中国组织工程研究

中国组织工程研究 ›› 2014, Vol. 18 ›› Issue (30): 4895-4899.doi: 10.3969/j.issn.2095-4344.2014.30.022

• 生物材料综述 biomaterial review • 上一篇    下一篇

骨组织工程支架材料的研究现状与应用前景

马新芳，张静莹   

  1. 大连大学医学部，辽宁省大连市  116622
  • 修回日期:2014-06-10 出版日期:2014-07-16 发布日期:2014-08-08
  • 通讯作者: 张静莹，讲师，大连大学医学部，辽宁省大连市 116622
  • 作者简介:马新芳，女，1993年生，河南省项城市人，汉族，大连大学本科在读，主要从事骨组织工程研究。
  • 基金资助:

    中国博士后科学基金面上项目(2014M551097)；辽宁省教育厅基金(2013481)；辽宁省博士启动基金 (20141198)；大连市科技计划项目(2013E11SF057)

Development of bone tissue engineering scaffold materials

Ma Xin-fang, Zhang Jing-ying   

  1. Medical School of Dalian University, Dalian 116622, Liaoning Province, China
  • Revised:2014-06-10 Online:2014-07-16 Published:2014-08-08
  • Contact: Zhang Jing-ying, Lecturer, Medical School of Dalian University, Dalian 116622, Liaoning Province, China
  • About author:Ma Xin-fang, Medical School of Dalian University, Dalian 116622, Liaoning Province, China
  • Supported by:

    the China Postdoctoral Science Foundation, No. 2014M551097; the Fund of Liaoning Education Bureau, No. 2013481; the Doctoral Initial Fund of Liaoning Province, No. 20141198; the Science and Technology Plan of Dalian City, No. 2013E11SF057

PDF

1474

被引次数

35

摘要：

背景：目前组织工程骨修复骨缺损在临床应用中较为关键的问题是建立血管网，为新骨的形成提供氧气及营养物质，并为机体提供代谢途径。
目的：综述近年组织工程骨支架材料的特点，并着重介绍复合支架材料的研究现状。
方法：以“骨组织工程，血管化，支架材料，复合支架材料”为中文检索词，以“bone tissue engineering， vascularization，scaffold，composite scaffold”英文检索词，应用计算机在中国期刊全文数据库和PubMed数据库检索2001年1月至2014年1月的相关文章，将所有文章进行初步筛选后，对保留的文章进一步详细分析、归纳并总结。
结果与结论：按照组织工程骨支架材料的来源不同，可将其分为人工合成材料、天然衍生材料和复合支架材料，单一支架材料难以作为最理想的材料修复骨缺损，复合支架材料能在不同程度上弥补单一支架材料的缺陷，因此近年来组织工程支架材料的发展由单一材料发展为复合材料，并呈现人工合成材料与天然材料有机结合的趋势。但复合支架材料在临床应用中仍然有许多尚待解决的问题，主要有控制复合材料比例，使材料降解速率与组织细胞的生长速率相适应，保持复合材料的多孔隙和高机械强度。


中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程


全文链接：

关键词: 生物材料, 骨生物材料, 骨组织工程, 支架材料, 复合支架, 血管化

Abstract:

BACKGROUND: Bone tissue engineering is the most promising way to treat bone defects at present. The key problem is to construct vascular networks which can provide oxygen and nutrients for new bone, and thereby provide a way for the body metabolism.
OBJECTIVE: To review the characteristics of bone tissue engineering scaffold materials and to introduce the development of composite scaffold materials.
METHODS: With the key words of “bone tissue engineering, scaffold, vascularization, composite scaffold” in Chinese and in English, respectively, a computer-based search was performed for articles published in CNKI and PubMed databases from January 2001 to January 2014. After the initial screening, the reserved articles were further detailed, summarized and concluded.
RESULTS AND CONCLUSION: According to the different sources, the bone tissue engineering scaffold materials can be divided into artificial materials, natural derivatives and composite scaffold materials. Single scaffold is difficult to be the most ideal material for repair of bone defects, while composite scaffold can make up for the defects of the single scaffold to different degrees. Therefore, in recent years, the bone tissue engineering scaffolds have developed from single to composite scaffolds and there is the trend of organic combination of artificial materials and natural derivatives. However, composite scaffolds have many problems to be solved in the clinical application. The main aspect is to control the proportion of the composite scaffold so that the degradation of materials can be matched with growth of tissues and cells. The other one is to keep the porous and high mechanical strength of the composite scaffold.


中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程


全文链接：

Key words: tissue engineering, stents, review

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