中国组织工程研究 ›› 2020, Vol. 24 ›› Issue (21): 3416-3422.doi: 10.3969/j.issn.2095-4344.2575

• 骨与关节综述 bone and joint review • 上一篇    下一篇

生物携氧治疗剂的研究:作用与应用

娜飞沙·斯马义,陈莉智,王相朦,黄文华   

  1. 南方医科大学基础医学院人体解剖学国家重点学科,广东省广州市  510515
  • 收稿日期:2019-08-30 修回日期:2019-08-31 接受日期:2019-10-26 出版日期:2020-07-28 发布日期:2020-04-19
  • 通讯作者: 黄文华,教授,南方医科大学基础医学院人体解剖学国家重点学科,广东省广州市 510515
  • 作者简介:娜飞沙·斯马义,女,1995年生,新疆维吾尔自治区阿克苏市人,维吾尔族,南方医科大学在读硕士,主要从事血液方面研究。

Biological oxygen-carrying therapeutic agents: roles and applications

NafeishaŸSimayi, Chen Lizhi, Wang Xiangmeng, Huang Wenhua   

  1. Department of Human Anatomy, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, Guangdong Province, China
  • Received:2019-08-30 Revised:2019-08-31 Accepted:2019-10-26 Online:2020-07-28 Published:2020-04-19
  • Contact: Huang Wenhua, Professor, Department of Human Anatomy, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, Guangdong Province, China
  • About author:NafeishaSimayi, Master candidate, Department of Human Anatomy, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, Guangdong Province, China

摘要:

文题释义:

生物携氧治疗剂:是指具有载氧气功能、维持血液渗透压和酸碱平衡及扩充血容量的人工制剂。目前主要有氟碳化合物和血红蛋白类氧载体两大类。与简单的扩容剂相比,生物携氧治疗剂除能维持血液渗透压、酸碱平衡和血容量外,还具有较好的携氧能力,能向局部缺氧组织输氧。是临床上一种具有广阔的应用前景的携氧制剂。

血红蛋白类氧载体(Hemoglobin-based oxgen carriers,HBOCs):是一类通过血红蛋白分子表面化学修饰或分子间交联而形成分子量较大的血红蛋白制品,原料血红蛋白主要来源于人或动物血,目前应用较为广泛的是戊二醛聚合猪血红蛋白(pPolyCHb)和戊二醛聚合牛血红蛋(HBOC-201)。

背景:健康人献血虽然一定程度地缓解了临床用血的燃眉之急,但是单纯依靠健康人献血已不能从根本上解决血源短缺和血液安全性的问题。

目的:结合生物携氧治疗剂开发的意义,对生物携氧治疗剂所独有的特点进行阐述,总结近年来对生物携氧治疗剂的研究现状及应用进展,为进一步研究生物携氧治疗剂的作用及临床应用提供一定的理论基础。

方法:作者检索CNKI、万方、Pub Med等数据库中自2015年1月至2019年8月的相关文章,英文检索词为“blood substitute, hemoglobin oxygen carrier, artificial blood,oxygen-carrying therapeutic agent”,中文检索词为“血液代用品,血红蛋白类氧载体,人工血液,携氧治疗剂”,检索文献类型为研究原著、综述。初检文章418篇,再经过严格筛选后,对符合要求的46篇文献进行分类综述。

结果与结论:生物携氧治疗剂的临床效果较好,可维持血液渗透压、酸碱平衡和血容量,还具有较好的携氧能力,能向局部缺氧组织输氧并维持较长时间。它还具有易于贮存、便于运输等特点。生物携氧治疗剂在外科手术中得到广泛的应用,对扩充血容量、加快术后恢复有很大帮助,故其研发对于外科创伤及复苏、失血性休克、恶性贫血、心肌梗死等疾病均具有重要意义,并体现出良好的临床应用前景。

ORCID: 0000-0002-0365-4638(黄文华)

中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程

关键词:

生物携氧治疗剂, 血液代用品, 输血, 血红蛋白, 缺氧, 组织氧分压

Abstract:

BACKGROUND: Although blood donation by healthy people can relieve the urgent need of clinical blood to some extent, it is impossible to fundamentally solve the problem of blood shortage and blood safety by relying solely on blood donation by healthy people.

OBJECTIVE: In combination with the significance of the development of biological oxygen-carrying therapeutics, to expound the unique characteristics of biological oxygen-carrying therapeutics, and to summarize the research status and application progress of biological oxygen-carrying therapeutics in recent years, in order to provide a certain theoretical basis for further research on the role and clinical application of biological oxygen carrying therapeutic agents.

METHODS: The authors searched the relevant articles published from January 2015 to August 2019 in the databases of CNKI, Wanfang and PubMed. The keywords were “blood substitute, hemoglobin oxygen carrier, artificial blood, oxygen-carrying therapeutic agent” in English and Chinese. Types of search literature included original research and reviews. Initially 418 articles were included, and finally 46 eligible articles were classified and reviewed.

RESULTS AND CONCLUSION: The biological oxygen-carrying therapeutic agent has a good clinical effect. It can maintain blood osmotic pressure, acid-base balance and blood volume, and also has good oxygen-carrying capacity. It can deliver oxygen to local hypoxic tissue for a long time. It is also easy to store and transport. Biological oxygen-carrying therapeutic agents have been widely used in surgery, which are of great help to expand blood volume and accelerate postoperative recovery. Therefore, the development of biological oxygen-carrying therapeutic agents is of great significance for surgical trauma and resuscitation, hemorrhagic shock, malignant anemia, myocardial infarction and other diseases. It shows a good clinical application prospect.

Key words: biological oxygen-carrying therapeutic agent, blood substitute, blood transfusion, hemoglobin, hypoxia, tissue oxygen partial pressure

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