[1] DA SILVA MEIRELLES L, CHAGASTELLES PC, NARDI NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci. 2006;119(Pt 11):2204-2213.
[2] PITTENGER MF, MACKAY AM, BECK SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284(5411):143-147.
[3] KIERNAN J, DAVIES JE, STANFORD WL. Concise Review: Musculoskeletal Stem Cells to Treat Age-Related Osteoporosis. Stem Cells Transl Med. 2017;6(10):1930-1939.
[4] WATSON L, ELLIMAN SJ, COLEMAN CM. From isolation to implantation: a concise review of mesenchymal stem cell therapy in bone fracture repair. Stem Cell Res Ther. 2014;5(2):51.
[5] MOON MY, KIM HJ, CHOI BY, et al. Zinc Promotes Adipose-Derived Mesenchymal Stem Cell Proliferation and Differentiation towards a Neuronal Fate. Stem Cells Int. 2018;2018:5736535.
[6] WONG SP, ROWLEY JE, REDPATH AN, et al. Pericytes, mesenchymal stem cells and their contributions to tissue repair. Pharmacol Ther. 2015;151:107-120.
[7] HARRELL CR, JOVICIC N, DJONOV V, et al. Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases. Cells. 2019;8(12):1605.
[8] HU C, LI L. Preconditioning influences mesenchymal stem cell properties in vitro and in vivo. J Cell Mol Med. 2018;22(3):1428-1442.
[9] HE C, WANG L, ZHANG J, et al. Hypoxia-inducible microRNA-224 promotes the cell growth, migration and invasion by directly targeting RASSF8 in gastric cancer. Mol Cancer. 2017;16(1):35.
[10] KIMURA W, NAKADA Y, SADEK HA. Hypoxia-induced myocardial regeneration. J Appl Physiol (1985). 2017;123(6):1676-1681.
[11] WANG F, ZACHAR V, PENNISI CP, et al. Hypoxia Enhances Differentiation of Adipose Tissue-Derived Stem Cells toward the Smooth Muscle Phenotype. Int J Mol Sci. 2018;19(2):517.
[12] CHOI JR, PINGGUAN-MURPHY B, WAN ABAS WA, et al. Impact of low oxygen tension on stemness, proliferation and differentiation potential of human adipose-derived stem cells. Biochem Biophys Res Commun. 2014;448(2):218-224.
[13] HUNG SP, HO JH, SHIH YR, et al. Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells. J Orthop Res. 2012;30(2):260-266.
[14] FOTIA C, MASSA A, BORIANI F, et al. Hypoxia enhances proliferation and stemness of human adipose-derived mesenchymal stem cells. Cytotechnology. 2015;67(6):1073-1084.
[15] DRELA K, SARNOWSKA A, SIEDLECKA P, et al. Low oxygen atmosphere facilitates proliferation and maintains undifferentiated state of umbilical cord mesenchymal stem cells in an hypoxia inducible factor-dependent manner. Cytotherapy. 2014;16(7):881-892.
[16] LAMPERT FM, KÜTSCHER C, STARK GB, et al. Overexpression of Hif-1α in Mesenchymal Stem Cells Affects Cell-Autonomous Angiogenic and Osteogenic Parameters. J Cell Biochem. 2016;117(3):760-768.
[17] PARK IH, KIM KH, CHOI HK, et al. Constitutive stabilization of hypoxia-inducible factor alpha selectively promotes the self-renewal of mesenchymal progenitors and maintains mesenchymal stromal cells in an undifferentiated state. Exp Mol Med. 2013;45(9):e44.
[18] ZHU Y, ZHANG X, GU R, et al. LAMA2 regulates the fate commitment of mesenchymal stem cells via hedgehog signaling. Stem Cell Res Ther. 2020;11(1):135.
[19] JUN EK, ZHANG Q, YOON BS, et al. Hypoxic conditioned medium from human amniotic fluid-derived mesenchymal stem cells accelerates skin wound healing through TGF-β/SMAD2 and PI3K/Akt pathways. Int J Mol Sci. 2014;15(1):605-628.
