中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (14): 2637-2640.doi: 10.3969/j.issn.1673-8225.2012.14.034

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

脑肿瘤干细胞的研究现状★

王欣欣1，刘季平2   

  1. 1内蒙古科技大学包头医学院病理教研室，内蒙古自治区包头市  014010；2内蒙古北方重工集团职工医院神经外科，内蒙古自治区包头市  014030
  • 收稿日期:2011-07-25 修回日期:2011-09-06 出版日期:2012-04-01 发布日期:2012-04-01
  • 通讯作者: 刘季平，副主任医师，内蒙古北方重工集团职工医院神经外科，内蒙古自治区包头市 014030
  • 作者简介:王欣欣★，女，1982年生，内蒙古自治区通辽市人，蒙古族，2007年辽宁医学院毕业，硕士，讲师，主要从事脑肿瘤的病理学研究。57667478@qq.com

Research progress in brain tumor stem cells

Wang Xin-xin1, Liu Ji-ping2   

  1. 1Department of Pathology, Baotou Medical College of Inner Mongolia University of Science and Technology, Baotou  014010, Inner Mongolia Autonomous Region, China; 2Department of Neurosurgery, Staff Hospital of Inner Mongolia North Heavy Industries Group Co., Ltd., Baotou  014030, Inner Mongolia Autonomous Region, China
  • Received:2011-07-25 Revised:2011-09-06 Online:2012-04-01 Published:2012-04-01
  • Contact: author: Liu Ji-ping, Associate chief physician, Department of Neurosurgery, Staff Hospital of Inner Mongolia North Heavy Industries Group Co., Ltd., Baotou 014030, Inner Mongolia Autonomous Region, China
  • About author:Wang Xin-xin★, Master, Lecturer, Department of Pathology, Baotou Medical College of Inner Mongolia University of Science and Technology, Baotou 014040, Inner Mongolia Autonomous Region, China 57667478@qq.com

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摘要：

背景：在脑肿瘤中存在一种具有自我更新、无限增殖与多向分化能力的细胞，即脑肿瘤干细胞。脑肿瘤干细胞被认为是脑肿瘤发生、发展、转移与复发的根源。
目的：总结和探讨脑肿瘤干细胞的研究现状。
方法：以“脑肿瘤、脑肿瘤干细胞”为检索词，应该计算机检索Pubmed 数据库1977-01/2011-07的相关文章，并查阅与干细胞及脑肿瘤干细胞实验有关的书籍，对资料进行初审，选取符合要求的有关文章共32 篇。
结果与结论：在恶性脑肿瘤中存在脑肿瘤干细胞。脑肿瘤干细胞是恶性脑肿瘤发生、发展、转移及复发的根源，其表达特异性的CD133、Nestin蛋白和ABC转运体。目前已经获得了分离脑肿瘤干细胞的简便方法。CD133阳性的肿瘤干细胞所占的比例与脑肿瘤的恶性程度呈正相关，可作为预后诊断指标之一。
 

关键词: 脑肿瘤, 脑肿瘤干细胞, CD133, Nestin蛋白, 综述文献

Abstract:

BACKGROUND: Research in recent years has discovered some stem cell-like cells exist in brain tumors, which have the properties of endless cell proliferation, uncontrolled self-renewal and multi-directional differentiation, and they are called as brain tumor stem cells. Brain tumor stem cells play a key role in the progress of tumorigenesis, growth, invasion, metastasis and recurrence.
OBJECTIVE: To conclude and explore the current studies on brain tumor stem cells.
METHODS: A computer-based search of Pubmed Database was performed to retrieve relevant articles about brain tumor and brain tumor stem cells published from January 1977 to July 2011. Books on stem cells and brain tumor stem cells were also retrieved. The data were selected primarily, and 32 articles related to brain tumor stem cells were selected.
RESULTS AND CONCLUSION: Brain tumor stem cells exist in malignant brain tumor, and they are the origin of the occurrence, development, metastasis and recurrence of malignant brain tumor. Brain tumor stem cells express CD133, Nestin protein and ABC transporter in malignant brain tumors. Recently, a simple method has been obtained to isolate brain tumor stem cells. The proportion of CD133 positive tumor stem cells is positively correlated with the severity of malignant brain tumors, which can be used as a diagnostic indicator of prognosis.

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