中国组织工程研究 ›› 2023, Vol. 27 ›› Issue (21): 3398-3406.doi: 10.12307/2023.467
• 生物材料综述 biomaterial review • 上一篇 下一篇
董士武1,周岚曦1,邵 路1,喻正文1,2
收稿日期:
2022-06-16
接受日期:
2022-08-08
出版日期:
2023-07-28
发布日期:
2022-11-24
通讯作者:
喻正文,副教授,硕士生导师,遵义医科大学口腔医学院,贵州省遵义市 563099;贵州省普通高等学校口腔疾病研究特色重点实验室,贵州省遵义市 563099
作者简介:
董士武,男,1997年生,山东省泰安市人,汉族,遵义医科大学在读硕士,主要从事口腔材料与牙列缺损缺失修复研究。
基金资助:
Dong Shiwu1, Zhou Lanxi1, Shao Lu1, Yu Zhengwen1, 2
Received:
2022-06-16
Accepted:
2022-08-08
Online:
2023-07-28
Published:
2022-11-24
Contact:
Yu Zhengwen, Associate professor, Master’s supervisor, School of Stomatology, Zunyi Medical University, Zunyi 563099, Guizhou Province, China; Key Laboratory of Oral Disease Research of Department of Guizhou Education, Zunyi 563099, Guizhou Province, China
About author:
Dong Shiwu, Master candidate, School of Stomatology, Zunyi Medical University, Zunyi 563099, Guizhou Province, China
Supported by:
摘要:
文题释义:
镁合金生物材料:在纯镁中加入Al、Zn、Ca、Mn、RE等无细胞毒性的合金元素可改善镁合金材料的力学性能、生物相容性、组织相容性,同时能在受植区为细胞黏附和骨的成长提供环境和支持。中图分类号:
董士武, 周岚曦, 邵 路, 喻正文. 镁合金生物材料降解对内皮化细胞的影响[J]. 中国组织工程研究, 2023, 27(21): 3398-3406.
Dong Shiwu, Zhou Lanxi, Shao Lu, Yu Zhengwen. Effect of magnesium alloy biomaterial degradation on endothelialized cells[J]. Chinese Journal of Tissue Engineering Research, 2023, 27(21): 3398-3406.
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1.1 资料来源
1.1.1 检索人及检索时间 由第一作者在2022年3月进行检索。
1.1.2 检索文献时限 检索时限为2015-2022年。
1.1.3 检索数据库 PubMed、中国知网数据库、Web of Science和Elsevier等。
1.1.4 检索词 中文“主题”检索词为“金属生物材料,镁合金材料,血管支架,内皮化,动物实验,体外实验”,英文“Subject”检索词为“Metal biomaterials,Magnesium alloy materials,Vascular stent, Reendothelializations,Animal experiment,in vitro”。
1.1.5 检索文献类型 研究原著和综述。
1.1.6 检索策略 中、英文文献检索策略,见图1。
1.2 入组标准
1.2.1 纳入标准 ①有关镁合金材料实验研究的文献;②有关内皮细胞培养研究的文献;③优先选择近5年发表的,同一领域主题中心相近、论据可靠的文献。
1.2.2 排除标准 ①与研究目的无相关性的文章;②重复性研究文章;③论点论据不明确文章。
1.3 质量评估及数据提取 应用计算机检索,按照筛选标准,通过阅读文题、摘要进行初步筛选,排除与主题相关性差及重复陈旧的文献,最终纳入116篇文献,纳入的文献包括研究原著和综述。文献检索流程图,见图2。
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文题释义:
镁合金生物材料:在纯镁中加入Al、Zn、Ca、Mn、RE等无细胞毒性的合金元素可改善镁合金材料的力学性能、生物相容性、组织相容性,同时能在受植区为细胞黏附和骨的成长提供环境和支持。镁合金由于其优异的生物相容性和可降解能力成为21世纪备受青睐的新型生物组织工程材料。目前大量研究表明镁合金在植入体内后会促进新骨形成,影响术区炎症因子的表达,但其过快的降解速度和降解过程中出现的皮下气肿是目前存在的问题。通过研究成骨前期镁合金对新生血管的影响,更进一步了解镁合金植入后降解相关的影响因素。对比不同材料与镁合金对术区血管内皮化的差别,总结目前改善镁合金降解问题的不同方法,优化合金化过程中选用的合金元素和含量,在改善镁合金降解速率的基础上,避免细胞毒性,增强材料强度,为后续临床研究和应用提供参考。
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