[20] ZHANG S, HU B, LIU W, et al. Articular cartilage regeneration: The role of endogenous mesenchymal stem/progenitor cell recruitment and migration. Semin Arthritis Rheum. 2020;50(2):198-208.
[21] OH SY, LEE SJ, JUNG YH, et al. Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation. Cell Death Dis. 2015;6(5):e1750.
[22] LI L, JAISWAL PK, MAKHOUL G, et al. Hypoxia modulates cell migration and proliferation in placenta-derived mesenchymal stem cells. J Thorac Cardiovasc Surg. 2017;154(2):543-552.e3.
[23] VERTELOV G, KHARAZI L, MURALIDHAR MG, et al. High targeted migration of human mesenchymal stem cells grown in hypoxia is associated with enhanced activation of RhoA. Stem Cell Res Ther. 2013;4(1):5.
[24] LIU X, DUAN B, CHENG Z, et al. SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion. Protein Cell. 2011;2(10):845-854.
[25] MARTINEZ VG, ONTORIA-OVIEDO I, RICARDO CP, et al. Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells. Stem Cell Res Ther. 2017;8(1):208.
[26] MAO Q, LIANG XL, WU YF, et al. ILK promotes survival and self-renewal of hypoxic MSCs via the activation of lncTCF7-Wnt pathway induced by IL-6/STAT3 signaling. Gene Ther. 2019;26(5):165-176.
[27] BOYETTE LB, CREASEY OA, GUZIK L, et al. Human bone marrow-derived mesenchymal stem cells display enhanced clonogenicity but impaired differentiation with hypoxic preconditioning. Stem Cells Transl Med. 2014;3(2):241-254.
[28] YANG DC, YANG MH, TSAI CC, et al. Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST. PLoS One. 2011;6(9):e23965.
[29] BENJAMIN S, SHEYN D, BEN-DAVID S, et al. Oxygenated environment enhances both stem cell survival and osteogenic differentiation. Tissue Eng Part A. 2013;19(5-6):748-758.
[30] WAGEGG M, GABER T, LOHANATHA FL, et al. Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner. PLoS One. 2012;7(9):e46483.
[31] VALORANI MG, MONTELATICI E, GERMANI A, et al. Pre-culturing human adipose tissue mesenchymal stem cells under hypoxia increases their adipogenic and osteogenic differentiation potentials. Cell Prolif. 2012;45(3):225-238.
[32] YOO HI, MOON YH, KIM MS. Effects of CoCl2 on multi-lineage differentiation of C3H/10T1/2 mesenchymal stem cells. Korean J Physiol Pharmacol. 2016;20(1):53-62.
[33] VALORANI MG, GERMANI A, OTTO WR, et al. Hypoxia increases Sca-1/CD44 co-expression in murine mesenchymal stem cells and enhances their adipogenic differentiation potential. Cell Tissue Res. 2010;341(1):111-120.
[34] KANICHAI M, FERGUSON D, PRENDERGAST PJ, et al. Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: a role for AKT and hypoxia-inducible factor (HIF)-1alpha. J Cell Physiol. 2008;216(3):708-715.
[35] FELKA T, SCHÄFER R, SCHEWE B, et al. Hypoxia reduces the inhibitory effect of IL-1beta on chondrogenic differentiation of FCS-free expanded MSC. Osteoarthritis Cartilage. 2009;17(10):1368-1376.
[36] HAN YS, LEE JH, YOON YM, et al. Hypoxia-induced expression of cellular prion protein improves the therapeutic potential of mesenchymal stem cells. Cell Death Dis. 2016;7(10):e2395.
[37] TOMA C, PITTENGER MF, CAHILL KS, et al. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation. 2002;105(1):93-98.
[38] XIA W, ZHUANG L, HOU M. Role of lincRNA‑p21 in the protective effect of macrophage inhibition factor against hypoxia/serum deprivation‑induced apoptosis in mesenchymal stem cells. Int J Mol Med. 2018;42(4):2175-2184.
