织中的髓核间充质干细胞的生物学行为。因此,辛伐他汀能够通过此途径来进行退变椎间盘的内源性修复和重建。

 

中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
ORCID:
0000-0002-9746-1828(黄泽楠)

关键词: 干细胞, 分化, 椎间盘退变, 低氧诱导因子1α, 辛伐他汀, 髓核间充质干细胞, 国家自然科学基金

Abstract:

BACKGROUND: Statins can promote the mRNA expression of bone morphogenetic protein 2, aggrecan and type II collagen in intervertebral disc cells, and they also can reverse the phenotype of dedifferentiated nucleus pulposus cells to slow disc degeneration process.
OBJECTIVE: To review the research progress of simvastatin modulating the biological characteristics and mobilizing endogenous stem cells for the repair of intervertebral disc degeneration. 
METHODS: The first author retrieved the PubMed and CNKI databases for relevant articles published before January 2016 using the key words of “disc degeneration factor, Simvastatin AND stem cells, endogenous stem cells AND disc degeneration” in English and Chinese, respectively. Initially, 102 relevant articles were retrieved, but only 48 articles were included in result analysis following elimination of duplicate studies.
RESULTS AND CONCLUSION: By summarizing a large number of studies on the treatment of intervertebral disc degeneration worldwide, we found that simvastatin may modulate the biological characteristics and function of nucleus pulposus mesenchymal stem cells via promoting the expression of hypoxia-inducible factor 1α for the endogenous stem cell-based therapy of intervertebral disc degeneration.

 

中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程

Key words: Hypoxia-Inducible Factor 1, Mesenchymal Stem Cells, Intervertebral Disk, Tissue Engineering

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