中国组织工程研究 ›› 2014, Vol. 18 ›› Issue (21): 3293-3298.doi: 10.3969/j.issn.2095-4344.2014.21.003

• 组织工程骨及软骨材料 tissue-engineered bone and cartilage materials • 上一篇    下一篇

生物活性玻璃联合颈椎椎间融合器在颈椎前路椎间融合中的应用

李  宏,李淳德,邑晓东,刘  洪   

  1. 北京大学第一医院骨科,北京市  100034
  • 出版日期:2014-05-21 发布日期:2014-05-21
  • 通讯作者: 李淳德,主任医师,博士生导师,北京大学第一医院骨科,北京市 100034
  • 作者简介:李宏,男,1977年生,陕西省西安市人,汉族,2006年北京大学医学部毕业,博士,副主任医师,主要从事脊柱外科,骨质疏松研究。

Anterior cervical discectomy and fusion by cervical cage with bioactive glass

Li Hong, Li Chun-de, Yi Xiao-dong, Liu Hong   

  1. Department of Orthopedics, Peking University First Hospital, Beijing 100034, China
  • Online:2014-05-21 Published:2014-05-21
  • Contact: Li Chun-de, Chief physician, Doctoral supervisor, Department of Orthopedics, Peking University First Hospital, Beijing 100034, China
  • About author:Li Hong, M.D., Associate chief physician, Department of Orthopedics, Peking University First Hospital, Beijing 100034, China

摘要:

背景:已有文献报道生物活性玻璃在骨不连、骨折愈合过程中有较佳的临床疗效,但其在脊柱骨融合过程中的效果鲜有报道。
目的:观察生物活性玻璃联合颈椎椎间融合器在颈椎前路椎间融合中应用的安全性和有效性。
方法:回顾性分析68例颈椎前路单节段椎间融合患者资料,全部病例均采用聚醚醚酮材料椎间融合器,其中内填充自体松质骨植骨32例为对照组,采用生物活性玻璃填充36例为实验组。随访观察两组植骨融合、神经功能恢复、椎间隙高度和颈椎生理曲度及伤口并发症等情况。
结果与结论:两组患者的神经功能改善效果相当,均未出现伤口感染及延迟愈合等并发症。治疗3个月时,实验组与对照组骨性融合率分别为94%,97%,组间比较差异无显著性意义;治疗6个月时全部融合。两组随访3,6,12个月时椎间隙高度和颈椎曲度指数均获得良好维持,组间比较差异无显著性意义。提示生物活性玻璃联合颈椎椎间融合器在颈椎前路椎间融合中有良好的临床安全性和有效性。


中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程


全文链接:

关键词: 生物材料, 骨生物材料, 生物活性玻璃, 椎间融合器, 颈椎前路, 安全性, 有效性

Abstract:

BACKGROUND: Bioactive glass has been largely reported to have perfect clinical results in the bone nonunion and fracture healing, but its effect during spinal fusion progress is rarely reported.
OBJECTIVE: To explore the safety and effectiveness of anterior cervical discectomy and fusion by cervical cage with bioactive glass
METHODS: A total of 68 cases of cervical spondylosis myelopathy were treated with single level anterior cervical discectomy and fusion. Their clinical data were retrospectively analyzed. All the cases underwent polyetheretherketone cervical cage with autogenous bone (n=32, control group) or bioactive glass (n=32, experimental group). The bone fusion, neurological functional recovery, intervertebral height, change of cervical curve and wound complications in the two groups was recorded and analyzed.
RESULTS AND CONCLUSION: Neurological improvement had no difference between the two groups and there was no complication about wound, such as infection and delayed healing. The average rate of bone fusion was 97% in the control group while 94% in the experiment group 3 months after operation which had no significant differences. Six months after operation, all cases gained bone fusion. The intervertebral height and change of cervical curve both maintained well in the two groups within 3, 6, 12 months after operation which had no significant differences between the two groups. So, anterior cervical discectomy and fusion by cervical cage with bioactive glass is safe and effective.


中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程


全文链接:

Key words: glass, cervical vertebrae, spinal fusion

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