中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (26): 4898-4902.doi: 10.3969/j.issn.1673-8225.2012.26.029

• 骨与关节综述 bone and joint review • 上一篇    下一篇

骨科关节置换、植入物置入等较大创伤型手术后静脉血栓前状态的 基因预测诊断

王 强，赵学凌   

  1. 昆明医学院第一附属医院骨科，云南省昆明市 650032
  • 收稿日期:2011-10-29 修回日期:2011-11-06 出版日期:2012-06-24 发布日期:2013-11-02
  • 通讯作者: 赵学凌，博士生导师，教授，主任医师，昆明医学院第一附属医院骨科，云南省昆明市650032 zhaoxuelin@vipkm169net
  • 作者简介:王强★，男，1972年生，河北省张家口市人，汉族，昆明医学院在读硕士，主要从事脊柱外科与深静脉血栓方面的研究。 1289229840@qq.com

Prethrombotic state gene predictions and diagnosis of venous thromboembolism after large traumatic surgery including orthopedic joint replacement and implant placement

Wang Qiang, Zhao Xue-ling   

  1. Department of Orthopedics, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
  • Received:2011-10-29 Revised:2011-11-06 Online:2012-06-24 Published:2013-11-02
  • Contact: Zhao Xue-ling, Doctoral supervisor, Professor, Chief physician, Department of Orthopedics, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China zhaoxuelin@vipkm169net
  • About author:Wang Qiang★, Studying for master’s degree, Department of Orthopedics, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China 1289229840@qq.com

PDF

536

被引次数

17

摘要：

背景：目前创伤或骨科手术后的静脉血栓栓塞症早期基因诊断日益受到重视。
目的：综述目前用于预测诊断骨科术后静脉血栓栓塞症较为成熟的一些基因的研究进展。
方法：通过网络检索CNKI和PubMed数据库等2000-01/2011-01关于骨科术后静脉血栓基因诊断的文章，在标题和摘要中以“静脉血栓形成，深静脉血栓，肺栓塞，基因，诊断”或“thrombosis；DVT；PE；gene”为关键词。
结果与结论：近年来临床和基础研究证实，骨科术后的静脉血栓栓塞症是人类典型的多基因遗传性疾病，至今发现了一些和血液高凝有关的突变基因与静脉血栓形成有密切关系，分别是：凝血因子V，抗凝血酶Ⅲ，蛋白C，蛋白S，纤溶酶原，纤维蛋白原，肝素辅因子Ⅱ，血栓调节蛋白和凝血因子Ⅻ。了解骨科术后静脉血栓栓塞症的遗传性致病基因机制，有利于早诊断、早治疗，降低其危害。

关键词: 深静脉血栓, 骨科术后, 静脉血栓形成, 肺栓塞, 基因, 诊断, 人工关节, 植入体

Abstract:

BACKGROUND: At present, we pay more attention on the early genetic diagnosis of venous thromboembolism after traumatic or orthopedic surgery.
OBJECTIVE: To summarize the mature gene research used to diagnosis the venous thromboembolism after orthopedic surgery.
METHODS: CNKI database and PubMed database (2000-01/2011-01) were searched through Web with the key words of “venous thrombosis, deep venous thrombosis, pulmonary embolism, genes, diagnosis” or “thrombosis, DVT, PE, gene”.
RESULTS AND CONCLUSION: Recent clinical and basic research showed that venous thromboembolism was a typical polygenic hereditary disease. And we also found some mutant gene related to high blood coagulation was closely related with venous thrombosis. These mutant gene included prothrombinase V, antithrombin Ⅲ, protein C, protein S, plasminogen, fibrinogen, heparin cofactor Ⅱ, thrombomodulin and prothrombinase Ⅻ. Understanding of the hereditary pathogenic gene mechanism for venous thromboembolism was in favor of early diagnosis and treatment and reduced the harm.

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