关键词: 黄芪注射液, 血必净注射液, 肾移植, 肺部感染, 人免疫球蛋白

Abstract:

BACKGROUND: Many experiments and clinical studies confirmed that astragalus and Xuebijing injections can strengthen body immunity and block inflammatory response in vivo, but there are no reporters on application of astragalus and Xuebijing injections for the infection after transplantation.
OBJECTIVE: To observe the joint application effect of astragalus and Xuebijing injections on pulmonary infection after renal transplantation.
METHODS: Totally 28 cases who suffered pulmonary infection within one year after renal transplantation and had no obvious improvement in clinical symptoms and imaging examination at 5 days after stop using immunosuppressant and received anti-infective treatment. These cases were divided randomly into two groups (14 for each), treatment group and control group, to receive immunization support therapy based on the conventional therapy. Conventional therapy included immunosuppressant adjustment, empirical anti-infection, selection of anti-infective agents according to drug sensitive result and other symptomatic treatments like sputum excretion, temperature reduction, and adjustment internal environment. For patients who suffered severe infection, ulinastatin and breathing machine were used to protect the functions of each organ and assist breathing. Immunization support included: astragalus injection and Xuebijing injection for the treatment group; human normal immunoglobulin for the control group by intravenous drip.
RESULTS AND CONCLUSION: Compared with the number of lymph cells of CD3⁺CD4⁺ and CD3⁺CD8⁺ from the patients with treatment group before taking immunization support drugs, the lymph cells thereof obviously increased after 7 days. There was no significant difference in the improvement rate, the period from the time of admission to the time of getting better after infection, the average length of stay, the mortality rate and the incidence of acute rejection between the treatment group and the control group (P > 0.05). Jointly applying the astragalus and Xuebijing injections on the basis of the positive conventional therapy can promote the increase of CD3⁺CD4⁺CD8⁺, restore the overly inhibitory immunologic function at different levels and shorten the disorganization time adjusted by immunologic function to sustain the balance of immune inflammation regulatory function, improve prognosis, obtain the similar therapeutic effect of human normal immunoglobulin, and at the same time, the toxic side effect is small.