[39] HOU M, LIU J, LIU F, et al. C1q tumor necrosis factor-related protein-3 protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis through the phosphoinositide 3-kinase/Akt pathway. Int J Mol Med. 2014;33(1):97-104.
[40] WANG XY, FAN XS, CAI L, et al. Lysophosphatidic acid rescues bone mesenchymal stem cells from hydrogen peroxide-induced apoptosis. Apoptosis. 2015;20(3):273-284.
[41] YUN CW, LEE SH. Potential and Therapeutic Efficacy of Cell-based Therapy Using Mesenchymal Stem Cells for Acute/chronic Kidney Disease. Int J Mol Sci. 2019;20(7):1619.
[42] HAN Y, LI X, ZHANG Y, et al. Mesenchymal Stem Cells for Regenerative Medicine. Cells. 2019;8(8):886.
[43] LIEBERGALL M, SCHROEDER J, MOSHEIFF R, et al. Stem cell-based therapy for prevention of delayed fracture union: a randomized and prospective preliminary study. Mol Ther. 2013;21(8):1631-1638.
[44] GORABI AM, KIAIE N, BARRETO GE, et al. The Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes in Treatment of Neurodegenerative Diseases. Mol Neurobiol. 2019;56(12):8157-8167.
[45] CHEN C, HOU J. Mesenchymal stem cell-based therapy in kidney transplantation. Stem Cell Res Ther. 2016;7:16.
[46] XU T, ZHANG Y, CHANG P, et al. Mesenchymal stem cell-based therapy for radiation-induced lung injury. Stem Cell Res Ther. 2018;9(1):18.
[47] LIN W, XU L, PAN Q, et al. Lgr5-overexpressing mesenchymal stem cells augment fracture healing through regulation of Wnt/ERK signaling pathways and mitochondrial dynamics. FASEB J. 2019;33(7):8565-8577.
[48] KATAGIRI W, WATANABE J, TOYAMA N, et al. Clinical Study of Bone Regeneration by Conditioned Medium From Mesenchymal Stem Cells After Maxillary Sinus Floor Elevation. Implant Dent. 2017;26(4):607-612.
[49] MOHYELDIN A, GARZÓN-MUVDI T, QUIÑONES-HINOJOSA A. Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell. 2010;7(2):150-161.
[50] HO SS, HUNG BP, HEYRANI N, et al. Hypoxic Preconditioning of Mesenchymal Stem Cells with Subsequent Spheroid Formation Accelerates Repair of Segmental Bone Defects. Stem Cells. 2018;36(9):1393-1403.
[51] BEEGLE J, LAKATOS K, KALOMOIRIS S, et al. Hypoxic preconditioning of mesenchymal stromal cells induces metabolic changes, enhances survival, and promotes cell retention in vivo. Stem Cells. 2015;33(6):1818-1828.
[52] LIU W, LI L, RONG Y, et al. Hypoxic mesenchymal stem cell-derived exosomes promote bone fracture healing by the transfer of miR-126. Acta Biomater. 2020;103:196-212.
[53] HUANG B, QIAN J, MA J, et al. Myocardial transfection of hypoxia-inducible factor-1α and co-transplantation of mesenchymal stem cells enhance cardiac repair in rats with experimental myocardial infarction. Stem Cell Res Ther. 2014;5(1):22.
[54] CHENG J, ZHANG P, JIANG H. Let-7b-mediated pro-survival of transplanted mesenchymal stem cells for cardiac regeneration. Stem Cell Res Ther. 2015;6:216.
[55] ZHU LP, TIAN T, WANG JY, et al. Hypoxia-elicited mesenchymal stem cell-derived exosomes facilitates cardiac repair through miR-125b-mediated prevention of cell death in myocardial infarction. Theranostics. 2018;8(22):6163-6177.
[56] HU X, WU R, SHEHADEH LA, et al. Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells. BMC Genomics. 2014;15:303.
[57] HU X, WU R, JIANG Z, et al. Leptin signaling is required for augmented therapeutic properties of mesenchymal stem cells conferred by hypoxia preconditioning. Stem Cells. 2014;32(10):2702-2713.
[58] CHEN P, WU R, ZHU W, et al. Hypoxia preconditioned mesenchymal stem cells prevent cardiac fibroblast activation and collagen production via leptin. PLoS One. 2014;9(8):e103587.
[59] WANG Y, FENG C, XUE J, et al. Adenovirus-mediated hypoxia-inducible factor 1alpha double-mutant promotes differentiation of bone marrow stem cells to cardiomyocytes. J Physiol Sci. 2009;59(6):413-420.
[60] ZHOU J, NOORI H, BURKOVSKIY I, et al. Modulation of the Endocannabinoid System Following Central Nervous System Injury. Int J Mol Sci. 2019;
20(2):388.
[61] OPPLIGER B, JOERGER-MESSERLI M, MUELLER M, et al. Intranasal Delivery of Umbilical Cord-Derived Mesenchymal Stem Cells Preserves Myelination in Perinatal Brain Damage. Stem Cells Dev. 2016;25(16): 1234-1242.
[62] VAN VELTHOVEN CT, VAN DE LOOIJ Y, KAVELAARS A, et al. Mesenchymal stem cells restore cortical rewiring after neonatal ischemia in mice. Ann Neurol. 2012;71(6):785-796.
[63] GAZDIC M, ARSENIJEVIC A, MARKOVIC BS, et al. Mesenchymal Stem Cell-Dependent Modulation of Liver Diseases. Int J Biol Sci. 2017;13(9): 1109-1117.
[64] DU Z, WEI C, CHENG K, et al. Mesenchymal stem cell-conditioned medium reduces liver injury and enhances regeneration in reduced-size rat liver transplantation. J Surg Res. 2013;183(2):907-915.
[65] LAVRENTIEVA A, MAJORE I, KASPER C, et al. Effects of hypoxic culture conditions on umbilical cord-derived human mesenchymal stem cells. Cell Commun Signal. 2010;8:18.
[66] QIN HH, FILIPPI C, SUN S, et al. Hypoxic preconditioning potentiates the trophic effects of mesenchymal stem cells on co-cultured human primary hepatocytes. Stem Cell Res Ther. 2015;6:237.
[67] KUPPE C, KRAMANN R. Role of mesenchymal stem cells in kidney injury and fibrosis. Curr Opin Nephrol Hypertens. 2016;25(4):372-377.
[68] YU X, LU C, LIU H, et al. Hypoxic preconditioning with cobalt of bone marrow mesenchymal stem cells improves cell migration and enhances therapy for treatment of ischemic acute kidney injury. PLoS One. 2013; 8(5):e62703.
[69] ZHANG W, LIU L, HUO Y, et al. Hypoxia-pretreated human MSCs attenuate acute kidney injury through enhanced angiogenic and antioxidative capacities. Biomed Res Int. 2014;2014:462472.
[70] BEHNKE J, KREMER S, SHAHZAD T, et al. MSC Based Therapies-New Perspectives for the Injured Lung. J Clin Med. 2020;9(3):682.
[71] LAN YW, CHOO KB, CHEN CM, et al. Hypoxia-preconditioned mesenchymal stem cells attenuate bleomycin-induced pulmonary fibrosis. Stem Cell Res Ther. 2015;6(1):97.
[72] LI B, LI C, ZHU M, et al. Hypoxia-Induced Mesenchymal Stromal Cells Exhibit an Enhanced Therapeutic Effect on Radiation-Induced Lung Injury in Mice due to an Increased Proliferation Potential and Enhanced Antioxidant Ability. Cell Physiol Biochem. 2017;44(4):1295-1310.
[73] DAS R, JAHR H, VAN OSCH GJ, et al. The role of hypoxia in bone marrow-derived mesenchymal stem cells: considerations for regenerative medicine approaches. Tissue Eng Part B Rev. 2010;16(2):159-168.
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